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Autor:
Julia Kirchheiner, Ulrich M. Zanger, Jawahar Lal, Anke Rattay, G Zadoyan, Alexander Jetter, Eugen Muschler, Uwe Fuhr
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 105:374-379
The cytochrome P450 enzyme CYP2C8 appears to have a major role in pioglitazone metabolism. The present study was conducted to further clarify the role of individual CYPs and of the CYP2C8/9 polymorphisms in the primary metabolism of pioglitazone in v