Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anja Rode"'
Autor:
Zoe June F. Assaf, Wei Zou, Alexander D. Fine, Mark A. Socinski, Amanda Young, Doron Lipson, Jonathan F. Freidin, Mark Kennedy, Eliana Polisecki, Makoto Nishio, David Fabrizio, Geoffrey R. Oxnard, Craig Cummings, Anja Rode, Martin Reck, Namrata S. Patil, Mark Lee, David S. Shames, Katja Schulze
Publikováno v:
Nature Medicine. 29:859-868
One of the great challenges in therapeutic oncology is determining who might achieve survival benefits from a particular therapy. Studies on longitudinal circulating tumor DNA (ctDNA) dynamics for the prediction of survival have generally been small
Autor:
James Unwin, Felix Allum, Mathew Britton, Ian Gabalski, Hubertus Bromberger, Mark Brouard, Philip H. Bucksbaum, Taran Driver, Nagitha Ekanayake, Diksha Garg, Eva Gougoula, David Heathcote, Andrew J. Howard, Paul Hockett, David M. P. Holland, Sonu Kumar, Chow-shing Lam, Jason W. L. Lee, Joseph McManus, Jochen Mikosch, Dennis Milesevic, Russell S. Minns, Christina C. Papadopoulou, Christopher Passow, Weronika O. Razmus, Anja Röder, Arnaud Rouzée, Michael Schuurman, Alcides Simao, Albert Stolow, Atia Tul-Noor, Claire Vallance, Tiffany Walmsley, Daniel Rolles, Benjamin Erk, Michael Burt, Ruaridh Forbes
Publikováno v:
Communications Physics, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Structural imaging of transient excited-state species is a key goal of molecular physics, promising to unveil rich information about the dynamics underpinning photochemical transformations. However, separating the electronic and nuclear cont
Externí odkaz:
https://doaj.org/article/d31d80e762d54889963c81d3b0d3cf5d
Publikováno v:
Vaccines, Vol 12, Iss 5, p 524 (2024)
Adenoviruses are efficient and safe vectors for delivering target antigens and adenovirus-based vaccines have been used against a wide variety of pathogens, including tuberculosis and COVID-19. Cost-effective and scalable biomanufacturing processes a
Externí odkaz:
https://doaj.org/article/73dc1a4654dc433ab6363bfeb86b5dfc
Autor:
Raymond Evers, Nico Scheer, Anja Rode, Laurent Salphati, Xiaoyan Chu, Robert A.B. van Waterschoot, Jodie Pang, Jashvant D. Unadkat, Jeevan Kunta, Liangfu Chen, Matthew G. Soars, Loic Laplanche, Shannon Dallas, Jocelyn Yabut, Alfred H. Schinkel, Mario Mezler, Bhagwat Prasad, Ethan G. Geier, Jonathan R Kehler, Donna Mamaril-Fishman
Publikováno v:
Drug Metabolism and Disposition. 42:1301-1313
Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to bett
Autor:
A. Kenneth MacLeod, Nico Scheer, Colin J. Henderson, Anja Rode, Lesley A. McLaughlin, C. Roland Wolf
Publikováno v:
Drug Metabolism and Disposition. 42:1022-1030
In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80% of this activity. There are profound species differences in the multipl
Autor:
Colin J. Henderson, Nico Scheer, Yury Kapelyukh, Aileen McLaren, Kenneth MacLeod, Anja Rode, De Lin, C Roland Wolf
Publikováno v:
Cancer Research. 79:2933-2933
A vast number of targeted anticancer drugs are being developed in the pharmaceutical industry whose efficacy will only become fully realized through their combination with other established or novel anti-tumor agents. This is particularly the case be
Publikováno v:
Molecular Pharmacology. 82:1022-1029
Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-t
Autor:
Anja Rode, Xiaoyan Chu, Esaie Pierre, Thomas Wanek, Jeevan Kunta, Mario Mezler, Clara Andonian, Jocelyn Yabut, Jodie Pang, Carolin Hoft, Stéphanie Chasseigneaux, Shannon Dallas, Oliver Langer, Xiaolin Zhang, Damir Simic, David Gomez-Zepeda, Karen DiLoreto, Liangfu Chen, Loic Laplanche, Tony Pereira, Marie-Claude Menet, Laurent Salphati, Nico Scheer, Xavier Declèves
Publikováno v:
Molecular pharmacology. 89(5)
Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby
Autor:
Anja Rode, Clifford R. Elcombe, Simon Plummer, Nico Scheer, C. Roland Wolf, Ortwin Vogel, Jillian Ross, Conrad C. Bower, Colin J. Henderson
Publikováno v:
Toxicological Sciences. 116:452-466
Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to h
Publikováno v:
Drug Metabolism and Disposition. 38:1046-1053
Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of ma