Development of an infant colon simulating in vitro model, I-TIM-2, to study the effects of modulation strategies on the infant gut microbiome composition and function

Autor: Olivia Colberg, Gerben D. A. Hermes, Tine Rask Licht, Anita Wichmann, Adam Baker, Martin Frederik Laursen, Anja Wellejus

Publikováno v: Microbiology Spectrum, Vol 12, Iss 11 (2024)

ABSTRACT The early life stages are critical for the development of the gut microbiome. Variables such as antibiotics exposure, birth-mode via Cesarean section, and formula feeding are associated with disruptions in microbiome development and are rela

Externí odkaz: https://doaj.org/article/ed0b8be8bbb541db8b8b30a7572cdde7

Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions

Autor: Bastian Seelbinder, Zoltan Lohinai, Ruben Vazquez-Uribe, Sascha Brunke, Xiuqiang Chen, Mohammad Mirhakkak, Silvia Lopez-Escalera, Balazs Dome, Zsolt Megyesfalvi, Judit Berta, Gabriella Galffy, Edit Dulka, Anja Wellejus, Glen J. Weiss, Michael Bauer, Bernhard Hube, Morten O. A. Sommer, Gianni Panagiotou

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Candida species overgrowth in the human gut is considered a prerequisite for invasive candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is still limited. By integrating cross-sectional mycobiome and

Externí odkaz: https://doaj.org/article/995d19354eac486bafefacd3d3f6112b

In Vitro Screening for Probiotic Properties of Lactobacillus and Bifidobacterium Strains in Assays Relevant for Non-Alcoholic Fatty Liver Disease Prevention

Autor: Silvia Lopez-Escalera, Mari L. Lund, Gerben D. A. Hermes, Béatrice S.-Y. Choi, Kei Sakamoto, Anja Wellejus

Publikováno v: Nutrients; Volume 15; Issue 10; Pages: 2361
Lopez-Escalera, S, Lund, M L, Hermes, G D A, Choi, B S Y, Sakamoto, K & Wellejus, A 2023, ' In Vitro Screening for Probiotic Properties of Lactobacillus and Bifidobacterium Strains in Assays Relevant for Non-Alcoholic Fatty Liver Disease Prevention ', Nutrients, vol. 15, no. 10, 2361 . https://doi.org/10.3390/nu15102361

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that poses health challenges worldwide and is expected to continue to rise dramatically. NAFLD is associated with metabolic syndrome, type 2 diabetes mellitus, and impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7edf85888cf81e674e2c253eb8be2d
https://doi.org/10.3390/nu15102361

Bifidobacteriumbreve Bif195 Protects Against Small-Intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers

Autor: Lillian Barry, Clodagh L Murphy, Gafer Elsafi, Johan Van Hylckama Vlieg, Anja Wellejus, Brynjulf Mortensen, Mary Lucey, Adam Baker, Fergus Shanahan, John O’Grady, Henrik Bjørn Nielsen, Vibeke Westphal, Anders Damholt, Oksana Lukjancenko, Aron Charles Eklund, Martin Buckley

Publikováno v: Gastroenterology. 157(3)

Background & Aims Enteropathy and small-intestinal ulcers are common adverse effects of nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid (ASA). Safe, cytoprotective strategies are needed to reduce this risk. Specific bifidobacteria m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c376040a91cc10c6810cb28a734518
https://pubmed.ncbi.nlm.nih.gov/31095949

Synthesis and biological evaluation of Esaprazole analogues showing σ1 binding and neuroprotective properties in vitro

Autor: Anja Wellejus, Heidi Elbrønd-Bek, Morten Sloth Weidner, Signe Humle Jørgensen, Nicholas M. Kelly

Publikováno v: Bioorganic & Medicinal Chemistry. 21:3334-3347

Esaprazole, a molecule previously acknowledged to protect against stomach and intestinal ulcers was surprisingly discovered to have neuroprotective activities and σ1 binding in vitro. A highly diverse set of Esaprazole analogues 2–5 was prepared i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff76177e7541b18955737ddca691f7b5
https://doi.org/10.1016/j.bmc.2013.02.058