In vitro production of naked mole-rats’ blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection

Autor: Raffaella Simone, Daniel Čižmár, Susanne Holtze, Geert Michel, Anje Sporbert, Charlotte Okolo, Thomas B. Hildebrandt

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract The African naked mole-rat (Heterocephalus glaber) is an attractive model for cancer and aging research due to its peculiar biological traits, such as unusual long life span and resistance to cancer. The establishment of induced pluripotent

Externí odkaz: https://doaj.org/article/8f8602e315804c4f8ab18faf6a286666

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

Autor: Adam Myszczyszyn, Oliver Popp, Severine Kunz, Anje Sporbert, Simone Jung, Louis C. Penning, Annika Fendler, Philipp Mertins, Walter Birchmeier

Publikováno v: PLoS ONE, Vol 19, Iss 3 (2024)

Externí odkaz: https://doaj.org/article/45df5d4b3c334d8c8c244cadd07071d1

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

Autor: Angela Schulz, Nicola Victoria Müller, Nina Anne van de Lest, Andreas Eisenreich, Martina Schmidbauer, Andrei Barysenka, Bettina Purfürst, Anje Sporbert, Theodor Lorenzen, Alexander M Meyer, Laura Herlan, Anika Witten, Frank Rühle, Weibin Zhou, Emile de Heer, Marion Scharpfenecker, Daniela Panáková, Monika Stoll, Reinhold Kreutz

Publikováno v: eLife, Vol 8 (2019)

Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminur

Externí odkaz: https://doaj.org/article/3ce65e8761e146108e0f630955c54002

IFNγ binding to extracellular matrix prevents fatal systemic toxicity

Autor: Josephine Kemna, Evelyne Gout, Leon Daniau, Jessica Lao, Kristoffer Weißert, Sandra Ammann, Ralf Kühn, Matthias Richter, Christine Molenda, Anje Sporbert, Dario Zocholl, Robert Klopfleisch, Hugues Lortat-Jacob, Peter Aichele, Thomas Kammertoens, Thomas Blankenstein

Publikováno v: Nature Immunology
Nature Immunology, 2023, ⟨10.1038/s41590-023-01420-5⟩
Nature Immunology, 2023, 24 (3), pp.414-422. ⟨10.1038/s41590-023-01420-5⟩

Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor (IFNγR) and to extracellular matrix (ECM) via four positively cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2795f36be82eab84f706e12f7f7bb4
http://edoc.mdc-berlin.de/23037/1/23037oa.pdf

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation

Autor: Ahmet Bugra Tufan, Katina Lazarow, Marina Kolesnichenko, Anje Sporbert, Jens Peter von Kries, Claus Scheidereit

SUMMARYIn a genome-wide screening for components of the dsDNA-break-induced IKK-NF-κB pathway we identified scores of regulators, including tumor susceptibility protein TSG101. TSG101 is essential for DNA damage-induced formation of cellular poly(AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b28615c4b4e967f73c3970d2df10932
http://edoc.mdc-berlin.de/22119/1/22119oa.pdf