Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anke Spoo"'
Publikováno v:
British Journal of Haematology. 122:579-589
Summary. Marrow stromal cells play an important role in regulating the development and proliferation of haematopoietic stem cells (HSC) within the marrow microenvironment. However, the molecular mechanisms of stem cell–stromal cell interactions are
Autor:
Laurent Brault, Rebekka Grundler, Vanda Pogacic, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Antonello Villa, Christine Dierks, Stefan Knapp, Tobias Dechow, Sabine Woetzel, Anke Spoo, Andrea Biondi, Alex N. Bullock, Sabine Ehret
Publikováno v:
The Journal of Experimental Medicine
FLT3-ITD–mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD–mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d43b6e0eb2aef17a5b7dc88a50d2fa
http://hdl.handle.net/10281/18542
http://hdl.handle.net/10281/18542
Autor:
Rebekka Grundler, Anke Spoo, Alec Bullock, Laurent Brault, Sabine Woetzel, Sabine Ehret, Tobias Dechow, Stefan Knapp, Martjin Nawijn, Andrea Biondi, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Christine Dierks
Publikováno v:
BLOOD. 112(11)
Previous work has shown that FLT3-ITD mediated leukemogenesis is associated with increased expression of PIM1 and PIM2 serine/threonine kinases. Here we show that retroviral expression of FLT3-ITD could not compensate impaired clonogenic in vitro gro
Publikováno v:
Blood. 109(2)
CXCR4 chemokine receptors retain hematopoietic progenitors and leukemia cells within the marrow microenvironment. We prospectively evaluated the prognostic implication of CXCR4 in 90 consecutive patients with acute myelogenous leukemia (AML) by flow
Publikováno v:
British journal of haematology. 122(4)
Marrow stromal cells play an important role in regulating the development and proliferation of haematopoietic stem cells (HSC) within the marrow microenvironment. However, the molecular mechanisms of stem cell-stromal cell interactions are not fully
Publikováno v:
Blood. 104:1072-1072
Despite major improvements in the understanding and treatment of certain leukemias during the past years, the overall survival of patients with acute myelogenous leukemia (AML) remains poor and new prognostic markers and therapeutic strategies are ur