Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Ankit A, Desai"'
Autor:
Angie H. Fares, Ankit K. Desai, Laura E. Case, Cassie Sharon, Amy Klinepeter, Amelia Kirby, Matthew T. Lisi, Rebecca L. Koch, Priya S. Kishnani
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 41, Iss , Pp 101141- (2024)
Infantile-onset Pompe disease (IOPD) is caused by a deficiency in the enzyme acid alpha-glucosidase (GAA). It is characterized by severe and progressive hypertrophic cardiomyopathy and muscle weakness with death in the first 2 years of life if left u
Externí odkaz:
https://doaj.org/article/6ea6d9796f1448e0a4eef059199db424
Autor:
Ang Luo, Rongrong Hao, Xia Zhou, Yangfan Jia, Changlei Bao, Lei Yang, Lirong Zhou, Chenxin Gu, Ankit A. Desai, Haiyang Tang, Ai-ai Chu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remolding and occlusion, leading to the elevated pulmonary arterial pressures, right ventricular hypertrophy, and eventual heart failure if le
Externí odkaz:
https://doaj.org/article/0a243434c1294130bac52baee3687e36
Autor:
Hui-An Chen, Rai-Hseng Hsu, Ching-Ya Fang, Ankit K. Desai, Ni-Chung Lee, Wuh-Liang Hwu, Fuu-Jen Tsai, Priya S. Kishnani, Yin-Hsiu Chien
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPompe disease, a lysosomal storage disorder, is characterized by acid α-glucosidase (GAA) deficiency and categorized into two main subtypes: infantile-onset Pompe disease (IOPD) and late-onset Pompe disease (LOPD). The primary treatment,
Externí odkaz:
https://doaj.org/article/d580f3c7d33d45768fcfbe1d68b78034
Autor:
Ankit K. Desai, Garima Shrivastava, Christina L. Grant, Raymond Y. Wang, Trevor D. Burt, Priya S. Kishnani
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHigh sustained anti-rhGAA antibody titers (HSAT; ≥12,800) are directly linked to reduced efficacy of enzyme replacement therapy (ERT) and subsequent clinical deterioration in infantile-onset Pompe disease (IOPD). We have previously demo
Externí odkaz:
https://doaj.org/article/feaa2ff9617e4639b0282d4875ed2de3
Autor:
Ankit K. Desai, P. Brian Smith, John S. Yi, Amy S. Rosenberg, Trevor D. Burt, Priya S. Kishnani
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe efficacy of enzyme replacement therapy (ERT) with alglucosidase alfa for infantile-onset Pompe disease (IOPD) is limited in some patients due to the development of high and sustained antibody titers (HSAT; ≥12,800).MethodsWe carried
Externí odkaz:
https://doaj.org/article/ec2469dc10d54eddb7249c22c74a9079
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Pulmonary arterial hypertension (PAH) is a rare, complex, and deadly cardiopulmonary disease. It is characterized by changes in endothelial cell function and smooth muscle cell proliferation in the pulmonary arteries, causing persistent vaso
Externí odkaz:
https://doaj.org/article/b7a483237cff48d19a4e3a0e9c6fdd9b
Autor:
Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu, Yanan Sun, Weitao Cao, Ting Wang, Tae-Hwi Schwantes-An, John S. Choy, Samisubbu Naidu, Ang Luo, Wenguang Yin, Stephen M. Black, Jian Wang, Pixin Ran, Ankit A. Desai, Haiyang Tang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 s
Externí odkaz:
https://doaj.org/article/d445e26603ba40349d02e11cee010aa0
Autor:
Dipika K Mitra, Rutuja Jeevandas Donde, Ankit B Desai, Kashmira Prakash Ghangrekar, Priyanka Nandakumar Potdar, Gaurav Prabhakar Shetty
Publikováno v:
Journal of Indian Society of Periodontology, Vol 27, Iss 1, Pp 70-75 (2023)
Background: Periodontal disease is ubiquitous and its treatment requires a detailed treatment plan. Biomaterials are often used along with demineralized freeze-dried bone allograft (DFDBA) for periodontal regeneration. One percent metformin has evolv
Externí odkaz:
https://doaj.org/article/1074bf53241a4031a68677459c5fd7ab
Autor:
Katherine H. Kim, Ankit K. Desai, Erika R. Vucko, Tracy Boggs, Priya S. Kishnani, Barbara K. Burton
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 36, Iss , Pp 100981- (2023)
A late-onset Pompe disease patient developed high sustained antibody titers (HSAT) of ≥51,200 after 11+ years on alglucosidase alfa and previous tolerance. There was a corresponding worsening of motor function and rise in urinary glucose tetrasacch
Externí odkaz:
https://doaj.org/article/a4e5cd8daf564e5ba10738d304447e3f
Autor:
Clare C. Prohaska, Xu Zhang, Tae‐Hwi L. Schwantes‐An, Robert S. Stearman, Stanley Hooker, Rick A. Kittles, Micheala A. Aldred, Katie A. Lutz, Michael W. Pauciulo, William C. Nichols, Ankit A. Desai, Victor R. Gordeuk, Roberto F. Machado
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 2, Pp n/a-n/a (2023)
Abstract Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and endothelial barrier function. In this study, we explore the association of RASA3 genetic va
Externí odkaz:
https://doaj.org/article/d44c31783d1a4d9e9cfa57839108515e