Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Autor: George D. Mcilroy, Karla Suchacki, Anke J. Roelofs, Wulin Yang, Yanyun Fu, Bo Bai, Robert J. Wallace, Cosimo De Bari, William P. Cawthorn, Weiping Han, Mirela Delibegović, Justin J. Rochford

Publikováno v: Molecular Metabolism, Vol 10, Iss , Pp 55-65 (2018)

Objective: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic

Externí odkaz: https://doaj.org/article/f1fe08833cf9437a8e9830d0475e85b6

Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model

Autor: Jade Perry, Anke J. Roelofs, Claire Mennan, Helen S. McCarthy, Alison Richmond, Susan M. Clark, Anna H. K. Riemen, Karina Wright, Cosimo De Bari, Sally Roberts

Publikováno v: Cells, Vol 10, Iss 8, p 1999 (2021)

Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could enhance healing of chondral defects with or without th

Externí odkaz: https://doaj.org/article/7728aff2422f4e3e9ad93776dd2b2f42

Spatial Lipidomic Profiling of Mouse Joint Tissue Demonstrates the Essential Role of PHOSPHO1 in Growth Plate Homeostasis

Autor: Jordan Tzvetkov, Louise A. Stephen, Scott Dillon, Jose Luis Millan, Anke J. Roelofs, Cosimo De Bari, Colin Farquharson, Tony Larson, Paul Genever

Funder: Biotechnology and Biological Sciences Research Council; Id: http://dx.doi.org/10.13039/501100000268
Funder: Versus Arthritis; Id: http://dx.doi.org/10.13039/501100012041
Lipids play a crucial role in signaling and metabolism, regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e77c804a784d713f2da712d1f547adc
https://www.repository.cam.ac.uk/handle/1810/347571

BMP signaling: A significant player and therapeutic target for osteoarthritis

Autor: H. Wang, Anna H. K. Riemen, Nanasaheb Sv, Jaswal Ap, De Bari C, Kumar B, Agnihotri N, Anke J. Roelofs, Avinash Singh, Iqbal Sf, Ashraf S, Amitabha Bandyopadhyay

ObjectiveTo investigate the role of BMP signaling in osteoarthritis' pathogenesis and propose a disease-modifying therapy for OA.MethodsC57BL6/J mouse line was used to perform ACLT surgery at P120 to study the expression pattern of the BMP signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::046da4194146d197d86d62f4e28f3191
https://doi.org/10.1101/2021.03.01.433366

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Autor: Thomas Aigner, Karolina Kania, Kenneth A. Howard, Anke J. Roelofs, H. Wang, Francesco Dell'Accio, Cosimo De Bari, Fabio Colella, Anna H. K. Riemen, Terence D. Capellini

Publikováno v: Scientific Reports
Kania, K, Colella, F, Riemen, A H K, Wang, H, Howard, K, Aigner, T, Dell’Accio, F, Capellini, T D, Roelofs, A J & De Bari, C 2020, ' Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis ', Scientific Reports, vol. 10, no. 1, 157, pp. 157 . https://doi.org/10.1038/s41598-019-57011-8
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA). However, little is known regarding regulation of Gdf5 expression following joint tissue damage. Here, we employed Gdf5-LacZ reporter mouse lines to assess the spa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e3b7a32e4bf9249b6ab4408a28c8d
http://europepmc.org/articles/PMC6957535