Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anke Mueller-Fahrnow"'
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
Suzanne Ackloo, Albert A. Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Ulrich A. K. Betz, Jark Böttcher, Peter J. Brown, Menorca Chaturvedi, Alisa Crisp, Danette Daniels, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V. Hartung, Alexander Hillisch, Evert Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R. Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H. Todd, Claudia Tredup, Jennifer Venable, Timothy M. Willson, Cheryl H. Arrowsmith
Publikováno v:
RSC Medicinal Chemistry.
Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging ‘open’ principles to develop a pharmacological tool for every human protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3307d439e596fca276308b7255fe64f6
https://doi.org/10.1039/d2md00441k
https://doi.org/10.1039/d2md00441k
Autor:
Anke Mueller-Fahrnow, Cheryl H. Arrowsmith, Aled M. Edwards, Oliver Kraemer, Matthias Zwick, Adrian Carter
Publikováno v:
Drug Discovery Today. 24:2111-2115
Biomedical scientists tend to focus on only a small fraction of the proteins encoded by the human genome despite overwhelming genetic evidence that many understudied proteins are important for human disease. One of the best ways to interrogate the fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e42e8ef5a792015926757c5e2cd3169
https://doi.org/10.1016/j.drudis.2019.06.020
https://doi.org/10.1016/j.drudis.2019.06.020
Autor:
Raina Seupel, Michael Sundström, Paul Brennan, Anke Mueller-Fahrnow, Andrea Introini, Adrian Carter
Publikováno v:
Target Discovery and Validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdbe3e737b41cc610ac15c2b027ba593
https://doi.org/10.1002/9783527818242.ch1
https://doi.org/10.1002/9783527818242.ch1
Publikováno v:
Archiv der Pharmazie. 349:692-697
The pharmaceutical industry is faced with significant challenges in its efforts to discover new drugs that address unmet medical needs. Safety concerns and lack of efficacy are the two main technical reasons for attrition. Improved early research too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f668cbc4e01f70f1d7feb5da33a08881
https://doi.org/10.1002/ardp.201600078
https://doi.org/10.1002/ardp.201600078
Autor:
David H. Drewry, Steve Hitchcock, Volker Dötsch, Ingo Hartung, Brian D. Marsden, Hisanori Matsui, C. Bountra, Carrow I. Wells, Marcus Bauser, Stefan Knapp, Volkhart Mj Li, Amélia Yi Viana, Christian Fischer, Mathias John Paul, Adrian Carter, Spiros Liras, Julian Blagg, Mark Edward Bunnage, Suzanne Ackloo, Adriaan P. IJzerman, Susanne Müller, Stephen V. Frye, Saul H Rosenberg, Natalie S Schneider, Daniel K Treiber, Andreas Gollner, David R. Damerell, Cora Scholten, Bryan L. Roth, Cheryl H. Arrowsmith, Charles E. Grimshaw, Aled M. Edwards, Kumar Singh Saikatendu, Timothy M. Willson, Jeremy L Baryza, Thomas Hanke, Masayuki Takizawa, Peter Brown, Terry V Hughes, James P. Edwards, Daniel Rauh, Trevor Howe, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Chris Tse, Vineet Pande, Anton Simeonov, Paul R. Thompson, Dafydd R. Owen, J.M. Elkins, Jark Böttcher, William J. Zuercher, Stefan Laufer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d718f899c5ce6099584927eb7f1b37e
https://doi.org/10.7554/elife.34311.009
https://doi.org/10.7554/elife.34311.009
Autor:
