Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

Autor: Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff

Publikováno v: Cell Reports, Vol 30, Iss 7, Pp 2261-2274.e7 (2020)

Summary: The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activati

Externí odkaz: https://doaj.org/article/03906fd8cd7840c89119e99657af1d0a

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

Autor: Nichole R Klatt, Steven E Bosinger, Melicent Peck, Laura E Richert-Spuhler, Anke Heigele, Jillian P Gile, Nirav Patel, Jessica Taaffe, Boris Julg, David Camerini, Carlo Torti, Jeffrey N Martin, Steven G Deeks, Elizabeth Sinclair, Frederick M Hecht, Michael M Lederman, Mirko Paiardini, Frank Kirchhoff, Jason M Brenchley, Peter W Hunt, Guido Silvestri

Publikováno v: PLoS Pathogens, Vol 10, Iss 8, p e1004345 (2014)

A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotyp

Externí odkaz: https://doaj.org/article/eef74e25784f450da0159e4e5b448876

Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

Autor: Sydney A. Nelson, Kerstin Mätz-Rensing, Christiane Stahl-Hennig, Simone Joas, Anke Heigele, Luis D. Giavedoni, Ulrike Sauermann, Daniel Sauter, Guido Silvestri, Antonina Klippert, Prachi Mehrotra Gupta, Berit Roshani, Frank Kirchhoff, Gregory K. Tharp, Laura M. Parodi, Maria Daskalaki, Steven E. Bosinger, Nicole Stolte-Leeb

Publikováno v: Cell reports
Cell Reports, Vol 30, Iss 7, Pp 2261-2274.e7 (2020)

SUMMARY The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0874d5b30151f28b355e7fc47f3fbdfc
https://pubmed.ncbi.nlm.nih.gov/32075764

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

Autor: Martine Peeters, Frank Kirchhoff, Christina M. Stürzel, Lukas Peiffer, Dorota Kmiec, Beatrice H. Hahn, Massimo Pizzato, Kerstin Regensburger, Daniel Sauter, Gerald H. Learn, Anke Heigele, Simon Langer

The cellular factor serine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein. We analyzed the anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 represents a bar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad9f862f9b4b5fff5266ae5069aae6e
http://hdl.handle.net/11572/174869

Cell Rep

Autor: Onofrio, Zirafi, Kyeong-Ae, Kim, Ludger, Ständker, Katharina B, Mohr, Daniel, Sauter, Anke, Heigele, Silvia F, Kluge, Eliza, Wiercinska, Doreen, Chudziak, Rudolf, Richter, Barbara, Moepps, Peter, Gierschik, Virag, Vas, Hartmut, Geiger, Markus, Lamla, Tanja, Weil, Timo, Burster, Andreas, Zgraja, Francois, Daubeuf, Nelly, Frossard, Muriel, Hachet-Haas, Fabian, Heunisch, Christoph, Reichetzeder, Jean-Luc, Galzi, Javier, Pérez-Castells, Angeles, Canales-Mayordomo, Jesus, Jiménez-Barbero, Guillermo, Giménez-Gallego, Marion, Schneider, James, Shorter, Amalio, Telenti, Berthold, Hocher, Wolf-Georg, Forssmann, Halvard, Bonig, Frank, Kirchhoff, Jan, Münch

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2015, 11 (5), pp.737-747. ⟨10.1016/j.celrep.2015.03.061⟩
Cell Reports, Vol 11, Iss 5, Pp 737-747 (2015)
Oncotarget

International audience; CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::38f5e83f74311f248b386430d20e6014
https://hdl.handle.net/21.11116/0000-0001-ACC5-F21.11116/0000-0001-ACC0-4