Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anke Hofmeister-Brix"'
Publikováno v:
Biochemical pharmacology. 168
Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered by an incomplete underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbf16847b12d4202852c5d786539f9e
https://pubmed.ncbi.nlm.nih.gov/31254492
https://pubmed.ncbi.nlm.nih.gov/31254492
Autor:
Sara Langer, Simone Baltrusch, Katrin Kollmann, Sigurd Lenzen, Julia Schultz, Anke Hofmeister-Brix
Publikováno v:
Journal of Biological Chemistry. 288:35824-35839
Glucokinase acts as a glucose sensor in pancreatic beta cells. Its posttranslational regulation is important but not yet fully understood. Therefore, a pancreatic islet yeast two-hybrid library was produced and searched for glucokinase-binding protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebf9c2ef972925a8cef4905540a1290
https://doi.org/10.1074/jbc.m113.526632
https://doi.org/10.1074/jbc.m113.526632
Publikováno v:
Biochemical Journal. 456:173-184
The ubiquitin–proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin secretion. Key regulators of the stimulus/secretion cascade seem to be affected by prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa03a101d732173f57732ebf0a8120f
https://doi.org/10.1042/bj20130262
https://doi.org/10.1042/bj20130262