Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Anja U. Bräuer"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The retinal degeneration protein RD3 is involved in regulatory processes of photoreceptor cells. Among its main functions is the inhibition of photoreceptor specific membrane guanylate cyclases during trafficking from the inner segment to their final
Externí odkaz:
https://doaj.org/article/8a4f459ec56c44c5955c84158eacd416
Autor:
Isabel Gross, Nicola Brandt, Danara Vonk, Franziska Köper, Lars Wöhlbrand, Ralf Rabus, Martin Witt, Axel Heep, Torsten Plösch, Mark S. Hipp, Anja U. Bräuer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
During adult neurogenesis, neuronal stem cells differentiate into mature neurons that are functionally integrated into the existing network. One hallmark during the late phase of this neurodifferentiation process is the formation of dendritic spines.
Externí odkaz:
https://doaj.org/article/bc340cad538f4d87bae896fb81e63a42
Autor:
Natalie Gray, Maren M. Limberg, Daniela Wiebe, Tobias Weihrauch, Anna Langner, Nicola Brandt, Anja U. Bräuer, Ulrike Raap
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16117 (2022)
Basophils are key effector cells in atopic diseases, and the signaling sphingolipid Sphigosine-1-phosphate (S1P) is emerging as an important mediator in these conditions. The possible interaction of S1P and basophils and the resulting biological effe
Externí odkaz:
https://doaj.org/article/13ca43b7c4e74b0491af2936fd18f78d
Autor:
Gabriel M. S. Janach, Olivia Reetz, Noah Döhne, Konstantin Stadler, Sabine Grosser, Egor Byvaltcev, Anja U. Bräuer, Ulf Strauss
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and d
Externí odkaz:
https://doaj.org/article/f2bc1f3ce63b4b888259b67d1e61434f
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 123-130 (2019)
Manipulation of pre-mRNA processing is a promising approach toward overcoming disease-causing mutations and treating human diseases. We show that a combined treatment applying two splice-manipulating technologies improves therapeutic efficacies to co
Externí odkaz:
https://doaj.org/article/74d2e42aad1243f58059fb9674fc0ac2
Autor:
Nicola Brandt, Jan Philipp Willmer, Maurilyn S. Ayon-Olivas, Veronika Banicka, Martin Witt, Andreas Wree, Isabel Groß, Anne Gläser, Jens Hausmann, Anja U. Bräuer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13007 (2022)
The functional importance of neuronal differentiation of the transmembrane proteins’ plasticity-related genes 3 (PRG3) and 5 (PRG5) has been shown. Although their sequence is closely related, they promote different morphological changes in neurons.
Externí odkaz:
https://doaj.org/article/65200e1bd18e4343bdc2432e75b0887b
Autor:
Anna-Maria Neßlauer, Anne Gläser, Markus Gräler, Robby Engelmann, Brigitte Müller-Hilke, Marcus Frank, Christine Burstein, Arndt Rolfs, John Neidhardt, Andreas Wree, Martin Witt, Anja U. Bräuer
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-18 (2019)
Abstract Background Niemann-Pick disease type C1 (NPC1) is an autosomal-recessive lipid-storage disorder with an estimated minimal incidence of 1/120,000 live births. Besides other neuronal and visceral symptoms, NPC1 patients develop spleen dysfunct
Externí odkaz:
https://doaj.org/article/a0419c4954524ee0a8181407b24c077c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2300 (2022)
Loss of active synapses and alterations in membrane lipids are crucial events in physiological aging as well as in neurodegenerative disorders. Both are related to the abnormal aggregation of amyloid-beta (Aβ) species, generally known as amyloidosis
Externí odkaz:
https://doaj.org/article/4598f1d7cefc461eb4ebd58e6efb4056
Autor:
Anja Meyer, Anne Gläser, Anja U. Bräuer, Andreas Wree, Jörg Strotmann, Arndt Rolfs, Martin Witt
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 12 (2018)
Background: Neurodegenerative diseases are often accompanied by olfactory deficits. Here we use a rare neurovisceral lipid storage disorder, Niemann–Pick disease C1 (NPC1), to illustrate disease-specific dynamics of olfactory dysfunction and its re
Externí odkaz:
https://doaj.org/article/7d0bee0707ea4b09ac54157bfa6cda24
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4392 (2019)
Rare diseases are a heterogeneous group of very different clinical syndromes. Their most common causes are defects in the hereditary material, and they can therefore be passed on to descendants. Rare diseases become manifest in almost all organs and
Externí odkaz:
https://doaj.org/article/8f0d777e71c44cdd85a19c16d1480fda