Výsledky vyhledávání - "Anja R. Oldenburg"

The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks

Autor: Marie Garcia, Anne-Claire Guénantin, Anja R. Oldenburg, Emilie Capel, Jean-Sébastien Hulot, Jonas Paulsen, Nolwenn Briand, Akshay Shah, Corinne Vigouroux, Matthieu Mantecon, Philippe Collas, Dorota Jeziorowska

Publikováno v: Human Molecular Genetics. 27:1447-1459

The p.R482W hotspot mutation in A-type nuclear lamins causes familial partial lipodystrophy of Dunnigan-type (FPLD2), a lipodystrophic syndrome complicated by early onset atherosclerosis. Molecular mechanisms underlying endothelial cell dysfunction c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480de7fadb8c8c41ebc80e7846368a8a
https://doi.org/10.1093/hmg/ddy055

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A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus

Autor: Jan Øivind Moskaug, Anita L. Sørensen, Anja R. Oldenburg, Philippe Collas, Nolwenn Briand, Inswasti Cahyani, Akshay Shah

Publikováno v: Journal of Cell Biology. 216:2731-2743

Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies, which include partial lipodystrophies associated with metabolic syndromes. The lipodystrophy-associated LMNA p.R482W mutation is known to impair adipogenic differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77e99faca5e6d834636db07c55cf5ed8
https://doi.org/10.1083/jcb.201701043

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Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression

Autor: Philippe Collas, Anja R. Oldenburg, Eivind G. Lund

Publikováno v: BioEssays. 36:75-83

The nuclear envelope shapes the functional organization of the nucleus. Increasing evidence indicates that one of its main components, the nuclear lamina, dynamically interacts with the genome, including the promoter region of specific genes. This se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239316e0f48dd3aa35fcc5058e303bd2
https://doi.org/10.1002/bies.201300138

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Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes

Autor: Philippe Collas, Corinne Vigouroux, Anja R. Oldenburg, Bernd Thiede, Erwan Delbarre

Publikováno v: Human Molecular Genetics. 23:1151-1162

The nuclear lamina is implicated in the regulation of various nuclear functions. Several laminopathy-causing mutations in the LMNA gene, notably the p.R482W substitution linked to familial partial lipodystrophy type 2 (FPLD2), are clustered in the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9854602e5b11b4bb7e39135c7c75493
https://doi.org/10.1093/hmg/ddt509

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Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts

Autor: Jonas Paulsen, Monika Sekelja, Corinne Vigouroux, Anja R. Oldenburg, Anita L. Sørensen, Akshay Shah, Nolwenn Briand, Erwan Delbarre, Alice Barateau, Brigitte Buendia, Philippe Collas

Publikováno v: Genome Biology
Genome Biology, 2017, 18, pp.21. ⟨10.1186/s13059-016-1146-2⟩
Genome Biology, BioMed Central, 2017, 18, pp.21. ⟨10.1186/s13059-016-1146-2⟩

Current three-dimensional (3D) genome modeling platforms are limited by their inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user-friendly whole-genome 3D computational modeling framework that simulates positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c42e03454f69399cdab8e04f396e007
http://europepmc.org/articles/PMC5278575

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Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins

Autor: Anja R, Oldenburg, Philippe, Collas

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1411

The nuclear lamina is a meshwork of A- and B-type lamins which interact with chromatin and regulate many nuclear functions. Recent studies have reported the discovery of chromatin domains interacting with nuclear lamins by chromatin immunoprecipitati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2614c288426d4abcc133128a0f072b5
https://pubmed.ncbi.nlm.nih.gov/27147051

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Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins

Autor: Philippe Collas, Anja R. Oldenburg

Publikováno v: Methods in Molecular Biology ISBN: 9781493935284

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94362cab556c31474b0c75e4d5423a3a
https://doi.org/10.1007/978-1-4939-3530-7_20

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Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B

Autor: Torunn Rønningen, Akshay Shah, Philippe Collas, Anja R. Oldenburg, Kristin Vekterud, Erwan Delbarre, Jan Øivind Moskaug

Publikováno v: Genome research. 25(12)

Dynamic interactions of nuclear lamins with chromatin through lamin-associated domains (LADs) contribute to spatial arrangement of the genome. Here, we provide evidence for prepatterning of differentiation-driven formation of lamin A/C LADs by domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773cb8c83ec1aeb882da2e72162548fb
https://pubmed.ncbi.nlm.nih.gov/26359231

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Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

Autor: Brigitte Buendia, Eivind G. Lund, Isabelle Duband-Goulet, Anja R. Oldenburg, Philippe Collas

The nuclear lamina has been shown to interact with the genome through lamina-associated domains (LADs). LADs have been identified by DamID, a proximity labeling assay, and more recently by chromatin immunoprecipitation-sequencing (ChIP-seq) of A- and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9adda348fd4375cfd29d97bf6cb320e
https://europepmc.org/articles/PMC4615303/

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The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy

Autor: Philippe Collas, Nathalie Vadrot, Nolwenn Briand, Wikayatou Attanda, Anja R. Oldenburg, Brigitte Buendia, Eva Cabet, Patrick Vicart, Isabelle Duband-Goulet, Alice Barateau, Eivind G. Lund, Corinne Vigouroux, Fabien Gerbal

Publikováno v: Human molecular genetics. 24(7)

Nuclear lamins are involved in many cellular functions due to their ability to bind numerous partners including chromatin and transcription factors, and affect their properties. Dunnigan type familial partial lipodystrophy (FPLD2; OMIM#151660) is cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003b6b85dcec0bafbe68206334e28e0f
https://pubmed.ncbi.nlm.nih.gov/25524705

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