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Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells

Autor: Hugo Sanchez-Ruderisch, Anja Rabien, Katharina Detjen, Noreen Otto, Bertram Wiedenmann, Petra Schulz, Anja Wimmel

Publikováno v: Cancer Science. 103:169-175

Pancreatic cancer is characterized by oncogenic activation of K-Ras and inactivation of the cell cycle inhibitor p16INK4a. We previously demonstrated that reintroduction of p16INK4a reversed anoikis resistance and clonogenicity of human pancreatic ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06724123873e5eac760bbd6981446c28
https://doi.org/10.1111/j.1349-7006.2011.02140.x

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Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

Autor: Katharina Detjen, Sabine André, Christian Fischer, Anja Wimmel, Hugo Sanchez-Ruderisch, M. Welzel, Hans-Joachim Gabius, Joachim C. Manning

Publikováno v: FEBS Journal. 277:3552-3563

The tumor suppressor p16INK4a has functions beyond cell-cycle control via cyclin-dependent kinases. A coordinated remodeling of N- and O-glycosylation, and an increase in the presentation of the endogenous lectin galectin-1 sensing these changes on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac48e03ab3a06379cc1f7985e72a5ba
https://doi.org/10.1111/j.1742-4658.2010.07764.x

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Autocrine growth inhibition by transforming growth factor -1 (TGF -1) in human neuroendocrine tumour cells

Autor: Anja Wimmel, Stefan Rosewicz, Bertram Wiedenmann

Publikováno v: Gut. 52:1308-1316

Background and aim: The role of transforming growth factor β-1 (TGFβ-1) in neuroendocrine tumour biology is currently unknown. We therefore examined the expression and biological significance of TGFβ signalling components in neuroendocrine tumours

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdd2c8ae9f5b7c28a791ba5f894414ee
https://doi.org/10.1136/gut.52.9.1308

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Variant expression of CD44 in preneoplastic lesions of the lung

Autor: Marcus Schuermann, Evguenia Kogan, Annette Ramaswamy, Anja Wimmel

Publikováno v: Cancer. 92:1231-1236

BACKGROUND Specific CD44 isoforms are cell surface adhesion molecules and have been shown to be associated with tumor progression and metastasis. In lung carcinoma, CD44 expression has been reported to be a feature of nonsmall cell lung carcinoma (NS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e93d582be8877ecef88bef2fbc66e6d
https://doi.org/10.1002/1097-0142(20010901)92:5<1231::aid-cncr1442>3.0.co

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Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesion

Autor: Alison Kraus, Anja Wimmel, D. Glitz, J Roeder, Marcus Schuermann

Publikováno v: European Journal of Cancer. 37:2264-2274

Axl is a receptor tyrosine kinase (RTK) with oncogenic potential and transforming activity. Since Axl bears structural similarities to cell adhesion molecules such as neural cell adhesion molecule (NCAM) (FNIII domains), it is thought that Axl might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa482caf2adb9da6b16cfdb52d402cfb
https://doi.org/10.1016/s0959-8049(01)00271-4

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Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

Autor: Hugo, Sanchez-Ruderisch, Christian, Fischer, Katharina M, Detjen, Martina, Welzel, Anja, Wimmel, Joachim C, Manning, Sabine, André, Hans-Joachim, Gabius

Publikováno v: The FEBS journal. 277(17)

The tumor suppressor p16(INK4a) has functions beyond cell-cycle control via cyclin-dependent kinases. A coordinated remodeling of N- and O-glycosylation, and an increase in the presentation of the endogenous lectin galectin-1 sensing these changes on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::203b4c235751461015a07f66b8ac9b84
https://pubmed.ncbi.nlm.nih.gov/20695889

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In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways

Autor: Guntram Suske, Ines Ferber, Juergen Schlegel, Hannah Specht, Markus W. Gross, Marcus Schuermann, Alison Kraus, Anja Wimmel, Sven-Oliver Bachmann

Publikováno v: Oncogene. 21(57)

Most small cell lung cancer (SCLC) patients relapse within 12 months of starting combination chemotherapy plus radio-therapy, due to the development of acquired chemo- and radio-resistance. This phenomenon relates to the induction of tumour different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee54d7e3522d53a894b9ce4b6c27a484
https://pubmed.ncbi.nlm.nih.gov/12483521

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Transition from suspension to adherent growth is accompanied by tissue factor expression and matrix metalloproteinase secretion in a small cell lung cancer cell line

Autor: Rainer Seitz, Eliane Daubner, Ursula Salge, Marcus Schuermann, Margarethe Heiden, Anja Wimmel

Publikováno v: Journal of cancer research and clinical oncology. 127(2)

Small cell lung cancer (SCLC) is a very malignant tumor known to grow aggressively and to metastasize early. It is well established that metastasis generally involves both tumor cell adhesion and proteolytic degradation of the extracellular matrix. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321695d3b4409575645abbd74e0e507d
https://pubmed.ncbi.nlm.nih.gov/11216916

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