The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects

Autor: Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

SWR-C and its substrate the histone variant Htz1 are considered important for genome maintenance. Here the authors reveal that SWR-C/Htz1 plays a critical role during replication stress caused by absence of the replication fork progression proteins M

Externí odkaz: https://doaj.org/article/26b3c91b973843c4a9d010d3be601fc1

Cdc73 suppresses genome instability by mediating telomere homeostasis.

Autor: Rahul V Nene, Christopher D Putnam, Bin-Zhong Li, Katarina G Nguyen, Anjana Srivatsan, Christopher S Campbell, Arshad Desai, Richard D Kolodner

Publikováno v: PLoS Genetics, Vol 14, Iss 1, p e1007170 (2018)

Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with

Externí odkaz: https://doaj.org/article/e10b794a7beb46f09ac5db8e7a0c1cc8

Co-orientation of replication and transcription preserves genome integrity.

Autor: Anjana Srivatsan, Ashley Tehranchi, David M MacAlpine, Jue D Wang

Publikováno v: PLoS Genetics, Vol 6, Iss 1, p e1000810 (2010)

In many bacteria, there is a genome-wide bias towards co-orientation of replication and transcription, with essential and/or highly-expressed genes further enriched co-directionally. We previously found that reversing this bias in the bacterium Bacil

Externí odkaz: https://doaj.org/article/cf5890a7927e44ea96d13eb07953cda3

Abstract 1628: A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects

Autor: Yanhua Rao, Anjana Srivatsan, Marya Liimatta, Diana Munoz, Jeanne Quirit, Jianxia Shi, An Nguyen, Xin Linghu, Federowicz Federowicz, Brian Jones, Melissa Fleury, Zach Newby, Michael P. Dillon, Paul A. Barsanti, Mark R. Lackner, Michael A. White, Yang Lee, Phil Landis, Yang Peng, Michelle Cicchini, Josh Cottom, Leng Nickels, Ed Brnardic, Michael DeMartino, Josh Taygerly

Publikováno v: Cancer Research. 83:1628-1628

Werner syndrome protein (WRN) is a RecQ-family helicase involved in the maintenance of genome integrity. Germline mutations in WRN cause premature aging and cancer predisposition. Analysis of systematic RNAi and CRISPR screening data has previously r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15196273d127bc0ec3c0b9c164a7c0c9
https://doi.org/10.1158/1538-7445.am2023-1628

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

Autor: Elaine Guo, Christopher D. Putnam, Timothy C. Gahman, Yuki Ishii, James L. Mueller, Jean Y. J. Wang, Richard D. Kolodner, Anjana Srivatsan

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 32

Significance Analysis of synthetic lethal relationships identified in Saccharomyces cerevisiae was used to identify candidate therapeutic targets for cancers with BRCA1 or BRCA2 defects. Inhibition of one of these targets, flap endonuclease 1 (FEN1),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24f3e7d46beaa59510638a581fb0da0
https://pubmed.ncbi.nlm.nih.gov/32817488