Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anke Harsman"'
Autor:
Corinne von Känel, Sergio A Muñoz-Gómez, Silke Oeljeklaus, Christoph Wenger, Bettina Warscheid, Jeremy G Wideman, Anke Harsman, Andre Schneider
Publikováno v:
eLife, Vol 9 (2020)
Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner membrane is provided by the presequence translocase-associated motor (PAM) which contains t
Externí odkaz:
https://doaj.org/article/9c4bc4289c1c4c3c85fd4f7b63d6d87a
Autor:
Christian D. Peikert, Jan Mani, Marcel Morgenstern, Sandro Käser, Bettina Knapp, Christoph Wenger, Anke Harsman, Silke Oeljeklaus, André Schneider, Bettina Warscheid
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Knowing the specific protein content of individual organelles is necessary for an integrated understanding of cellular physiology. Here the authors describe a mass spectrometry-based approach to identify the substrates of distinct protein import path
Externí odkaz:
https://doaj.org/article/bf7073abf7dd409ea6d6cecc74034615
Autor:
Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The mitochondrial protein import machinery is crucial for eukaryotes but little is known about its evolutionary origin. Here, the authors characterize the translocase of the inner membrane (TIM) in trypanosomes, showing that it contains two rhomboid-
Externí odkaz:
https://doaj.org/article/71e9d79a4a73445c930fdcca41bf6ec0
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006550 (2017)
Mitochondrial protein import is essential for Trypanosoma brucei across its life cycle and mediated by membrane-embedded heterooligomeric protein complexes, which mainly consist of trypanosomatid-specific subunits. However, trypanosomes contain ortho
Externí odkaz:
https://doaj.org/article/467563981f704ad3a7a11b3439f25d59
Autor:
Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number:13707 (2016); Published: 19 December 2016; Updated: 30 June 2017 The original version of this Article contained an error in the gene ID for TimRhom I, cited in the Methods, which specified an unrelated gene. Th
Externí odkaz:
https://doaj.org/article/69edd1feb5384e1fb09d28c9a19f7823
Autor:
Grazyna Domańska, Christian Motz, Michael Meinecke, Anke Harsman, Panagiotis Papatheodorou, Boris Reljic, Elke A Dian-Lothrop, Antoine Galmiche, Oliver Kepp, Lars Becker, Kathrin Günnewig, Richard Wagner, Joachim Rassow
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000878 (2010)
The vacuolating toxin VacA, released by Helicobacter pylori, is an important virulence factor in the pathogenesis of gastritis and gastroduodenal ulcers. VacA contains two subunits: The p58 subunit mediates entry into target cells, and the p34 subuni
Externí odkaz:
https://doaj.org/article/a4b5be66caac4e40b235c363349940c3
Autor:
Vera Kozjak-Pavlovic, Elke A Dian-Lothrop, Michael Meinecke, Oliver Kepp, Katharina Ross, Krishnaraj Rajalingam, Anke Harsman, Eva Hauf, Volker Brinkmann, Dirk Günther, Ines Herrmann, Robert Hurwitz, Joachim Rassow, Richard Wagner, Thomas Rudel
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000629 (2009)
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochond
Externí odkaz:
https://doaj.org/article/4eb02a599a174a6bae497f14f7e016cf
Autor:
Christoph Wenger, Anke Harsman, Moritz Niemann, Silke Oeljeklaus, Corinne von Känel, Salvatore Calderaro, Bettina Warscheid, André Schneider
Publikováno v:
Molecular Microbiology. 119:537-550
Autor:
Christoph Wenger, Anke Harsman, Moritz Niemann, Silke Oeljeklaus, Corinne von Känel, Salvatore Calderaro, Bettina Warscheid, André Schneider
Consistent with other eukaryotes, theTrypanosoma bruceimitochondrial genome encodes mainly hydrophobic core subunits of the oxidative phosphorylation system. These proteins must be co-translationally inserted into the inner mitochondrial membrane and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd5584b4e3c11e2936ce8ea9d9f052af
https://doi.org/10.1101/2022.12.21.521360
https://doi.org/10.1101/2022.12.21.521360
Publikováno v:
Molecular microbiology. 102(3)
TbLOK1 has previously been characterized as a trypanosomatid-specific mitochondrial outer membrane protein whose ablation caused a collapse of the mitochondrial network, disruption of the membrane potential and loss of mitochondrial DNA. Here we show