Výsledky vyhledávání - "Anke Lührmann"

Beneficial Effects of TLR-2/6 Ligation in Pulmonary Bacterial Infection and Immunization with Pseudomonas aeruginosa

Autor: Damaris Leemhuis, Anke Lührmann, Reinhard Pabst, Burkhard Tümmler, Tanja Kerber-Momot, Thomas Tschernig, Antje Munder

Publikováno v: Inflammation. 33:58-64

Pseudomonas aeruginosa (P. aeruginosa) is the major pathogen in nosocomial and life-threatening infections of immunocompromised or critically ill patients. The macrophage-activating lipopeptide-2 (MALP-2) activates the immune system via Toll-like rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d1b1a734e3ba04fd5c3b20bb6127c7
https://doi.org/10.1007/s10753-009-9158-7

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Kinetics of Regulatory T Cells in the Ovalbumin Asthma Model in the Rat

Autor: Anke Lührmann, Reinhard Pabst, Thomas Tschernig, Marie-Charlot Jurawitz

Publikováno v: International Archives of Allergy and Immunology. 149:16-24

Background: The kinetics of regulatory T cells (TReg) in allergic diseases such as asthma are only partly known. Methods: The asthma model in the Fischer rat with ovalbumin (OVA) sensitization and aerosol challenge was used. The relative and absolute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e4a6a199b0713edd7e2b1a78353eda
https://doi.org/10.1159/000176302

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Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse

Autor: Reinhard Pabst, Katrin S. Lips, Thomas Tschernig, Wolfgang Kummer, Hermann Koepsell, Francesca Alessandrini, Veronika Grau, Tobias Stoeger, Rainer Viktor Haberberger, Anke Lührmann

Publikováno v: Life Sciences. 80:2263-2269

Acetylcholine (ACh), derived both from nerve fibres and from non-neuronal sources such as epithelial cells, is a major regulator of airway function. There is evidence that dysfunction of the neuronal cholinergic system is involved in the pathogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d7679f997c46dae4585d557970d33c
https://doi.org/10.1016/j.lfs.2007.01.026

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Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2

Autor: Reinhard Pabst, Anke Lührmann, Stefan Niewiesk, Thomas Tschernig

Publikováno v: Vaccine. 23:4721-4726

The macrophage-activating lipopeptide with a molecular weight of 2kDa (MALP-2) activates antigen presenting cells of human, mouse and rat origin in vitro and in vivo. Here, we demonstrate that MALP-2 induces MIP1alpha and beta, MIP-2, Gro, TNFalpha,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bdb5abd645e92d68afc2557f86c2b2
https://doi.org/10.1016/j.vaccine.2005.05.009

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Effects of cilomilast on dendritic cell function in contact sensitivity and dendritic cell migration through skin

Autor: Anke Lührmann, Ulrike Seegers, Boris Sülzle, Thomas Tschernig, Wolfgang Bäumer, Manfred Kietzmann

Publikováno v: European Journal of Pharmacology. 481:271-279

The phosphodiesterase 4 inhibitor cilomilast demonstrated strong inhibitory effects in a model of allergic contact dermatitis. In this study, we examined whether this inhibitory effect is at least partly due to modulation of dendritic cell function.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0989d89e1aa39b06ef565d4e0e22c65
https://doi.org/10.1016/j.ejphar.2003.09.031

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In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide ofMycoplasma fermentansafter Pulmonary Application

Autor: Reinhard Pabst, Johannes E. Gessner, Julia Skokowa, Peter F. Mühlradt, Thomas Tschernig, Ursula Deiters, Anke Lührmann, Michaela Hanke

Publikováno v: Infection and Immunity. 70:3785-3792

Mycoplasmas can cause interstitial pneumonias inducing critical illness in humans and animals. Mycoplasma infections are characterized by an influx of neutrophils, followed by an accumulation of macrophages and lymphocytes. The present study deals wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df49dbde4d0d70d3c7c0ea7e31974418
https://doi.org/10.1128/iai.70.7.3785-3792.2002

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Pulmonary microbial infection in mice: Comparison of different application methods and correlation of bacterial numbers and histopathology

Autor: S. Krusch, Thomas Tschernig, Siegfried Weiss, Anke Lührmann, Burkhard Tümmler, Hans-Jürgen Hedrich, Martina Dorsch, M. van Griensven, Antje Munder

Publikováno v: Scopus-Elsevier

Summary Many investigations have been performed in characterising experimental bacterial infections in the lung of mice using several pathogens. Robust experimental pulmonary infection models require a reproducible method of application with defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3134315809f41b750230c7556fa0ef17
https://doi.org/10.1078/0940-2993-00240

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Recruitment of Lymphocytes and Dendritic Cells from the Blood to the Bronchoalveolar Space and the Draining Lymph Nodes after a Single Intrabronchial Application of the Lipopeptide MALP-2

Autor: Anke Lührmann, Reinhard Pabst, Thomas Tschernig

Publikováno v: Pathobiology. 70:260-265

Objective: It has been shown previously that the synthetic macrophage-activating lipopeptide, MALP-2, is a potent stimulator of the respiratory immune system and an effective adjuvant in the induction of mucosal immune responses. In this study, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dbc5e4c441653ced63831765fb2bbb
https://doi.org/10.1159/000070739

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