Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anjuli M. Timmer"'
Autor:
Satoshi Uchiyama, Simon Döhrmann, Anjuli M. Timmer, Neha Dixit, Mariam Ghochani, Tamara Bhandari, John C. Timmer, Kimberly Sprague, Juliane Bubeck Wardenburg, Scott I Simon, Victor Nizet
Publikováno v:
Frontiers in Immunology, Vol 6 (2016)
Group A Streptococcus (GAS) causes a wide range of human infections, ranging from simple pharyngitis to life-threatening necrotizing fasciitis and toxic shock syndrome. A globally disseminated clone of M1T1 GAS has been associated with an increase in
Externí odkaz:
https://doaj.org/article/c0756b9e7cbe4c2daeddd760337a4097
Autor:
Laura E Crotty Alexander, Brenda J Marsh, Anjuli M Timmer, Ann E Lin, Kayvan Zainabadi, Agnieszka Czopik, Leonard Guarente, Victor Nizet
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84481 (2013)
The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being investigated as therapeutic agen
Externí odkaz:
https://doaj.org/article/0befb1217f794ca68c249b6b2167070b
Autor:
John C. Timmer, Mariam Ghochani, Juliane Bubeck-Wardenburg, Simon Döhrmann, Anjuli M. Timmer, Tamara Bhandari, Neha Dixit, Kimberly Sprague, Satoshi Uchiyama, Victor Nizet, Scott I. Simon
Publikováno v:
Frontiers in Immunology, Vol 6 (2016)
Frontiers in Immunology
Frontiers in Immunology
Group A Streptococcus (GAS) causes a wide range of human infections, ranging from simple pharyngitis to life-threatening necrotizing fasciitis and toxic shock syndrome. A globally disseminated clone of M1T1 GAS has been associated with an increase in
Autor:
Anjuli M. Timmer, Sameera Bilgrami, Syed Raza Ali, Eek Joong Park, Victor Nizet, Michael Karin, Lars Eckmann
Publikováno v:
Immunity. 35:34-44
SummaryDetection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to activation of protective host responses. However, it is still unclear how immune cells speci
Autor:
Maren von Köckritz-Blickwede, Victor Nizet, Anjuli M. Timmer, Richard L. Gallo, Suzan H.M. Rooijakkers, Laura E. Crotty Alexander, Heather C. Maisey
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Crotty Alexander, Laura E.; Maisey, Heather C.; Timmer, Anjuli M.; Rooijakkers, Suzan H.; Gallo, Richard L.; Köckritz-Blickwede, Maren; et al.(2010). M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. Journal of Molecular Medicine, 88(4), pp 371-381. doi: 10.1007/s00109-009-0566-9. Retrieved from: http://www.escholarship.org/uc/item/5j21w18f
Crotty Alexander, Laura E.; Maisey, Heather C.; Timmer, Anjuli M.; Rooijakkers, Suzan H.; Gallo, Richard L.; Köckritz-Blickwede, Maren; et al.(2010). M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. Journal of Molecular Medicine, 88(4), pp 371-381. doi: 10.1007/s00109-009-0566-9. Retrieved from: http://www.escholarship.org/uc/item/5j21w18f
Group A Streptococcus is a leading human pathogen associated with a diverse array of mucosal and systemic infections. Cell wall anchored pili were recently described in several species of pathogenic streptococci, and in the case of GAS, these surface
Autor:
John C. Timmer, Anjuli M. Timmer, Morgan A. Pence, Mariam Ghochani, Victor Nizet, Terrence G. Frey, Michael Karin, Li-Chung Hsu, Guy S. Salvesen
Publikováno v:
Journal of Biological Chemistry. 284:862-871
Group A Streptococcus (GAS) is a leading human bacterial pathogen capable of producing invasive infections even in previously healthy individuals. As frontline components of host innate defense, macrophages play a key role in control and clearance of
Autor:
Victor Nizet, John T. Buchanan, Mike R. Vicknair, Silpa K. Patel, Anjuli M. Timmer, Kelly M. Colvin
Publikováno v:
Veterinary Microbiology. 131:145-153
Streptococcus iniae is a major fish pathogen producing invasive infections that result in economic losses in aquaculture. Development of in vitro models of S. iniae virulence may provide insight to the pathogenesis of infection invivo. Three S. iniae
Autor:
Victor Nizet, Shiranee Sriskandan, Emanuel Hanski, Claire E. Turner, Anjuli M. Timmer, Jeffrey B. Locke, Inbal Mishalian, Annelies S. Zinkernagel, John T. Buchanan, Morgan A. Pence
Publikováno v:
Cell Host & Microbe. 4(2):170-178
SummaryInterleukin-8 (IL-8) promotes neutrophil-mediated host defense through its chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS) protease SpyCEP (also called ScpC) cleaves IL-8, and SpyCEP expression is strongly upr
Autor:
Victor Nizet, Anjuli M. Timmer
Publikováno v:
The Journal of Experimental Medicine
The nuclear factor κB (NF-κB) pathway plays a central role in inflammation and immunity. In response to proinflammatory cytokines and pathogen-associated molecular patterns, NF-κB activation is controlled by IκB kinase (IKK)β. Using Cre/lox-medi
Autor:
Victor Nizet, Arya Khosravi, Kelly S. Doran, Laura A. Kwinn, Ramy K. Aziz, Malak Kotb, Anjuli M. Timmer
Publikováno v:
Journal of Bacteriology. 189:1322-1329
Group A Streptococcus (GAS) is a leading human pathogen associated with a wide spectrum of mucosal and invasive infections. GAS expresses a large number of virulence determinants whose expression is under the control of several transcriptional regula