Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

Autor: Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)

Background Immunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL. We aimed to tackle one of the most notable

Externí odkaz: https://doaj.org/article/7142ba69053342a98bcc3622acf2b968

Decitabine mildly attenuatesMLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

Autor: Ronald W. Stam, M. Emmy M. Dolman, Anke H. W. Essing, Pauline Schneider, Mark Kerstjens, Rob Pieters, P. Castro, Jan J. Molenaar, Sandra S Mimoso Pinhancos, Eddy H.J. van Roon

Publikováno v: eJHaem. 1:527-536

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f7019de76379a12def59d98c8470b36
https://doi.org/10.1002/jha2.81

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

Autor: Celso Henrique Alves, Koen Bossers, Rogier M Vos, Anke H W Essing, Sigrid Swagemakers, Peter J van der Spek, Joost Verhaagen, Jan Wijnholds

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82532 (2013)

In humans, the Crumbs homologue-1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber congenital amaurosis. The severity of the phenotype due to human CRB1 or mouse Crb1 mutations is dependent on the gene

Externí odkaz: https://doaj.org/article/8cc487749150411fbefec8945a025999

Decitabine mildly attenuates

Autor: Pauline, Schneider, Patricia Garrido, Castro, Sandra M, Pinhanços, Mark, Kerstjens, Eddy H, van Roon, Anke H W, Essing, M Emmy M, Dolman, Jan J, Molenaar, Rob, Pieters, Ronald W, Stam

Publikováno v: EJHaem. 1(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61f91abf8deee32db4707a6eda54deb4
https://pubmed.ncbi.nlm.nih.gov/35844991

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Autor: Dieter Deforce, Dries Rombaut, Karen Verboom, Jan J. Molenaar, Suzanne Vanhauwaert, Pieter Mestdagh, Johan van Nes, G Schleiermacher, Bieke Decaesteker, Johannes H. Schulte, Filip Van Nieuwerburgh, Franki Speleman, Christophe Van Neste, Rogier Versteeg, Jolien De Wyn, Carl Herrmann, Katleen De Preter, Geertrui Denecker, Moritz Gartlgruber, Kaat Durinck, Daniel Dreidax, Pauline Depuydt, Fanny De Vloed, Valentina Boeva, Wouter Van Loocke, Waleed M. Kholosy, Frank Westermann, Bianca Koopmans, Emmy Dolman, Anke H. W. Essing, Carolina de Carvalho Nunes, Siebe Loontiens, Anton G. Henssen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature communications, 9(1). Nature Publishing Group
NATURE COMMUNICATIONS

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e8858a0341eef79ecb61df7ffcf5b
https://doaj.org/article/536b907629694780b1f507b113373066