HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status.

Autor: Leblond AL; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Helmchen B; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Ankavay M; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lenggenhager D; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Jetzer J; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Helmchen F; Brain Research Institute, University of Zurich, Zurich, Switzerland., Yurtsever H; Institute of Pathology, Cantonal Hospital, Aarau, Switzerland., Parrotta R; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Healy ME; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Pöschel A; Institute of Veterinary Pharmacology and Toxicology, University of Zurich - Vetsuisse Faculty, Zürich, Switzerland., Markkanen E; Institute of Veterinary Pharmacology and Toxicology, University of Zurich - Vetsuisse Faculty, Zürich, Switzerland., Semmo N; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Ferrié M; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France., Cocquerel L; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, France., Seeger H; Clinic of Nephrology, University Hospital Zurich, Zurich, Switzerland., Hopfer H; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Müllhaupt B; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland., Gouttenoire J; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Moradpour D; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Gaspert A; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland., Weber A; Department of Pathology and Molecular Pathology, University of Zurich (UZH) and University Hospital Zurich (USZ), Zurich, Switzerland. achim.weber@usz.ch.; Institute of Molecular Cancer Research (IMCR), University of Zurich (UZH), Zurich, Switzerland. achim.weber@usz.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 14; Vol. 15 (1), pp. 8849. Date of Electronic Publication: 2024 Oct 14.

The endocytic recycling compartment serves as a viral factory for hepatitis E virus.

Autor: Bentaleb C; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Hervouet K; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Montpellier C; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Camuzet C; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Ferrié M; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Burlaud-Gaillard J; Inserm U1259, Morphogénèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours and CHRU de Tours, 37032, Tours, France.; Université de Tours et CHRU de Tours, Plateforme IBiSA de Microscopie Electronique, Tours, France., Bressanelli S; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-Sur-Yvette, France., Metzger K; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Werkmeister E; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR2014-US41-PLBS-Plateformes Lilloises de Biologie and Santé, Lille, France., Ankavay M; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France.; Division of Gastroenterology and Hepatology, Institute of Microbiology, Lausanne, Switzerland., Janampa NL; Inserm U1259, Morphogénèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours and CHRU de Tours, 37032, Tours, France., Marlet J; Inserm U1259, Morphogénèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours and CHRU de Tours, 37032, Tours, France., Roux J; BIOTEM, Apprieu, France., Deffaud C; BIOTEM, Apprieu, France., Goffard A; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Rouillé Y; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Dubuisson J; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Roingeard P; Inserm U1259, Morphogénèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours and CHRU de Tours, 37032, Tours, France.; Université de Tours et CHRU de Tours, Plateforme IBiSA de Microscopie Electronique, Tours, France., Aliouat-Denis CM; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France., Cocquerel L; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France. laurence.cocquerel@cnrs.fr.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Dec 03; Vol. 79 (12), pp. 615. Date of Electronic Publication: 2022 Dec 03.

Expanding the Hepatitis E Virus Toolbox: Selectable Replicons and Recombinant Reporter Genomes.

Autor: Oechslin N; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland., Ankavay M; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland., Moradpour D; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland., Gouttenoire J; Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Publikováno v: Viruses [Viruses] 2023 Mar 28; Vol. 15 (4). Date of Electronic Publication: 2023 Mar 28.

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.

Autor: Crouchet E; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Bandiera S; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Fujiwara N; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li S; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., El Saghire H; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Fernández-Vaquero M; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Riedl T; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Sun X; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hirschfield H; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Jühling F; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Zhu S; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Roehlen N; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Ponsolles C; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Heydmann L; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Saviano A; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France.; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France., Qian T; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Venkatesh A; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Lupberger J; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Verrier ER; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Sojoodi M; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Oudot MA; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Duong FHT; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France.; Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland., Masia R; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Wei L; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Thumann C; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Durand SC; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., González-Motos V; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Heide D; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany., Hetzer J; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany., Nakagawa S; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ono A; Department of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan., Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Higashi T; Department of Gastroenterological Surgery, Kumamoto University, Kumamoto, Japan., Sanchez R; Department of Pharmacological Sciences and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kim RS; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Bian CB; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kiani K; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Croonenborghs T; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; KU Leuven Technology Campus Geel, AdvISe, Geel, Belgium., Subramanian A; Department of Neurology, Harvard Medical School, Boston, MA, USA., Chung RT; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Straub BK; Institute of Pathology, University Medicine, Johannes Gutenberg University, Mainz, Germany., Schuppan D; Institute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Ankavay M; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of Lille, Lille, France., Cocquerel L; University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of Lille, Lille, France., Schaeffer E; CNRS UPR3572 Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France., Goossens N; Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland., Koh AP; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Mahajan M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Gunasekaran G; Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Schwartz ME; Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Bardeesy N; Massachusetts General Hospital Cancer Center; Harvard Medical School, Cambridge St. CPZN 4216, Boston, MA, USA., Shalek AK; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Medical Engineering Science & Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Rozenblatt-Rosen O; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Genentech, 1 DNA Way, South San Francisco, CA, USA., Regev A; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Genentech, 1 DNA Way, South San Francisco, CA, USA., Felli E; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France.; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France., Pessaux P; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France.; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France., Tanabe KK; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Heikenwälder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany., Schuster C; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France., Pochet N; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Zeisel MB; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.; Université de Strasbourg, Strasbourg, France.; Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), Lyon, France., Fuchs BC; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Bryan.Fuchs@ferring.com.; Ferring Pharmaceuticals Inc 4245 Sorrento Valley Blvd, San Diego, CA, USA. Bryan.Fuchs@ferring.com., Hoshida Y; Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Yujin.Hoshida@UTSouthwestern.edu., Baumert TF; Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France. thomas.baumert@unistra.fr.; Université de Strasbourg, Strasbourg, France. thomas.baumert@unistra.fr.; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France. thomas.baumert@unistra.fr.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 17; Vol. 12 (1), pp. 5525. Date of Electronic Publication: 2021 Sep 17.

A Useful Method to Provide Infectious and Cultivable In Vitro Naked Viral Particles of Hepatitis A Virus.

Autor: Verbrugghe, Gwenaëlle^1,2 (AUTHOR) audrey.fraisse@anses.fr, Soudan-Foulques, Chloé³ (AUTHOR) chloe.soudan@vet-alfort.fr, Fraisse, Audrey² (AUTHOR) sylvie.perelle@anses.fr, Waldman Vigne, Prunelle² (AUTHOR), Perelle, Sylvie² (AUTHOR), Ndoye, Fatou-Toutie¹ (AUTHOR), Martin-Latil, Sandra^2,3 (AUTHOR) gwenaelle.verbrugghe@inrae.fr

Publikováno v: Viruses (1999-4915). Sep2024, Vol. 16 Issue 9, p1360. 10p.