Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

Autor: Sylvia Bolz, Simon J. Clark, Michela Deleidi, Inga Sonntag, Vasiliki Panagiotakopoulou, Anke Jacob, Sabina Honisch, Ellen Kilger, Marius Ueffing, Angela Armento

Publikováno v: Scientific Reports
Scientific reports 10(1), 10320 (2020). doi:10.1038/s41598-020-67292-z
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to compleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b7a6a57d9bcee7f8d8cf617090f2b6
https://pubmed.ncbi.nlm.nih.gov/32587311

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

Autor: Sandra N. Freiberger, Tassula Proikas-Cezanne, Patrice Codogno, Anke Jacob, Katharina Hentschel, Mario Mauthe, York-Dieter Stierhof

Publikováno v: Autophagy, 7(12), 1448-1461. Taylor & Francis Group

Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3-phosphate (PtdIns(3)P), for the formation of autophagosomes. Pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bea5b882a44cd176bf65d7920d7f7a
https://doi.org/10.4161/auto.7.12.17802