Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Anke Eggers"'
Autor:
Willhart Knepel, R. Blume, Elke Oetjen, Doris Krause, Anke Eggers, Michael Seeger, Daniela Grapentin
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 367(3)
Cyclosporin A and tacrolimus are important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. In a single study, tacrolimus (100 nM) inhibited human insulin gene transcription in the beta-cell line
cAMP increases transcription of the mitochondrial (mit.) gene for 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, which encodes an enzyme that has been proposed as a control site of ketogenesis. The incubation of Caco-2 cells with cAMP increased mit.H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43300116a8103f090d95eda59abae122
https://europepmc.org/articles/PMC1220747/
https://europepmc.org/articles/PMC1220747/
Publikováno v:
The Journal of biological chemistry. 273(29)
Cyclic AMP stimulates insulin gene transcription through a cAMP response element (CRE). In the present study the insulin CRE-binding proteins and their functions were investigated. A mutational analysis of nuclear protein binding in electrophoretic m
Publikováno v:
The Journal of biological chemistry. 269(43)
The cAMP response element (CRE)-binding transcription factor CREB can mediate induction of gene transcription in response to calcium as well as to cAMP. Since the rat insulin I gene 5'-flanking region contains a CRE with an octamer-like motif (TGACGT