Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Ankit A Desai"'
Autor:
Sergey Kurdyukov, Cody A Eccles, Ankit A Desai, Manuel Gonzalez-Garay, Jason X-J Yuan, Joe G N Garcia, Olga Rafikova, Ruslan Rafikov
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203493 (2018)
Pulmonary Arterial Hypertension (PAH) is a fatal disorder with limited treatment options and reduced life expectancy after diagnosis. Complex genetic backgrounds in PAH complicates identification of causative mutations that is essential for an unders
Externí odkaz:
https://doaj.org/article/f5cecf18802948468813981919888e37
Autor:
Ang Luo, Rongrong Hao, Xia Zhou, Yangfan Jia, Changlei Bao, Lei Yang, Lirong Zhou, Chenxin Gu, Ankit A. Desai, Haiyang Tang, Ai-ai Chu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remolding and occlusion, leading to the elevated pulmonary arterial pressures, right ventricular hypertrophy, and eventual heart failure if le
Externí odkaz:
https://doaj.org/article/0a243434c1294130bac52baee3687e36
Autor:
Olga Rafikova, Mary L Meadows, Jason M Kinchen, Robert P Mohney, Emin Maltepe, Ankit A Desai, Jason X-J Yuan, Joe G N Garcia, Jeffrey R Fineman, Ruslan Rafikov, Stephen M Black
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150480 (2016)
There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis of the metabolic changes in lungs at the early stage of PH, characterized by increased pulm
Externí odkaz:
https://doaj.org/article/55c5de473c2c4faaa18587933f9f342c
Autor:
Julio D Duarte, Ankit A Desai, Justin R Sysol, Taimur Abbasi, Amit R Patel, Roberto M Lang, Akash Gupta, Joe G N Garcia, Victor R Gordeuk, Roberto F Machado
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163013 (2016)
Diastolic dysfunction is common in sickle cell disease (SCD), and is associated with an increased risk of mortality. However, the molecular pathogenesis underlying this development is poorly understood. The aim of this study was to identify a gene ex
Externí odkaz:
https://doaj.org/article/4d8849aebbee4a859569a94654b875a0
Autor:
Julia H Indik, Vineet Nair, Ruslan Rafikov, Iwan S Nyotowidjojo, Jaskanwal Bisla, Mayank Kansal, Devang S Parikh, Melissa Robinson, Anand Desai, Megha Oberoi, Akash Gupta, Taimur Abbasi, Zain Khalpey, Amit R Patel, Roberto M Lang, Samuel C Dudley, Bum-Rak Choi, Joe G N Garcia, Roberto F Machado, Ankit A Desai
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164526 (2016)
Sudden death is a leading cause of mortality in sickle cell disease, implicating ventricular tachyarrhythmias. Prolonged QTc on an electrocardiogram (ECG), commonly seen with myocardial ischemia, is a known risk for polymorphic ventricular tachycardi
Externí odkaz:
https://doaj.org/article/9f2a02da94f940d194963dbc14c1f793
Autor:
Angie H. Fares, Ankit K. Desai, Laura E. Case, Cassie Sharon, Amy Klinepeter, Amelia Kirby, Matthew T. Lisi, Rebecca L. Koch, Priya S. Kishnani
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 41, Iss , Pp 101141- (2024)
Infantile-onset Pompe disease (IOPD) is caused by a deficiency in the enzyme acid alpha-glucosidase (GAA). It is characterized by severe and progressive hypertrophic cardiomyopathy and muscle weakness with death in the first 2 years of life if left u
Externí odkaz:
https://doaj.org/article/6ea6d9796f1448e0a4eef059199db424
Autor:
Adam Bress, Jin Han, Shitalben R Patel, Ankit A Desai, Ibrahim Mansour, Vicki Groo, Kristin Progar, Ebony Shah, Thomas D Stamos, Coady Wing, Joe G N Garcia, Rick Kittles, Larisa H Cavallari
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e71268 (2013)
The objective of this study was to examine the extent to which aldosterone synthase genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum aldosterone in African Americans with heart failure. Clinical data, echocard
Externí odkaz:
https://doaj.org/article/e417c8d65c39463190e3d4e5b3409f65
Autor:
Hui-An Chen, Rai-Hseng Hsu, Ching-Ya Fang, Ankit K. Desai, Ni-Chung Lee, Wuh-Liang Hwu, Fuu-Jen Tsai, Priya S. Kishnani, Yin-Hsiu Chien
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPompe disease, a lysosomal storage disorder, is characterized by acid α-glucosidase (GAA) deficiency and categorized into two main subtypes: infantile-onset Pompe disease (IOPD) and late-onset Pompe disease (LOPD). The primary treatment,
Externí odkaz:
https://doaj.org/article/d580f3c7d33d45768fcfbe1d68b78034
Autor:
Ankit K. Desai, Garima Shrivastava, Christina L. Grant, Raymond Y. Wang, Trevor D. Burt, Priya S. Kishnani
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHigh sustained anti-rhGAA antibody titers (HSAT; ≥12,800) are directly linked to reduced efficacy of enzyme replacement therapy (ERT) and subsequent clinical deterioration in infantile-onset Pompe disease (IOPD). We have previously demo
Externí odkaz:
https://doaj.org/article/feaa2ff9617e4639b0282d4875ed2de3
Autor:
Ankit K. Desai, P. Brian Smith, John S. Yi, Amy S. Rosenberg, Trevor D. Burt, Priya S. Kishnani
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe efficacy of enzyme replacement therapy (ERT) with alglucosidase alfa for infantile-onset Pompe disease (IOPD) is limited in some patients due to the development of high and sustained antibody titers (HSAT; ≥12,800).MethodsWe carried
Externí odkaz:
https://doaj.org/article/ec2469dc10d54eddb7249c22c74a9079