Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anke E. J. 't Jong"'
Autor:
Xiaoyu Chen, Josephine M. Janssen, Jin Liu, Ignazio Maggio, Anke E. J. ‘t Jong, Harald M.M. Mikkers, Manuel A. F. V. Gonçalves
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DN
Externí odkaz:
https://doaj.org/article/60102009427545b88a37146eedf8137c
Autor:
Raissa Timmerman, Ella A. Zuiderwijk‐Sick, Nynke Oosterhof, Anke E. J. 't Jong, Jennifer Veth, Saskia M. Burm, Tjakko J. van Ham, Jeffrey J. Bajramovic
Publikováno v:
Glia, 70(4), 728-747. Wiley
GLIA, 70(4), 728-747. John Wiley & Sons Inc.
GLIA, 70(4), 728-747. John Wiley & Sons Inc.
Microglia are increasingly being recognized as druggable targets in neurodegenerative disorders, and good in vitro models are crucial to address cell biological questions. Major challenges are to recapitulate the complex microglial morphology and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8c9ebb6fc2c7a0034b330fbd03e7db
https://pubmed.ncbi.nlm.nih.gov/34961968
https://pubmed.ncbi.nlm.nih.gov/34961968
Autor:
Harald Mikkers, Xiaoyu Chen, Anke E. J. ‘t Jong, Manuel A F V Gonçalves, Ignazio Maggio, Josephine M. Janssen, Jin Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, 8
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, 8
Precise genome editing involves homologous recombination between donor DNA and chromosomal sequences subjected to double-stranded DNA breaks made by programmable nucleases. Ideally, genome editing should be efficient, specific, and accurate. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bba66e42b51a01c2c87061229fbabf
https://doi.org/10.1038/s41467-017-00687-1
https://doi.org/10.1038/s41467-017-00687-1