Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Autor: Aimo, A, Vergaro, G, Gonzalez, A, Barison, A, Lupon, J, Delgado, V, Richards, AM, de Boer, RA, Thum, T, Arfsten, H, Hulsmann, M, Falcao-Pires, I, Diez, J, Foo, RSY, Chan, MYY, Anene-Nzelu, CG, Abdelhamid, M, Adamopoulos, S, Anker, SD, Belenkov, Y, Gal, TB, Cohen-Solal, A, Bohm, M, Chioncel, O, Jankowska, EA, Gustafsson, F, Hill, L, Jaarsma, T, Januzzi, JL, Jhund, P, Lopatin, Y, Lund, LH, Metra, M, Milicic, D, Moura, B, Mueller, C, Mullens, W, Nunez, J, Piepoli, MF, Rakisheva, A, Ristic, AD, Rossignol, P, Savarese, G, Tocchetti, CG, van Linthout, S, Volterrani, M, Seferovic, P, Rosano, G, Coats, AJS, Emdin, M, Bayes-Genis, A

Publikováno v: European Journal of Heart Failure
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::08f694b65ad5047fcfb7f00f7343ac22
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7241

Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology

Autor: Bayes-Genis, A, Aimo, A, Jhund, P, Richards, M, De Boer, RA, Arfsten, H, Fabiani, I, Lupon, J, Anker, SD, Gonzalez, A, Castiglione, V, Metra, M, Mueller, C, Nunez, J, Rossignol, P, Barison, A, Butler, J, Teerlink, J, Filippatos, G, Ponikowski, P, Vergaro, G, Zannad, F, Seferovic, P, Rosano, G, Coats, AJS, Emdin, M, Januzzi, JL

Publikováno v: European Journal of Heart Failure
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

The approval of new heart failure (HF) therapies has slowed over the past two decades in part due to the high costs of conducting large randomized clinical trials that are needed to adequately power major clinical endpoint studies. Several biomarkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::efdea212d6dcc90f0ece90a1018e211f
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7303

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, 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Publikováno v: Paediatrics Publications
New England journal of medicine, 377(12), 1119-1131. Massachussetts Medical Society

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9352d7ff99dee51001e96d9b05970fb
https://doi.org/10.1056/nejmoa1707914

Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry

Autor: Kapelios, CJ, Laroche, C, Crespo-Leiro, MG, Anker, SD, Coats, AJS, Díaz-Molina, B, Filippatos, G, Lainscak, M, Maggioni, AP, McDonagh, T, Mebazaa, A, Metra, M, Moura, B, Mullens, W, Piepoli, MF, Rosano, GMC, Ruschitzka, F, Seferovic, PM, Lund, LH, Heart Failure Long-Term Registry Investigators Group

AIMS: Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ac913b99e483c4c6247de6a858852343
https://openaccess.sgul.ac.uk/id/eprint/111908/1/CrespoLeiro_Maria_2020_Association_between_loop_diuretic_dose_changes.pdf

Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure

Autor: Kotecha, D, Gill, SK, Flather, MD, Holmes, J, Packer, M, Rosano, G, Böhm, M, McMurray, JJV, Wikstrand, J, Anker, SD, van Veldhuisen, DJ, Manzano, L, von Lueder, TG, Rigby, AS, Andersson, B, Kjekshus, J, Wedel, H, Ruschitzka, F, Cleland, JGF, Damman, K, Redon, J, Coats, AJS, Beta-Blockers in Heart Failure Collaborative Group

BACKGROUND: Moderate and moderately severe renal impairment are common in patients with heart failure and reduced ejection fraction, but whether beta-blockers are effective is unclear, leading to underuse of life-saving therapy. OBJECTIVES: This stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::27c2e978494a6f6fb69c1ac3de3ee792
https://openaccess.sgul.ac.uk/id/eprint/111561/1/1-s2.0-S073510971937932X-main.pdf