Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anke M. Schulte"'
Autor:
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104625- (2023)
Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress
Externí odkaz:
https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4
Autor:
David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu, on behalf of the INNODIA consortium
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background The INNODIA consortium has established a pan-European infrastructure using validated centres to prospectively evaluate clinical data from individuals with newly diagnosed type 1 diabetes combined with centralised collection of cli
Externí odkaz:
https://doaj.org/article/579881137eaa49e583e9b682b21fba96
Autor:
Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 98-107 (2019)
Objective: Genome wide association studies (GWAS) for type 2 diabetes (T2D) have identified genetic loci that often localise in non-coding regions of the genome, suggesting gene regulation effects. We combined genetic and transcriptomic analysis from
Externí odkaz:
https://doaj.org/article/4af5880333534cc4945b84659e1128a8
Autor:
Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L. Eizirik, Miriam Cnop, Piero Marchetti
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108466- (2020)
Summary: Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient
Externí odkaz:
https://doaj.org/article/28763563ad6f4edd9dcabcb486fa39a2
Autor:
Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S1-S6 (2019)
Background: The availability of human pancreatic islets with characteristics closely resembling those present in vivo is instrumental for ex vivo studies in diabetes research. Scope of review: In this review we propose metabolically phenotyped surgic
Externí odkaz:
https://doaj.org/article/27eadfe1b5f5459f8f06ef5d97dcf57c
Autor:
Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine FA Bruggraber, M Loredana Marcovecchio, Emile Hendricks, Naba Al-Sari, Ismo Mattila, Cristina Legido-Quigley, Tommi Suvitaival, Piotr J Chmura, Mikael Knip, Anke M Schulte, Jeong Heon Lee, Guido Sebastiani, Giuseppina Emanuela Grieco, Laura L Elo, Simranjeet Kaur, Flemming Pociot, Francesco Dotta, Tim Tree, Riitta Lahesmaa, Lut Overbergh, Chantal Mathieu, Mark Peakman, Søren Brunak
BackgroundHeterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative analyses of complementary multi-om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aed4945812f6d48199ab6c18d691d46
https://doi.org/10.1101/2023.03.22.23287261
https://doi.org/10.1101/2023.03.22.23287261
Autor:
Charlotte S Wilhelm-Benartzi, Sarah E Miller, Sylvaine Bruggraber, Diane Picton, Mark Wilson, Katrina Gatley, Anita Chhabra, M Loredana Marcovecchio, A Emile J Hendriks, Hilde Morobé, Piotr Jaroslaw Chmura, Simon Bond, Bärbel Aschemeier-Fuchs, Mikael Knip, Timothy Tree, Lut Overbergh, Jaivier Pall, Olivier Arnaud, Michael J Haller, Almut Nitsche, Anke M Schulte, Chantal Mathieu, Adrian Mander, David Dunger
Publikováno v:
BMJ Open
Wilhelm-Benartzi, C S, Miller, S E, Bruggraber, S, Picton, D, Wilson, M, Gatley, K, Chhabra, A, Marcovecchio, M L, Hendriks, A E J, Morobé, H, Chmura, P J, Bond, S, Aschemeier-Fuchs, B, Knip, M, Tree, T, Overbergh, L, Pall, J, Arnaud, O, Haller, M J, Nitsche, A, Schulte, A M, Mathieu, C, Mander, A & Dunger, D 2021, ' Study protocol Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG) : Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes ', BMJ Open, vol. 11, no. 12, e053669 . https://doi.org/10.1136/bmjopen-2021-053669
BMJ OPen
Wilhelm-Benartzi, C S, Miller, S E, Bruggraber, S, Picton, D, Wilson, M, Gatley, K, Chhabra, A, Marcovecchio, M L, Hendriks, A E J, Morobé, H, Chmura, P J, Bond, S, Aschemeier-Fuchs, B, Knip, M, Tree, T, Overbergh, L, Pall, J, Arnaud, O, Haller, M J, Nitsche, A, Schulte, A M, Mathieu, C, Mander, A & Dunger, D 2021, ' Study protocol Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG) : Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes ', BMJ Open, vol. 11, no. 12, e053669 . https://doi.org/10.1136/bmjopen-2021-053669
BMJ OPen
• Introduction: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin-producing β cells of the pancreas. One immunosuppressive agent that has recently shown promise in the treatment of new-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0f7f45d778801769d91a723bd536ad
Autor:
Cristina Legido-Quigley, Florence Mehl, Daniela Aust, Eyke Schöniger, Kai Simons, Mathias Lesche, Michele Solimena, Andreas Dahl, Marko Barovic, Nicole Kipke, Flavia Marzetta, Anke M. Schulte, Andreas-David Brunner, Matthias Mann, Daniela Friedland, Jürgen Weitz, Frédéric Burdet, Philippe Delerive, Christian Klose, Bernard Thorens, Mark Ibberson, Marius Distler, Mathias J. Gerl, Pierre Barbier Saint Hilaire, Leonore Wigger, Ezio Bonifacio, Camille Kessler
Publikováno v:
Nature Metabolism
Nat. Metab. 3, 1017–1031 (2021)
Nat. Metab. 3, 1017–1031 (2021)
Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or diseased brain-dead donors and thus cannot accurately describe the molecular changes of pancreatic islet beta cells as they progress towards a state of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0a2de893c0f7383454822394989fff
https://hdl.handle.net/21.11116/0000-0009-C4F9-1
https://hdl.handle.net/21.11116/0000-0009-C4F9-1
Autor:
Anke M. Schulte, Søren Brunak, Simranjeet Kaur, Gianluca Mazzoni, Chantal Mathieu, Jose Juan Almagro Armenteros, Caroline Brorsson
Publikováno v:
Diabetes. 70
Background: Development of disease-modifying therapy for type 1 diabetes (T1D) is hampered by the limited understanding of pathogenesis, heterogeneity, lack of disease biomarkers and stratifiers. Using the INNODIA consortium pan-European infrastructu
Autor:
Inês Cebola, Michele Solimena, Mickaël Canouil, Paul Gadue, Guy A. Rutter, Sameena Nawaz, Piero Marchetti, Leonardo Alemeida-Souza, Amna Khamis, Anke M. Schulte, Harvey T. McMahon, Gaelle Carrat, Benoit Hastoy, Shuying Jiang, Ming Hu, Fabian L. Cardenas-Diaz, Philippe Froguel, Mark Ibberson
Publikováno v:
Cell Reports
Cell Rep. 34:108703 (2021)
Cell Rep. 34:108703 (2021)
Summary Using chromatin conformation capture, we show that an enhancer cluster in the STARD10 type 2 diabetes (T2D) locus forms a defined 3-dimensional (3D) chromatin domain. A 4.1-kb region within this locus, carrying 5 T2D-associated variants, phys