Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anja Ruppelt"'
Publikováno v:
Scandinavian Journal of Immunology. 74:568-573
The distal pole complex (DPC) assembles signalling proteins at the T cell pole opposite the immunological synapse (IS) and is thought to facilitate T cell activation by sequestering negative regulatory molecules away from the T cell receptor-proximal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8779531ab25bdf16423c5c33ec9649
https://doi.org/10.1111/j.1365-3083.2011.02611.x
https://doi.org/10.1111/j.1365-3083.2011.02611.x
Autor:
Mikael Heglind, Randi Mosenden, Michel Moutschen, Anja Ruppelt, Pratibha Singh, Souad Rahmouni, Kjetil Taskén, Sven Enerbäck, Isabelle Cornez
Publikováno v:
The Journal of Immunology. 186:5119-5130
Type I protein kinase A (PKA) is targeted to the TCR-proximal signaling machinery by the A-kinase anchoring protein ezrin and negatively regulates T cell immune function through activation of the C-terminal Src kinase. RI anchoring disruptor (RIAD) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2e4356a4044bd63eeada73d4134363
https://doi.org/10.4049/jimmunol.1100003
https://doi.org/10.4049/jimmunol.1100003
Publikováno v:
Biochemical Journal. 425:381-388
We recently reported that the dual-specificity AKAP (A-kinaseanchoring protein) Ezrin targets type I PKA (protein kinase A) to the vicinity of the TCR (T-cell receptor) in T-cells and, together with PAG (phosphoprotein associated with glycosphingolip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c1fd9d55f0383db174964c41bd7463
https://doi.org/10.1042/bj20091136
https://doi.org/10.1042/bj20091136
Autor:
Kjetil Taskén, Anja Ruppelt, Birgitte Lygren, Elisabeth Jarnæss, Anne Jorunn Stokka, John D. Scott
Publikováno v:
Journal of Biological Chemistry. 283:33708-33718
A-kinase anchoring proteins (AKAPs) target protein kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18-amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R) subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d78e12694bd97c1fc4ceae1becf98e
https://doi.org/10.1074/jbc.m804807200
https://doi.org/10.1074/jbc.m804807200
Publikováno v:
Journal of Molecular Biology. 327:609-618
Protein kinase A (PKA) regulatory (R) subunits dimerize through an N-terminal motif. Such dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action. In the present study, we used the yeast two-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f11b70bb5a0d9734963dbed873852d
https://doi.org/10.1016/s0022-2836(03)00093-7
https://doi.org/10.1016/s0022-2836(03)00093-7
Autor:
Randi Mosenden, Kjetil Taskén, Mikaela Grönholm, Anja Ruppelt, Olli Carpén, Einar Martin Aandahl, Friedrich W. Herberg, Cathrine R. Carlson, Derek Tobin, Hilde Abrahamsen
Publikováno v:
The Journal of Immunology. 186:7269-7271
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31acb18ea153c36ab372669614a51244
https://doi.org/10.4049/jimmunol.1190024
https://doi.org/10.4049/jimmunol.1190024
Genomic structure, developmental distribution and functional properties of the chicken P2X5 receptor
Publikováno v:
Journal of Neurochemistry. 77:1256-1265
We report here the cloning of a chicken cDNA (402 aa) showing high sequence similarity to the previously cloned rat and human P2X5 receptors (67 and 69%, respectively). The chicken P2X5 subunit is encoded by a gene composed of 12 translated exons, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9d7063b4a57f996542f352987432eef
https://doi.org/10.1046/j.1471-4159.2001.00348.x
https://doi.org/10.1046/j.1471-4159.2001.00348.x
Publisher Summary This chapter presents the data regarding the total availability of PKA and PKG consensus sites in the human proteome, estimates frequencies of phosphorylation of different motifs, and attempt to give an overview of physiological sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064e576d316e74ed1e988362063fc9f1
https://doi.org/10.1016/b978-0-12-374145-5.00183-2
https://doi.org/10.1016/b978-0-12-374145-5.00183-2
Autor:
Kjetil Taskén, Mikaela Grönholm, Randi Mosenden, Hilde Abrahamsen, Anja Ruppelt, Friedrich W. Herberg, Cathrine R. Carlson, Olli Carpén, Einar Martin Aandahl, Derek Tobin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 179(8)
cAMP negatively regulates T cell immune responses by activation of type I protein kinase A (PKA), which in turn phosphorylates and activates C-terminal Src kinase (Csk) in T cell lipid rafts. Using yeast two-hybrid screening, far-Western blot, immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3f77348d6087f676e9ded438953cc0
https://pubmed.ncbi.nlm.nih.gov/17911601
https://pubmed.ncbi.nlm.nih.gov/17911601
Autor:
Ralf Wagner, Kjetil Taskén, Kalle Saksela, Tapio Kesti, Anja Ruppelt, Jing-Huan Wang, Michael A. Liss
Publikováno v:
University of Helsinki
Recruitment of cellular signaling proteins by the CD3 polypeptides of the TCR complex mediates T cell activation. We have screened a human Src homology 3 (SH3) domain phage display library for proteins that can bind to the proline-rich region of CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0323417b1d9cf643d8399f7af39eb691
https://pubmed.ncbi.nlm.nih.gov/17617578
https://pubmed.ncbi.nlm.nih.gov/17617578