Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anja U. van Lent"'
Autor:
Emile E. Voest, Elvira Nuijten, Monique E. van Leerdam, Arend G. J. Aalbers, Annegien Broeks, José G van den Berg, Niels F. M. Kok, Marleen Kok, Wieke H M Verbeek, Petur Snaebjornsson, Myriam Chalabi, Lorenzo F. Fanchi, Ton N. Schumacher, Gergana Bounova, Maria Kuiper, Krijn K. Dijkstra, Monique Maas, Geerard L. Beets, Anja U. van Lent, John B. A. G. Haanen, Vivien Veninga, Marta Lopez-Yurda, Regina G. H. Beets-Tan, Thomas R de Wijkerslooth, Cecile Grootscholten, Hendrik A Marsman, Karolina Sikorska, Marjolijn Mertz
Publikováno v:
Nature Medicine, 26(4), 566-576. Nature Publishing Group
PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) tumors. We postulated a higher efficacy of neoadjuvant immunotherapy in early-stage colon can
Autor:
Jacques J. Bergman, Wouter L. Curvers, Marijn J. Warners, Anja U. van Lent, Noor L. Bekkali, R. Bart Takkenberg, Bram D. van Rhijn, Albert J. Bredenoord, Paul Fockens, Jaap J. Kloek
Publikováno v:
Endoscopy, 46(12), 1049-1055. Georg Thieme Verlag
Background and study aims: Recently the Endoscopic Reference Score (EREFS) for endoscopic assessment of eosinophilic esophagitis was introduced, with good interobserver agreement for most signs. The EREFS has not yet been evaluated by other investiga
Autor:
Hergen Spits, Bianca Blom, Maho Nagasawa, Kees Weijer, Anja U. van Lent, Ferenc A. Scheeren, Nicolas Legrand
Publikováno v:
European Journal of Immunology. 40:955-965
Thymic stromal lymphopoietin (TSLP) is a cytokine that binds the IL-7-receptor-alpha chain and a unique TSLP receptor (TSLPR) chain. The role of TSLP in human B-cell development has not been elucidated. We show that TSLPR transcripts are expressed mo
Autor:
Rudi Balling, Kees Weijer, James P. Di Santo, Patrick Ziegler, Markus G. Manz, Richard A. Flavell, Chozhavendan Rathinam, Pablo D. Becker, Charles M. Rice, Anja U. van Lent, Chiara Borsotti, Nicolas Brezillon, Nicolas Legrand, Elizabeth E. Eynon, Michael Ott, Chengyan Wang, Ype P. de Jong, Jean Jacques Mention, Hélène Strick-Marchand, Stephanie C. Eisenbarth, Sean Stevens, Nicholas D. Huntington, Anthony Rongvaux, Hergen Spits, Alexander Ploss, Hitoshi Takizawa, Dina Kremsdorf, Hongkui Deng, Tim Willinger, Carlos A. Guzmán, Michael Manns, Jennifer Debarry
Publikováno v:
Cell host & microbe, 6(1), 5-9. Cell Press
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for devel
Autor:
Ton N. Schumacher, Anja U. van Lent, Mirjam H.M. Heemskerk, Nicolas Legrand, Hergen Spits, Marleen M. van Loenen, Maho Nagasawa, Remko Schotte
Publikováno v:
Journal of immunology (Baltimore, Md., 179(8), 4959-4968. American Association of Immunologists
In vitro production of human T cells with known Ag specificity is of major clinical interest for immunotherapy against tumors and infections. We have performed TCRαβ gene transfer into human hemopoietic progenitors from postnatal thymus or umbilica
Publikováno v:
Seminars in immunology. 19(5):280-288
The thymus supports the development of T cells throughout life from hematopoietic progenitor cells migrating from the bone marrow. During the early years after birth thymic activity is highest, but progressively declines resulting in diminished naive
Autor:
Hergen Spits, Nicolas Legrand, Anja U. van Lent, Thomas Hanke, Tom Cupedo, Kees Weijer, Menno J. Ebeli
Publikováno v:
Blood, 108(1), 238-245. American Society of Hematology
Efficient and quick reconstitution of T-cell compartments in lymphopenic patients is of great importance to prevent opportunistic infections, but remains difficult to achieve. Human T-cell proliferation in a T-cell-receptor (TCR)-independent manner i
Publikováno v:
van Lent, A U, Takkenberg, R B, van Eeden, S, Mulder, C J J & Beuers, U 2015, ' Chronic diarrhea because of villous atrophy unrelated to celiac disease ', Endoscopy, vol. 47, pp. E71-E72 . https://doi.org/10.1055/s-0034-1391247
Endoscopy, 47, E71-E72. Georg Thieme Verlag
Endoscopy, 47(Suppl. 1 UCTN), E71-E72. Georg Thieme Verlag
Endoscopy, 47, E71-E72. Georg Thieme Verlag
Endoscopy, 47(Suppl. 1 UCTN), E71-E72. Georg Thieme Verlag
Autor:
Anja U. van Lent, Geert R D'Haens
Publikováno v:
Digestive diseases (Basel, Switzerland), 31(2), 222-228. S. Karger AG
The course of Crohn's disease (CD) is unpredictable and potentially destructive. The percentage of patients requiring surgery at some stage in their disease accumulates to over 70%. After resection of the affected intestine, reappearance of CD occurs
Autor:
Anja U, van Lent, Mireille, Centlivre, Maho, Nagasawa, Julien J, Karrich, Stephan M, Pouw, Kees, Weijer, Hergen, Spits, Bianca, Blom, Nicolas, Legrand
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 595
Over the last two decades, several humanized mouse models have been used to experimentally analyze the function and development of the human immune system. Recent advances have lead to the establishment of new murine-human chimeric models with improv