A new FRDA mouse model [ Fxn ^null :YG8s(GAA) > 800] with more than 800 GAA repeats.

Autor: Kalef-Ezra E; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Edzeamey FJ; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Valle A; Energy Metabolism and Nutrition, Research Institute of Health Sciences (IUNICS), University of Balearic Islands, Palma, Spain.; Health Research Institute of Balearic Islands (IdISBa), Palma, Spain.; Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBERobn CB06/03/0043), Instituto de Salud Carlos III, Madrid, Spain., Khonsari H; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Kleine P; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Oggianu C; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Al-Mahdawi S; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Pook MA; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom., Anjomani Virmouni S; Ataxia Research Group, Division of Biosciences, Department of Life Sciences, Brunel University London, Uxbridge, United Kingdom.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2023 Jan 26; Vol. 17, pp. 930422. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).

Genotype and Phenotype Characterisation of an Enhanced Friedreich Ataxia GAA Repeat Expansion Mouse Model Fxn_null::YG8s(GAA)>800

Autor: Anjomani-Virmouni, S, Kalef-Ezra, E, Valle, A, Kleine, P, Oggianu, C, Hannana, T, Al-Mahdawi, S, Pook, M

Publikováno v: IARC International Ataxia Research Conference

Our lab has previously generated YG8R and YG22R FRDA mouse models that are based upon human FXNYAC transgenic mice containing a large FXNhuman genomic transgene with GAA repeat expansions crossed with Fxn- knockout mice. These mouse models have exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a69d81360bbb8bd8354c30018fac7ffc
http://bura.brunel.ac.uk/handle/2438/19757

PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN

Autor: Gupta, A, Anjomani-Virmouni, S, Koundouros, N, Poulogiannis, G

Publikováno v: Molecular & Cellular Oncology

Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss of parkin RBR E3 ubiquitin pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e848e12bdbf596ae5cc665e2d4e8db3f
http://europepmc.org/articles/PMC5706935

The evolution of S-nitrosylation detection methodology and the role of protein S-nitrosylation in various cancers.

Autor: Liang, Feng¹ (AUTHOR), Wang, Min¹ (AUTHOR), Li, Jiannan¹ (AUTHOR), Guo, Jie² (AUTHOR) guojie@jlu.edu.cn

Publikováno v: Cancer Cell International. 12/19/2024, Vol. 24 Issue 1, p1-22. 22p.

Identification of telomere dysfunction in Friedreich ataxia

Autor: Anjomani-Virmouni, S, Al-Mahdawi, S, Sandi, C, Yasaei, H, Slijepcevic, P, Pook, M

Publikováno v: EMBO Conference on Telomeres, Telomerase and Disease

In Friedreich ataxia (FRDA), GAA repeat expansion within the first intron of the frataxin (FXN) gene leads to downregulation of FXN, resulting in oxidative stress, mitochondrial iron accumulation and neuronal atrophy. We hypothesised that telomere le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______900::9ae9bd6d7a666cf54f5dfe95456e9cc3
https://bura.brunel.ac.uk/handle/2438/10224