Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Anja Weinreich Olsen"'
Autor:
Amber Barton, Ida Rosenkrands, Harry Pickering, Nkoyo Faal, Anna Harte, Hassan Joof, Pateh Makalo, Manon Ragonnet, Anja Weinreich Olsen, Robin L. Bailey, David C. W. Mabey, Frank Follmann, Jes Dietrich, Martin J. Holland
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundOcular infections with Chlamydia trachomatis serovars A–C cause the neglected tropical disease trachoma. As infection does not confer complete immunity, repeated infections are common, leading to long-term sequelae such as scarring and bl
Externí odkaz:
https://doaj.org/article/5664dbac92c84852ae89a535eeb9c6ff
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Ocular and urogenital infections with Chlamydia trachomatis (C.t.) are caused by a range of different serovars. The first C.t. vaccine in clinical development (CTH522/CAF®01) induced neutralizing antibodies directed to the variable domain 4
Externí odkaz:
https://doaj.org/article/6344e9e5dba04b32bbb648fc6b896476
Autor:
Nina Dieu Nhien Tran Nguyen, Safia Guleed, Anja Weinreich Olsen, Frank Follmann, Jan Pravsgaard Christensen, Jes Dietrich
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The requirement for vaccine-induced tissue-resident immunity for protection against one or repeated infections with Chlamydia trachomatis (C.t.) is still not fully resolved. In this study, our aim was to investigate to which degree tissue-resident Th
Externí odkaz:
https://doaj.org/article/078292d308f347e59800f891f7af4924
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/65ecb022852a441aac20933623259b98
Autor:
Karin Erneholm, Emma Lorenzen, Sarah Bøje, Anja Weinreich Olsen, Gregers Jungersen, Henrik E. Jensen, Joseph P. Cassidy, Peter Andersen, Jørgen S. Agerholm, Frank Follmann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The development of a vaccine against genital chlamydia in women is advancing, and the evaluation of in situ immune responses following vaccination and challenge infections is crucial for development of a safe and protective vaccine. This study employ
Externí odkaz:
https://doaj.org/article/5a4e715c72f34d3a9625451cab59fb86
Autor:
Anja Weinreich Olsen, Emma Kathrine Lorenzen, Ida Rosenkrands, Frank Follmann, Peter Andersen
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
There is an unmet need for a vaccine to control Chlamydia trachomatis (C.t.) infections. We have recently designed a multivalent heterologous immuno-repeat 1 (Hirep1) vaccine construct based on major outer membrane protein variable domain (VD) 4 regi
Externí odkaz:
https://doaj.org/article/291f3b2580fc4ec282580eb8258b7d0e
Autor:
Jeanette Erbo Wern, Maria Rathmann Sorensen, Anja Weinreich Olsen, Peter Andersen, Frank Follmann
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The selection of any specific immunization route is critical when defining future vaccine strategies against a genital infection like Chlamydia trachomatis (C.t.). An optimal Chlamydia vaccine needs to elicit mucosal immunity comprising both neutrali
Externí odkaz:
https://doaj.org/article/d2336517e317468b9ed23d777d25ccf0
Autor:
Emma eLorenzen, Frank eFollmann, Sarah eBøje, Karin eErneholm, Anja Weinreich Olsen, Jørgen Steen Agerholm, Gregers eJungersen, Peter eAndersen
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
International efforts in developing a vaccine against Chlamydia trachomatis have highlighted the need for novel immunization strategies for the induction of genital immunity. In this study, we evaluated an intramuscular prime/intranasal boost vaccina
Externí odkaz:
https://doaj.org/article/4db79fc58bdd49e998ae7f6a47fdac3b
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10768 (2010)
BACKGROUND: The chlamydial proteins CT443 (OmcB) and CT521 (rl16) have previously been identified as human B and/or T cell targets during a chlamydial infection in humans. Here we compare the protective effector mechanism promoted by a fusion protein
Externí odkaz:
https://doaj.org/article/85a65878aa84431e9586c6d4226bc884
Autor:
Anja Weinreich Olsen, Emma Lorenzen, Peter Andersen, Jes Dietrich, Malene Hvid, Nina Dieu Nhien Tran Nguyen, Frank Follmann
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)
NPJ Vaccines
Nguyen, N D N T, Olsen, A W, Lorenzen, E, Andersen, P, Hvid, M, Follmann, F & Dietrich, J 2020, ' Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge ', npj Vaccines, vol. 5, no. 1, 7 . https://doi.org/10.1038/s41541-020-0157-x
NPJ Vaccines
Nguyen, N D N T, Olsen, A W, Lorenzen, E, Andersen, P, Hvid, M, Follmann, F & Dietrich, J 2020, ' Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge ', npj Vaccines, vol. 5, no. 1, 7 . https://doi.org/10.1038/s41541-020-0157-x
The optimal protective immunity against Chlamydia trachomatis (C.t.) is still not fully resolved. One of the unresolved issues concerns the importance of resident immunity, since a recent study showed that optimal protection against a transcervical (