Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anjeza Pashaj"'
Publikováno v:
Journal of Biological Chemistry. 290:26476-26490
Adaptive thermogenesis is the cellular process transforming chemical energy into heat in response to cold. A decrease in adaptive thermogenesis is a contributing factor to obesity. However, the molecular mechanisms responsible for the compromised ada
Autor:
Timothy P. Carr, Neetu Sud, Yongyan Song, Miaoyun Zhao, Anjeza Pashaj, Qiaozhu Su, Patricia Christian, Jing Shen, Hai Wang, Kezhong Zhang
Publikováno v:
Scientific Reports
Wang, H, Zhao, M, Sud, N, Christian, P, Shen, J, Song, Y, Pashaj, A, Zhang, K, Carr, T & Su, Q 2016, ' Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis ', Scientific Reports, vol. 6, pp. 1-11 . https://doi.org/10.1038/srep32246
Wang, H, Zhao, M, Sud, N, Christian, P, Shen, J, Song, Y, Pashaj, A, Zhang, K, Carr, T & Su, Q 2016, ' Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis ', Scientific Reports, vol. 6, pp. 1-11 . https://doi.org/10.1038/srep32246
Insulin induced gene-2 (Insig-2) is an ER-resident protein that inhibits the activation of sterol regulatory element-binding proteins (SREBPs). However, cellular factors that regulate Insig-2 expression have not yet been identified. Here we reported
Publikováno v:
Canadian journal of physiology and pharmacology. 93(12)
Considering the current obesity epidemic in the United States (>100 million adults are overweight or obese), the prevalence of hypertriglyceridemia is likely to grow beyond present statistics of ∼30% of the population. Conventional therapies for ma
Autor:
Lawrence G. Harshman, James D. Eudy, Fang Yu, Chi Zhang, Anjeza Pashaj, Kylee Gardner, Kimberly A. Carlson, Darby J. Carlson
Publikováno v:
Genetics Research International
Genetics Research International, Vol 2015 (2015)
Genetics Research International, Vol 2015 (2015)
Aging is a complex process characterized by a steady decline in an organism’s ability to perform life-sustaining tasks. In the present study, two cages of approximately 12,000 mated Drosophila melanogaster females were used as a source of RNA from
Publikováno v:
The FASEB Journal. 29
Recombinant FGF21 (rFGF21) is an experimental polypeptide therapy against type-2 diabetes and lipid anomalies. However, the high costs of producing rFGF21 and the mode of delivery by injection are ...
Publikováno v:
The FASEB Journal. 28
The pleiotropic hormone-like polypeptide, fibroblast growth factor 21 (FGF21), is a major modulator of lipid and glucose metabolism and an exploratory treatment strategy for obesity related metabolic disorders. Recombinant FGF21 (rFGF21) is currently
Publikováno v:
Fly. 2:149-151
Drosophila melanogaster is an ideal model organism for various types of aging studies. They are easy to maintain, relatively inexpensive, have short life cycles, provide large sample sizes, and can be genetically manipulated via various methods for t
Publikováno v:
Physiological genomics. 45(23)
We report on the characterization of lipogenic tissue transcriptional networks that support physiological responses of obese rats to a lipid-lowering bioactive food compound, R-α-lipoic acid (LA). Nine-week-old male Zucker diabetic fatty (fa/fa) rat
Publikováno v:
Biochemical and biophysical research communications. 439(3)
Controlling elevated blood triacylglycerol translates into substantial health benefits. The present study aimed to evaluate the triacylglycerol-lowering properties of (R)-α-lipoic acid (LA) once circulating triacylglycerol levels have become elevate
Publikováno v:
The FASEB Journal. 27