Výsledky vyhledávání - "Anke Sönmez"

Akademický článek

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags

Autor: Andreas Müller, Martin Neukam, Anna Ivanova, Anke Sönmez, Carla Münster, Susanne Kretschmar, Yannis Kalaidzidis, Thomas Kurth, Jean-Marc Verbavatz, Michele Solimena

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Correlative light and electron microscopy (CLEM) is a powerful approach to investigate the molecular ultrastructure of labeled cell compartments. However, quantitative CLEM studies are rare, mainly due to small sample sizes and the sensitivi

Externí odkaz: https://doaj.org/article/069d03a33d2f4c818999027d415bc62e

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Autor: Hassan Mziaut, Bernard Mulligan, Peter Hoboth, Oliver Otto, Anna Ivanova, Maik Herbig, Desiree Schumann, Tobias Hildebrandt, Jaber Dehghany, Anke Sönmez, Carla Münster, Michael Meyer-Hermann, Jochen Guck, Yannis Kalaidzidis, Michele Solimena

Publikováno v: Molecular Metabolism, Vol 5, Iss 8, Pp 656-668 (2016)

Objective: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting

Externí odkaz: https://doaj.org/article/28fbe7227080437ba09617f7004a40d9

Zobrazit plný text záznamu

Insulin mRNA is stored in RNA granules in resting beta cells

Autor: K. Ganß, E. Quezada, Anke Sönmez, Matthias Selbach, Carla Münster, Michele Solimena, C. Wegbrod, Nicole Kipke, Marius Distler, J. Vasiljević, Eyke Schöniger, Djordje Vasiljevic, D. Friedland

The glucose-stimulated biosynthesis of insulin in pancreatic islet beta cells is post-transcriptionally regulated. Several RNA-binding proteins (RBPs) that regulate Insulin mRNA stability and translation also bind mRNAs coding for other insulin secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d96a12029bbbe4e38dcbb63d3fb241
https://doi.org/10.1101/2021.05.07.443159

Zobrazit plný text záznamu

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Autor: Michele Solimena, Anke Sönmez, Andreas Müller, Mario R. Ermácora, Pamela L. Toledo, C. Wegbrod, Juha M. Torkko

Publikováno v: bioRxiv

Type 1 diabetes islet cell autoantigen 512 (ICA512) is a tyrosine phosphatase-like intrinsic membrane protein involved in the biogenesis and turnover of insulin secretory granules (SGs) in pancreatic islet β-cells. Whereas its membrane proximal and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724e30c8e3d6130e0b5a1ea49724db7b

Zobrazit plný text záznamu

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Autor: Peter Hoboth, Oliver Otto, B. P. Mulligan, Michele Solimena, Tobias Hildebrandt, Desiree M. Schumann, Anke Sönmez, Maik Herbig, Michael Meyer-Hermann, Jaber Dehghany, Hassan Mziaut, Carla Münster, Anna Ivanova, Yannis Kalaidzidis, Jochen Guck

Publikováno v: Molecular Metabolism, Vol 5, Iss 8, Pp 656-668 (2016)
Mol. Metab. 5, 656-68 (2016)
Molecular Metabolism

Objective Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51388b3180a4086174a0ea77eb14031f
http://www.sciencedirect.com/science/article/pii/S2212877816300527

Zobrazit plný text záznamu

PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells

Autor: A. Friedrich, Michele Solimena, Suchita Nath-Sain, Anke Sönmez, Klaus-Peter Knoch, C. Wegbrod, Antje Petzold, Mike Beck, Carla Münster, Merja Roivainen, Hendryk Schneider

Publikováno v: Molecular Metabolism

Glucose and GLP-1 stimulate not only insulin secretion, but also the post-transcriptional induction of insulin granule biogenesis. This process involves the nucleocytoplasmic translocation of the RNA binding protein PTBP1. Binding of PTBP1 to the 3�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec003aaba9a2bcfcf903f6e25c89cd5

Zobrazit plný text záznamu

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies

Autor: Martina Lachnit, Andreas Müller, Hassan Mziaut, Michael Meyer-Hermann, Jaber Dehghany, Yannis Kalaidzidis, Peter Hoboth, Anna Ivanova, Michele Solimena, Anke Sönmez

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 112, E667-E676 (2015)

Insulin secretion is key for glucose homeostasis. Insulin secretory granules (SGs) exist in different functional pools, with young SGs being more mobile and preferentially secreted. However, the principles governing the mobility of age-distinct SGs r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3fe18e5baaa414647b9233d3fc4f24
https://pubmed.ncbi.nlm.nih.gov/25827228

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání