Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anke Altkrüger"'
Autor:
Sandra Schubert, Klaus-Peter Knoch, Joke Ouwendijk, Shabaz Mohammed, Yury Bodrov, Melanie Jäger, Anke Altkrüger, Carolin Wegbrod, Marvin E Adams, Yong Kim, Stanley C Froehner, Ole N Jensen, Yannis Kalaidzidis, Michele Solimena
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12929 (2010)
The molecular basis for the interaction of insulin granules with the cortical cytoskeleton of pancreatic β-cells remains unknown. We have proposed that binding of the granule protein ICA512 to the PDZ domain of β2-syntrophin anchors granules to act
Externí odkaz:
https://doaj.org/article/5d0da52b8e9b4c528ee12740e508caba
Autor:
Hans-Detlev Saeger, Anke Altkrüger, Michele Solimena, Hendrik Bergert, Stephan Kersting, Melanie Jäger, Klaus-Peter Knoch, C. Wegbrod, Ronny Meisterfeld
Publikováno v:
Cell Metabolism. 3(2):123-134
Summary Glucose stimulates the exocytosis of insulin secretory granules of pancreatic β cells. Granule stores are quickly refilled by activation of posttranscriptional mechanisms that enhance the biosynthesis of granule components. Rapid replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea22b6fb374524c6ab718fe70fb2842
Autor:
Michele Solimena, Klaus-Peter Knoch, Paul Verkade, Hans-Detlev Saeger, Hendrik Bergert, Barbara Borgonovo, Anke Altkrüger
Publikováno v:
Nature Cell Biology. 6:207-214
Pancreatic beta-cells store insulin in secretory granules that undergo exocytosis upon glucose stimulation. Sustained stimulation depletes beta-cells of their granule pool, which must be quickly restored. However, the factors promoting rapid granule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f856babd5c6d98ad4841673e5ac3079
https://doi.org/10.1038/ncb1099
https://doi.org/10.1038/ncb1099
Autor:
Ole N. Jensen, Melanie Jäger, Michele Solimena, Marvin E. Adams, Joke Ouwendijk, Sandra Schubert, Anke Altkrüger, Klaus Peter Knoch, Carolin Wegbrod, Stanley C. Froehner, Yury Bodrov, Yong Kim, Yannis Kalaidzidis, Shabaz Mohammed
Publikováno v:
Schubert, S, Knoch, K-P, Ouwendijk, J, Mohammed, S, Bodrov, Y, Jäger, M, Altkrüger, A, Wegbrod, C, Adams, M E, Kim, W Y, Froehner, S C, Jensen, O N, Kalaidzidis, Y & Solimena, M 2010, ' β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules ', P L o S One, vol. 5, no. 9, pp. e12929 . https://doi.org/10.1371/journal.pone.0012929
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12929 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12929 (2010)
The molecular basis for the interaction of insulin granules with the cortical cytoskeleton of pancreatic β-cells remains unknown. We have proposed that binding of the granule protein ICA512 to the PDZ domain of β2-syntrophin anchors granules to act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d91c2064d658f8090628cec99fd18e
https://portal.findresearcher.sdu.dk/da/publications/03a0bfd3-03cc-41ac-aab1-067701a8ec10
https://portal.findresearcher.sdu.dk/da/publications/03a0bfd3-03cc-41ac-aab1-067701a8ec10
Autor:
Hassan Mziaut, Sandra Schubert, Mirko Trajkovski, Michele Solimena, Anke Altkrüger, Yannis Kalaidzidis
Publikováno v:
The Journal of biological chemistry, Vol. 283, No 48 (2008) pp. 33719-33729
Insulin maintains homeostasis of glucose by promoting its uptake into cells from the blood. Hyperglycemia triggers secretion of insulin from pancreatic β-cells. This process is mediated by secretory granule exocytosis. However, how β-cells keep gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566e17dc215e5c92a75d67b14719aed9
https://europepmc.org/articles/PMC2662281/
https://europepmc.org/articles/PMC2662281/
Autor:
Michele Solimena, Anke Altkrüger, Hassan Mziaut, Mirko Trajkovski, Myung-Shik Lee, Darja Schmidt, Armin Ehninger, Regis P. Lemaitre, Stephan Kersting, Hans-Detlev Saeger, David N. Drechsel, Stefan Müller
Publikováno v:
Nature cell biology, Vol. 8, No 5 (2006) pp. 435-445
Nutrients and growth hormones promote insulin production and the proliferation of pancreatic beta-cells. An imbalance between ever-increasing metabolic demands and insulin output causes diabetes. Recent evidence indicates that beta-cells enhance insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4ebc18709347114bcdedc37e623714
https://pubmed.ncbi.nlm.nih.gov/16622421
https://pubmed.ncbi.nlm.nih.gov/16622421
Autor:
Michele Solimena, Hassan Mziaut, Stefan Müller, Klaus-Peter Knoch, Anke Altkrüger, Joke Ouwendijk, Mirko Trajkovski
Publikováno v:
The Journal of Cell Biology
The journal of cell biology, Vol. 167, No 6 (2004) pp. 1063-1074
The journal of cell biology, Vol. 167, No 6 (2004) pp. 1063-1074
Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic β-cells. Here, we show that exocytosis of SGs and insertion of ICA512 in the plasma membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86391b24645dfa859d6076b1aa4b3a9c
https://pubmed.ncbi.nlm.nih.gov/15596545
https://pubmed.ncbi.nlm.nih.gov/15596545