Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anke M. Tukker"'
Autor:
Xiaoling Chen, Jean-Christophe Rochet, Chongli Yuan, Layan Yunis, J Marshall Shafer, Maria I. Olivero-Acosta, Muriel Eaton, Zhefu Que, Junkai Xie, Anke M Tukker, Jingliang Zhang, Tiange Xiao, Zhuo Huang, Chang-Deng Hu, Kyle Wettschurack, Jiaxiang Wu, Yang Yang, William C. Skarnes, Aaron B. Bowman, James A. Schaber, Darci J. Trader
Publikováno v:
J Neurosci
With the wide adoption of genomic sequencing in children having seizures, an increasing number ofSCN2Agenetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by geneSCN2A, is predominantly expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b6115697095c83c5641e97b58120f
https://doi.org/10.1523/jneurosci.0564-21.2021
https://doi.org/10.1523/jneurosci.0564-21.2021
Autor:
Anke M. Tukker, Misha F. Vrolijk, Regina G.D.M. van Kleef, Dick T.H.M. Sijm, Remco H.S. Westerink
Publikováno v:
Toxicology Letters, 373, 53-61. Elsevier Ireland Ltd
Tetrodotoxin (TTX) potently inhibits TTX-sensitive voltage-gated sodium (Na V) channels in nerve and muscle cells, potentially resulting in depressed neurotransmission, paralysis and death from respiratory failure. Since a wide range of pharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a8304d44fc895fe72e824d2985c38f
https://pubmed.ncbi.nlm.nih.gov/36375636
https://pubmed.ncbi.nlm.nih.gov/36375636
Publikováno v:
Toxicol Sci
Environmental factors and gene-environment interactions modify the variable expressivity, progression, severity, and onset of some classic (monogenic) Mendelian-inherited genetic diseases. Cystic fibrosis, Huntington disease, Parkinson’s disease, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a46d27c4ba726c2b3e2a85beb810916
https://doi.org/10.1093/toxsci/kfab022
https://doi.org/10.1093/toxsci/kfab022
Autor:
Jyothi Thimmapuram, Shaojun Xie, Aaron B. Bowman, Hyunjin Kim, Anke M Tukker, M. Diana Neely, Lisa M. Prince, Michael Aschner
Publikováno v:
Food Chem Toxicol
The developing human brain is uniquely vulnerable to methylmercury (MeHg) resulting in lasting effects especially in developing cortical structures. Here we assess by single-cell RNA sequencing (scRNAseq) persistent effects of developmental MeHg expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d100d676d3eb6a9a96d547cf3c971e5e
https://doi.org/10.1016/j.fct.2021.112288
https://doi.org/10.1016/j.fct.2021.112288
Autor:
Remco H.S. Westerink, Regina G.D.M. van Kleef, Anke M Tukker, Aart de Groot, Fiona M J Wijnolts
Publikováno v:
ALTEX.
A sizeable proportion of drug attrition is due to drug-induced seizures. Current available animal models frequently fail to predict human seizure liability. Therefore, there is a need for in vitro alternatives, preferably based on human-derived neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973726e3c3cada3c569483492ea9f106
https://doi.org/10.14573/altex.1907121
https://doi.org/10.14573/altex.1907121