Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anke Detzer"'
Autor:
Miriam Mende, Anke Detzer, Marita Overhoff, Anne Hopert, Georg Sczakiel, Holger Kirchner, Kirsten Börngen, Peter Schlenke, Winfried Wünsche
Publikováno v:
Immunology. 120:261-272
Summary The relationship between immunostimulation of human B cells by cytosine–phosphate–guanosine (CpG) -containing oligonucleotides and their physical cellular uptake is of mechanistic interest and a prerequisite for rational improvements of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce238920a4abfb45eb927ba21d9c1ab
https://doi.org/10.1111/j.1365-2567.2006.02497.x
https://doi.org/10.1111/j.1365-2567.2006.02497.x
Publikováno v:
Nucleic Acids Research
Various kinds of stress on human cells induce the formation of endogenous stress granules (SGs). Human Argonaute 2 (hAgo2), the catalytic core component of the RNA-induced silencing complex (RISC), can be recruited to SGs as well as P-bodies (PBs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc328ac56aa14cfd2b6d43739156c19
https://pubmed.ncbi.nlm.nih.gov/21148147
https://pubmed.ncbi.nlm.nih.gov/21148147
Autor:
Maximilian J. Hahnel, Georg Sczakiel, Ulrike Weirauch, Anke Detzer, Alessandra Mescalchin, Christina Engel
Publikováno v:
RNA (New York, N.Y.). 16(12)
The Argonaute proteins play essential roles in development and cellular metabolism in many organisms, including plants, flies, worms, and mammals. Whereas in organisms such as Caenorhabditis elegans and Arabidopsis thaliana, creation of Argonaute mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0300eb7834cf5f165fd52cd2837a885d
https://pubmed.ncbi.nlm.nih.gov/20935067
https://pubmed.ncbi.nlm.nih.gov/20935067
Publikováno v:
RNA Technologies and Their Applications ISBN: 9783642121678
RNA-based therapeutic strategies are considered as a highly promising alternative to conventional drug development. Among the different classes of oligonucleotide-derived prospective drugs, small interfering RNAs (siRNAs) are of particular interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb345ecb57f681f7426f819d3a13e0ba
https://doi.org/10.1007/978-3-642-12168-5_2
https://doi.org/10.1007/978-3-642-12168-5_2
Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide
Autor:
Michael J. Gait, Georg Sczakiel, Gabriela D. Ivanova, John J. Turner, Winfried Wünsche, Marita Overhoff, Maria Rompf, Anke Detzer
Publikováno v:
RNA (New York, N.Y.). 15(4)
In the last decade short interfering RNA (siRNA) became an important means for functional genomics and the development of gene-specific drugs. However, major technical hurdles in the application of siRNA include its cellular delivery followed by its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa9f9196707917cbb78f1952c6b8e15
https://pubmed.ncbi.nlm.nih.gov/19228587
https://pubmed.ncbi.nlm.nih.gov/19228587
Publikováno v:
Current pharmaceutical design. 14(34)
The phosphorothioate(PS)-stimulated cellular uptake of naked short interfering RNA (siRNA) into mammalian cells indicates a promising new mechanistic strategy because it makes use of a caveosomal, rather than an endosomal pathway, which is used by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2ec85d73a4fc78ed7cd84fa9d81018
https://pubmed.ncbi.nlm.nih.gov/19075742
https://pubmed.ncbi.nlm.nih.gov/19075742
Autor:
Marita Overhoff, Georg Sczakiel, Maria Wecke, Winfried Wünsche, Anke Detzer, Alessandra Mescalchin
Publikováno v:
Expert opinion on biological therapy. 7(10)
The cellular uptake of oligomeric nucleic acid-based tools and drugs including small-interfering RNA (siRNA) represents a major technical hurdle for the biologic effectiveness and therapeutic success in vivo. Subsequent to cellular delivery it is cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2a63b0d8cccf0492be3359d4e8a2e1
https://pubmed.ncbi.nlm.nih.gov/17916045
https://pubmed.ncbi.nlm.nih.gov/17916045
Autor:
Anke Detzer, Mike Gait, John J. Turner, Winfried Wünsche, Georg Sczakiel, Marita Overhoff, Maria Wecke
Publikováno v:
GBM Fall meeting Hamburg 2007. 2007
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd64840e1a2693de8ac5e4389497906c
https://doi.org/10.1240/sav_gbm_2007_h_001967
https://doi.org/10.1240/sav_gbm_2007_h_001967