Julian Blagg, David H. Drewry, Steve Hitchcock, Hisanori Matsui, Carrow I. Wells, Daniel Rauh, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Adriaan P. IJzerman, Kumar Singh Saikatendu, Stefan Laufer, Timothy M. Willson, Paul R. Thompson, Chris Tse, Saul H Rosenberg, C. Bountra, Marcus Bauser, Dafydd R. Owen, Brian D. Marsden, Terry V Hughes, Daniel K Treiber, James P. Edwards, Bryan L. Roth, Cheryl H. Arrowsmith, Suzanne Ackloo, J.M. Elkins, Adrian Carter, Spiros Liras, Stefan Knapp, Christian Fischer, Susanne Müller, Amélia Yi Viana, Mathias John Paul, William J. Zuercher, Masayuki Takizawa, Jeremy L Baryza, Thomas Hanke, Peter Brown, David R. Damerell, Cora Scholten, Stephen V. Frye, Anton Simeonov, Mark Edward Bunnage, Charles E. Grimshaw, Andreas Gollner, Aled M. Edwards, Natalie S Schneider, Trevor Howe, Volker Dötsch, Ingo Hartung, Jark Böttcher, Vineet Pande, Volkhart Mj Li
Publikováno v:
eLife, Vol 7 (2018)
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba91100a44a3d9b67ccf3f2841cb55bf
Publikováno v:
Archiv der Pharmazie. 349(9)
The pharmaceutical industry is faced with significant challenges in its efforts to discover new drugs that address unmet medical needs. Safety concerns and lack of efficacy are the two main technical reasons for attrition. Improved early research too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb0eadc3479842027025be83b2181977
https://pubmed.ncbi.nlm.nih.gov/27335205
https://pubmed.ncbi.nlm.nih.gov/27335205
Autor:
Cheryl H, Arrowsmith, James E, Audia, Christopher, Austin, Jonathan, Baell, Jonathan, Bennett, Julian, Blagg, Chas, Bountra, Paul E, Brennan, Peter J, Brown, Mark E, Bunnage, Carolyn, Buser-Doepner, Robert M, Campbell, Adrian J, Carter, Philip, Cohen, Robert A, Copeland, Ben, Cravatt, Jayme L, Dahlin, Dashyant, Dhanak, Aled M, Edwards, Mathias, Frederiksen, Stephen V, Frye, Nathanael, Gray, Charles E, Grimshaw, David, Hepworth, Trevor, Howe, Kilian V M, Huber, Jian, Jin, Stefan, Knapp, Joanne D, Kotz, Ryan G, Kruger, Derek, Lowe, Mary M, Mader, Brian, Marsden, Anke, Mueller-Fahrnow, Susanne, Müller, Ronan C, O'Hagan, John P, Overington, Dafydd R, Owen, Saul H, Rosenberg, Bryan, Roth, Brian, Roth, Ruth, Ross, Matthieu, Schapira, Stuart L, Schreiber, Brian, Shoichet, Michael, Sundström, Giulio, Superti-Furga, Jack, Taunton, Leticia, Toledo-Sherman, Chris, Walpole, Michael A, Walters, Timothy M, Willson, Paul, Workman, Robert N, Young, William J, Zuercher
Publikováno v:
Nature chemical biology, vol 11, iss 8
Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef8fcb956cf99f46e7f3e8b49a6bfbf
https://pubmed.ncbi.nlm.nih.gov/26485080
https://pubmed.ncbi.nlm.nih.gov/26485080
Autor:
Clara D. Christ, Roman C. Hillig, Bernard Haendler, Hilmar Weinmann, Anke Mueller-Fahrnow, Naomi Barak, Markus Berger, Erik Eggert, Carlo Stresemann, Masoud Vedadi, Antonius Ter Laak, Stephan Siegel, Cora Scholten, Oleg Fedorov, Andrea Haegebarth, Amaury Ernesto Fernandez-Montalvan, Ursula Egner, Simon H. Holton, Peter Brown, Joerg Weiske, Mátyás Gorjánácz, Volker Badock, Ingo Hartung, Seong Joo Koo, Timo Stellfeld, Susanne Mueller, Kilian Huber, Cheryl H. Arrowsmith, Detlef Stoeckigt
Publikováno v:
Cancer Research. 77:5239-5239
Low reproducibility of published target validation studies as well as the frequent failure of genetic knock-down effects to phenocopy those of small molecule inhibitors have been recognized as road blocks for cancer drug discovery. Academic and indus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56594940be9cc1edaa3da3e7c254f327
https://doi.org/10.1158/1538-7445.am2017-5239
https://doi.org/10.1158/1538-7445.am2017-5239