Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anke Nijhuis"'
Autor:
Yuewei Xu, Sarah Spear, Yurui Ma, Marc P. Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R. Shepherd, Iain McNeish, Hector C. Keun, Anke Nijhuis
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113307- (2023)
Summary: Ovarian high-grade serous carcinoma (HGSC) is the most common subtype of ovarian cancer with limited therapeutic options and a poor prognosis. In recent years, poly-ADP ribose polymerase (PARP) inhibitors have demonstrated significant clinic
Externí odkaz:
https://doaj.org/article/f92b72689e9e4fa5ac20d9abaf4deae7
Autor:
Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, Evon Poon, Clare Eckold, Gabriel N. Valbuena, Yuewei Xu, Yusong Liu, Barbara Martins da Costa, Michael Gruet, Chiharu Wickremesinghe, Adrian Benito, Holger Kramer, Alex Montoya, David Carling, Elizabeth J. Want, Yann Jamin, Louis Chesler, Hector C. Keun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The prognosis of high-risk neuroblastoma is poor despite the availability of multimodal treatment. Here the authors show that high-risk neuroblastoma is sensitive to indisulam, a selective degrader of the splicing factor RBM39 through the dual target
Externí odkaz:
https://doaj.org/article/c91ed6203d624310b8e94805ee7888bd
Autor:
Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver
Publikováno v:
Clinical Science. 136:1405-1423
Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease (CD), linked to increased morbidity and costs. The present study investigates the contribution of Wingless-Int-1 (Wnt) signalling to intestinal fibrogenesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1935c75aad09cc58520371966448219
https://doi.org/10.1042/cs20210889
https://doi.org/10.1042/cs20210889
Publikováno v:
British Journal of Pharmacology. 179:2795-2812
RNA-binding motif protein 39 (RBM39) is an RNA-binding protein involved in transcriptional co-regulation and alternative RNA splicing. Recent studies have revealed that RBM39 is the unexpected target of aryl sulphonamides, which act as molecular glue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc89fc8a5dfc6f0a701f43dc2b7ea74
https://doi.org/10.1111/bph.15331
https://doi.org/10.1111/bph.15331
Autor:
Emily M E Barnes, Alexandros P. Siskos, Adrian Benito, Hector C. Keun, Yitao Xu, Eric O. Aboagye, Anke Nijhuis, Lili Herendi
Publikováno v:
British Journal of Cancer
BackgroundAkt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition. However, cancer cells can utilise alternative nutrients to glucose for energy suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53da64c307ab2a8a3d6658695e8f01f
https://doi.org/10.1038/s41416-020-0777-y
https://doi.org/10.1038/s41416-020-0777-y
Autor:
Lili Herendi, Hector C. Keun, Adrian Benito, Yusong Liu, Holger Kramer, Barbara Martins da Costa, David Carling, Louis Chesler, Yann Jamin, Arti Sikka, Eirini Kouloura, Gabriel N. Valbuena, Orli Yogev, Clare Eckold, Evon Poon, Elizabeth J. Want, Alex Montoya, Anke Nijhuis
Neuroblastoma is the most common solid tumour in childhood and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be particularly sensitive to ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3430a7ff5212d8bf937972bd8160617b
https://doi.org/10.1101/2020.12.18.423403
https://doi.org/10.1101/2020.12.18.423403
Autor:
Anke Nijhuis, Viviana Bustos, Áine M. Nolan, Alexandra Parker, Harry Harvey, Richard Poulsom, Andrew Silver, Brian J. Harvey, Warren Thomas, Jean McBryan
Publikováno v:
Oncotarget
// Viviana Bustos 1 , Aine M. Nolan 1 , Anke Nijhuis 2 , Harry Harvey 1 , Alexandra Parker 2 , Richard Poulsom 2 , Jean McBryan 1 , Warren Thomas 1 , Andrew Silver 2 and Brian J. Harvey 1 1 Department of Molecular Medicine, Education and Research Cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b79dff6aadf6456681a57c21c49803
https://doi.org/10.18632/oncotarget.20653
https://doi.org/10.18632/oncotarget.20653
Autor:
Paolo Biancheri, Roger Feakins, Shameer Mehta, Rosemary Jeffery, Andrew Silver, Anke Nijhuis, James O. Lindsay, Antonio Di Sabatino, Amy Lewis
Publikováno v:
Journal of Cellular and Molecular Medicine
Intestinal mesenchymal cells deposit extracellular matrix in fibrotic Crohn's disease (CD). The contribution of epithelial to mesenchymal transition (EMT) to the mesenchymal cell pool in CD fibrosis remains obscure. The miR‐200 family regulates fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bae069c155197a8759b513ccae0b0f
https://ueaeprints.uea.ac.uk/id/eprint/68337/
https://ueaeprints.uea.ac.uk/id/eprint/68337/
Autor:
Alexandra Parker, Mohamed A. Thaha, Sarah McDonald, Roger Feakins, Nirosha Suraweera, Robert Lowe, Aisha Jalaly, Cleo L. Bishop, Amy Lewis, Hannah Thompson, Luke Gammon, Tomoyoshi Soga, David Propper, Anke Nijhuis, Jacob G. Bundy, Rosemary Jeffery, Andrew Silver, Julie Adam
Publikováno v:
Human Molecular Genetics
Solid tumours have oxygen gradients and areas of near and almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors and were altered consistently in six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bf241fb6e3f9c0d86cafeb4fa263bd
https://doi.org/10.1093/hmg/ddx059
https://doi.org/10.1093/hmg/ddx059
Autor:
Roger Feakins, Andrew Silver, Anke Nijhuis, James O. Lindsay, Amy Lewis, Cleo L. Bishop, G Berti
Publikováno v:
Journal of Crohn's and Colitis. 13:S103-S104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15533ab30efda88ca80a11ec2fc818a
https://doi.org/10.1093/ecco-jcc/jjy222.159
https://doi.org/10.1093/ecco-jcc/jjy222.159