Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Anke Penno"'
Autor:
Irina Alecu, Andrea Tedeschi, Natascha Behler, Klaus Wunderling, Christian Lamberz, MarioA.R. Lauterbach, Anne Gaebler, Daniela Ernst, Paul P. Van Veldhoven, Ashraf Al-Amoudi, Eicke Latz, Alaa Othman, Lars Kuerschner, Thorsten Hornemann, Frank Bradke, Christoph Thiele, Anke Penno
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 42-59 (2017)
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, su
Externí odkaz:
https://doaj.org/article/e23646b731034a248bd71501da457f6c
Autor:
Irina Alecu, Alaa Othman, Anke Penno, Essa M. Saied, Christoph Arenz, Arnold von Eckardstein, Thorsten Hornemann
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 60-71 (2017)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-
Externí odkaz:
https://doaj.org/article/c7c5df5b44594f978518016b29b78f0e
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1934-1947 (2016)
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluores
Externí odkaz:
https://doaj.org/article/cdbd3acd4b59425d8dbd60f6bbc0473f
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1237-1244 (2009)
Serine palmitoyltransferase (SPT) catalyzes the condensation of l-serine and palmitoyl-CoA, which is the rate-limiting step in the de novo synthesis of sphingolipids. SPT activity is commonly measured by monitoring the incorporation of radiolabeled l
Externí odkaz:
https://doaj.org/article/9f2f08634b1f48009d4c364f9dc219d5
Publikováno v:
J Cereb Blood Flow Metab
In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme β-hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers neurodegeneration. Although the pathology centers on neurons, β-hexosaminidase is mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a1267bd502b500e5238372a1668da2
https://doi.org/10.1177/0271678x19865917
https://doi.org/10.1177/0271678x19865917
Autor:
Eicke Latz, Victor Saavedra, Matthew Mangan, Anke Penno, Mario A. Lauterbach, Lars Kuerschner, Christoph Thiele
Publikováno v:
Autophagy
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7633b2425588b3dc8eb6ca3aa34a32
https://pubmed.ncbi.nlm.nih.gov/32835606
https://pubmed.ncbi.nlm.nih.gov/32835606
Autor:
Ashraf Al-Amoudi, Christoph Thiele, Frank Bradke, Anne Gaebler, Christian Lamberz, Andrea Tedeschi, Thorsten Hornemann, Irina Alecu, Klaus Wunderling, Mario A. Lauterbach, Alaa Othman, Paul P. Van Veldhoven, Anke Penno, Lars Kuerschner, Eicke Latz, Natascha Behler, Daniela Ernst
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 42-59 (2017)
Journal of lipid research 58(1), 42-59 (2016). doi:10.1194/jlr.M068676
Journal of lipid research 58(1), 42-59 (2016). doi:10.1194/jlr.M068676
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1f4d8a40b8aec71587cce2db32ed84
https://doi.org/10.1194/jlr.m068676
https://doi.org/10.1194/jlr.m068676
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1934-1947 (2016)
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c986c41912eca435bde67d4bbbc1f1d
http://www.sciencedirect.com/science/article/pii/S0022227520354018
http://www.sciencedirect.com/science/article/pii/S0022227520354018
Autor:
Anthony H. Futerman, Britta Brügger, Heinz G. Körschen, Katharina Gutbrod, Dagmar Wachten, Per Haberkant, Peter Dörmann, Mathias J. Gerl, Ayelet Vardi, Anke Penno, Andreas Rennhack, Bernadette Breiden, Konrad Sandhoff, Sophie Schonauer, Christoph Thiele, Hila Zigdon, Diana N. Raju
Publikováno v:
Journal of Biological Chemistry
The lysosomal acid beta-glucosidase GBA1 and the non-lysosomal beta-glucosidase GBA2 degrade glucosylceramide (GlcCer) to glucose and ceramide in different cellular compartments. Loss of GBA2 activity and the resulting accumulation of GlcCer results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f51c27f3b9e28ee3ef6547eea52c22
https://hdl.handle.net/11858/00-001M-0000-002C-AD61-C21.11116/0000-0004-6A27-A
https://hdl.handle.net/11858/00-001M-0000-002C-AD61-C21.11116/0000-0004-6A27-A
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1831:589-594
Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to other cellular organelles, lipid droplets are structurally unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3c51751c629a771dc0805314ce685f
https://doi.org/10.1016/j.bbalip.2012.12.001
https://doi.org/10.1016/j.bbalip.2012.12.001