Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anja Wellner"'
Autor:
Gerhard Rubner, Kerstin Bensdorf, Brigitte Kircher, Ronald Gust, Anja Wellner, Silke Bergemann, Ingo Ott
Publikováno v:
Journal of Medicinal Chemistry. 53:6889-6898
[(μ(4)-η(2))-(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), a derivative of aspirin (ASS), demonstrated high growth-inhibitory potential against various tumor cells with interference in the arachidonic acid cascade as probable mode
Autor:
Christa E. Müller, Anke C. Schiedel, Sandra Dettmann, Ronald Gust, Katrin Szymanowitz, Anja Wellner
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:4905-4916
2-Phenyl-1H-benzimidazoles 7a–e were synthesized and tested for gene activation on ERα-positive MCF-7 breast cancer cells, stably transfected with the reporter plasmid EREwtcluc (MCF-7-2a cells). None of the compounds showed agonistic properties,
Autor:
Michael Zielzki, Anja Wellner, Fiona Mackay, Renate Grünert, Patrick J. Bednarski, Peter J. Sadler
Publikováno v:
Chemistry & Biology. 13(1):61-67
SummaryA possible way to avoid dose-limiting side effects of platinum anticancer drugs is to employ light to cause photochemical changes in nontoxic platinum prodrugs that release active antitumor agents. This strategy could be used in the treatment
Publikováno v:
Journal of medicinal chemistry. 55(22)
In continuation of our previous work, several 1-alkyl-2,3,5-tris(4-hydroxyphenyl)aryl-1H-pyrroles with chlorine or fluorine substituents in the aryl residues were synthesized and tested for estrogen receptor (ER) binding at isolated ERα/ERβ recepto
Autor:
Marcus Weber, Alexander Bujotzek, Ronald Gust, Min Shan, Anja Wellner, Oliver Seitz, Frank Abendroth, Rainer Haag
Publikováno v:
Chembiochem : a European journal of chemical biology. 12(17)
The estrogen receptor binding affinities of bivalent raloxifene ligands tethered by flexible spacers of different lengths have been evaluated in vitro. Two bivalent binding modes, intra- and intermolecular, were hypothesized to explain their differen
Publikováno v:
ChemMedChem. 6(11)
1-Alkyl-2,3,5-triaryl-1H-pyrroles (for which alkyl=methyl, ethyl, n-propyl, or 2-methylpropyl) were tested for stability, estrogen receptor (ER) binding, and inhibition of tumor cell growth. These pyrroles (type B) showed higher stability in aqueous
Publikováno v:
ChemMedChem. 6(5)
In this study, we synthesized 1,2,4-triarylpyrroles as ligands for the estrogen receptor (ER). Two pyrrole series were prepared with either C3-alkyl or C3/C5-dialkyl residues. Compounds from both series were susceptible to oxidative degradation-dialk
Autor:
Kerstin Bensdorf, Wukun Liu, Xueting Cai, Ronald Gust, Hai Qian, Fan Qi, Huibin Zhang, Anja Wellner, Jinpei Zhou, Zhiyu Li, Wenlong Huang, Peng Cao
Publikováno v:
Archiv der Pharmazie. 344(7)
In an attempt to develop potent and selective anti-tumor drugs, a series of novel 2-amino-thiazole-5-carboxylic acid phenylamide derivatives were designed based on the structure of dasatinib. All compounds were synthesized by a systematic combinatori
Autor:
Jinpei Zhou, Gerhard Rubner, Yanchun Zhang, Haoran Liu, Kerstin Bensdorf, Hai Qian, Can-Cheng Guo, Huibin Zhang, Ronald Gust, Wenlong Huang, Yubin Wang, Wukun Liu, Anja Wellner
Publikováno v:
European journal of medicinal chemistry. 46(3)
A series of C5-substituted licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid) derivatives were developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 ce
Autor:
François Dufrasne, Jean Neve, Ronald Gust, Régis Gasper, Delphine Lamoral-Theys, Robert Kiss, Michel Gelbcke, Gilles Berger, Erik Goormaghtigh, Anja Wellner
Publikováno v:
International journal of oncology. 37(3)
Platinum complexes remain widely used to combat various types of cancers. Three platinum complexes, cisplatin, carboplatin and oxaliplatin, are marketed for various oncological purposes. Additionally, nedaplatin, lobaplatin and heptaplatin have gaine