The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy

Autor: Andrew R. Tee, Pavandeep K. Rai, Douglass M. Turnbull, Mohd Shazli Draman, Colin M. Dayan, Lei Zhang, Marian Ludgate, D. Aled Rees, Satomi Miwa, Daniel S Morris, Anjana S Haridas

Context Depot-specific expansion of orbital adipose tissue (OAT) in Graves orbitopathy (GO; an autoimmune condition producing proptosis, visual impairment and reduced quality of life) is associated with fatty acid (FA)-uptake–driven adipogenesis in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d17d1ca9f92e5bf145d5296d378ec8

Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy

Autor: Amy E. Vincent, Christopher John Von Ruhland, Andrew R. Tee, Sarah Edkins, D. Aled Rees, Lei Zhang, Fredrik Karpe, Rolando Berlinguer-Palmini, Mohd Shazli Draman, Colin M. Dayan, Marian Ludgate, Douglass M. Turnbull, Anna Evans, Daniel S Morris, Anjana S Haridas

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9145, p 9145 (2020)

Depot specific expansion of orbital-adipose-tissue (OAT) in Graves&rsquo
Orbitopathy (GO) is associated with lipid metabolism signaling defects. We hypothesize that the unique adipocyte biology of OAT facilitates its expansion in GO. A comprehen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58be9c7061ebcc2789072e93168802f3
https://orca.cardiff.ac.uk/id/eprint/136757/1/ijms-21-09145-v2.pdf

Prostaglandin F2-Alpha Eye Drops (Bimatoprost) in Graves' Orbitopathy: A Randomized Controlled Double-Masked Crossover Trial (BIMA Trial)

Autor: Rosemary Greenwood, Lei Zhang, Chris Foy, Ilaria Muller, Julie Pell, Daniel S Morris, Sam G. Evans, Anjana S Haridas, Mohd Shazli Draman, Colin M. Dayan, Pakinee Pooprasert, Carol M. Lane, Onyebuchi E. Okosieme, Peter N. Taylor, Marian Ludgate

Publikováno v: Draman, M S, Morris, D S, Evans, S, Haridas, A, Pell, J, Greenwood, R, Foy, C, Taylor, P, Pooprasert, P, Muller, I, Zhang, L, Lane, C, Okosieme, O, Ludgate, M & Dayan, C 2019, ' Prostaglandin F2-Alpha Eye Drops (Bimatoprost) in Graves' Orbitopathy : A Randomized Controlled Double-Masked Crossover Trial (BIMA Trial) ', Thyroid, vol. 29, no. 4, pp. 563-572 . https://doi.org/10.1089/thy.2018.0506

Background: Previous in vitro experiments have demonstrated that prostaglandin F2-alpha (PF 2α ) reduced proliferation and adipogenesis in a murine cell line and human orbital fibroblasts derived from subjects with inactive Graves' orbitopathy (GO).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda64f7c267a3ada346fad08214a9a95
https://pubmed.ncbi.nlm.nih.gov/30880626

Prolonged mydriasis after inadvertent topical administration of the calcium channel antagonist amlodipine: implications for glaucoma drug development

Autor: Anjana S. Haridas, Jonathan C. P. Roos

Publikováno v: Cutaneous and Ocular Toxicology. 34:84-87

Calcium channel inhibitors are being investigated as potential therapeutic adjuncts to reduce painful ciliary muscle spasm and control intraocular pressure in glaucoma. Relatively little is known about the effect of topical administration of calcium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356247a52620f836605ce353f7d854ab
https://doi.org/10.3109/15569527.2014.896016

Periocular necrotising fasciitis: a multicentre case series

Autor: Khami Satchi, Anjana S. Haridas, Cornelius Rene, Dinesh Selva, Jimmy Uddin, Saul N. Rajak, Geoffrey E. Rose, Alan A McNab, Timothy J. Sullivan, Edwin C. Figueira

Publikováno v: The British journal of ophthalmology. 100(11)

Introduction Necrotising fasciitis (NF) is a severe infection of deep subcutaneous soft tissues with high morbidity and mortality. Periocular necrotising fasciitis (PONF) is a very rare condition with many unanswered questions about the presentation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce101e279d1bc8fe489d5e01a7cd78eb
https://pubmed.ncbi.nlm.nih.gov/26837505