Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Anja Sandström"'
Autor:
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O. Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J. Craig, Yoseph Atilaw, Anja Sandström, Lindon W. K. Moodie, Åke Lundkvist, Martijn J. van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U. Helena Danielson, Jens Carlsson
Publikováno v:
Journal of the American Chemical Society, 144(7), 2905-2920. AMER CHEMICAL SOC
Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c3c3e10aa0c690988b970c049d161
http://hdl.handle.net/1887/3479854
http://hdl.handle.net/1887/3479854
Autor:
Anja Sandström, Andrea Benediktsdottir, Yantao Chen, Praveen K. Chinthakindi, Per I. Arvidsson
Publikováno v:
European Journal of Organic Chemistry. 2020:3796-3807
Many synthetic routes have been explored to make small molecule sulfonimidamides (SIAs), however, its introduction into larger molecules such as oligopeptides has not been studied before. We herein ...
Autor:
Siew Yeen Chai, Anja Sandström, Nicholas Barlow, Mats Larhed, Philip E. Thompson, Anders Hallberg, Sudarsana Reddy Vanga, Jonas Sävmarker, Johan Åqvist, Peta Burns, Hugo Gutiérrez-de-Terán, Mathias Hallberg
Publikováno v:
RSC Med Chem
Macrocyclic analogues of the linear hexapeptide, angiotensin IV (AngIV) have proved to be potent inhibitors of insulin-regulated aminopeptidase (IRAP, oxytocinase, EC 3.4.11.3). Along with higher affinity, macrocycles may also offer better metabolic
Autor:
Edouard Zamaratski, Carl-Johan Aurell, Anna Pettersen, Atta Wared, Per I. Arvidsson, Andrea Benediktsdottir, Yantao Chen, Ayah Ibrahim, Anja Sandström, Praveen K. Chinthakindi
Publikováno v:
European Journal of Organic Chemistry. 2019:1045-1057
Herein, we report the synthesis of novel sulfonimidamides (SIAs) based on amino acid building blocks using a one-pot method from tert-butyldiphenylsilyl-protected (TBDPS) sulfonamides, as well as e ...
Autor:
Åke Lundkvist, Dario Akaberi, Navaneethan Palanisamy, Amanda Båhlström, Josef D. Järhult, Tomas Nyman, Johan Lennerstrand, Praveen K. Chinthakindi, Anja Sandström
Publikováno v:
Antiviral Research
Tick-borne encephalitis (TBE) is a severe neurological disorder caused by tick-borne encephalitis virus (TBEV), a member of the Flavivirus genus. Currently, two vaccines are available in Europe against TBEV. However, TBE cases have been rising in Swe
Autor:
Sha Cao, Diarmaid Hughes, Andrea Benediktsdottir, Anders Karlén, Sherry L. Mowbray, Anja Sandström, Lu Lu, Edouard Zamaratski
Oligopeptide boronates with a lipophilic tail are known to inhibit the type I signal peptidase in E. coli, which is a promising drug target for developing novel antibiotics. Antibacterial activity depends on these oligopeptides having a cationic modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81bc1a93d6f4063bfe71b7fc5ad074d
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450022
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450022
Autor:
Anja Sandström, Navaneethan Palanisamy, Johan Lennerstrand, Åke Lundkvist, Amanda Båhlström, Dario Akaberi, Praveen K. Chinthakindi
Publikováno v:
Journal of biomolecular structuredynamics. 38(18)
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus and infection by ZIKV Asian lineage is known to cause fetal brain anomalies and Guillain-Barrés syndrome. The WHO declared ZIKV a global public health emergency in 2016. However, currently n
Autor:
Shanti Diwakarla, Christian Sköld, Anna Jonsson, Mathias Hallberg, Rebecca Fransson, Richard Svensson, Anna Skogh, Anna Lesniak, Maria Karlgren, Anja Sandström, Fabienne Z. Gaugaz, Fred Nyberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2446-2450
The dipeptide amide H-Phe-Phe-NH2 (1) that previously was identified as a ligand for the substance P 1-7 (SP1-7) binding site exerts intriguing results in animal models of neuropathic pain after central but not after peripheral administration. The di
Autor:
Anja Sandström, Eldar Abdurakhmanov, Eva Åkerblom, Anna Karin Belfrage, U. Helena Danielson, Hiba Alogheli, Peter Brandt, Johan Neyts
Publikováno v:
European Journal of Medicinal Chemistry. 148:453-464
Herein, we present the design and synthesis of 2(1H)-pyrazinone based HCV NS3 protease inhibitors and show that elongated R-3 urea substituents were associated with increased inhibitory potencies o ...
Autor:
Mathias Hallberg, Richard Svensson, Rebecca Fransson, Fabienne Z. Gaugaz, Anja Sandström, Anna Skogh, Anna Lesniak, Fred Nyberg, Gunnar Lindeberg
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:533-540
Substance P 1-7 (SP1-7, Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP). This heptapeptide often oppose ...