Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anja Pfaus"'
Autor:
Julia Weber, Jorge de la Rosa, Carolyn S. Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J. Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A. Turchaninova, Anna Scherger, Gary J. Hoffman, Julia Hess, Laura B. Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M. Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S. Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor s
Externí odkaz:
https://doaj.org/article/3cd9593b5a3c449085e3011eabf08516
Autor:
Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Christian J. Braun, Dieter Saur, Stefan Engelhardt, Roland Rad
Publikováno v:
Nature Protocols. 17:1142-1188
Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic stem cells. Here, we describe methods for rapid and scalable genome engineering in somatic cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9091e68d2e2d16bfdb1ba335d8a58f
https://doi.org/10.1038/s41596-021-00677-0
https://doi.org/10.1038/s41596-021-00677-0
Autor:
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Pfaus, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas
SUMMARY PARAGRAPHDisease-causing mutations in genes encoding transcription factors (TFs) are a recurrent finding in hematopoietic malignancies and might involve key regulators of lineage adherence and cellular differentiation1–3. Such mutations can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd3316c398bb4961ae21419171bf62ab
https://doi.org/10.1101/2022.12.29.522203
https://doi.org/10.1101/2022.12.29.522203
Autor:
Carsten Müller-Tidow, Ya-Yun Cheng, J. Holtmann, S. Rudat, Claudia Wickenhauser, Jana M. Ellegast, Esteban Martínez, Stefan Fröhling, Lars Bullinger, Michael D. Milsom, Christoph Lutz, Anja Pfaus, Daniela Di Marcantonio, Claudia Scholl, Stefanie Göllner, Stephen M. Sykes, C. Bühler
Publikováno v:
Leukemia. 32:2189-2202
Many cases of AML are associated with mutational activation of receptor tyrosine kinases (RTKs) such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is driven by concomitant activation of differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9557a4656b916c8d86d60bc2f4fdeb
https://doi.org/10.1038/s41375-018-0102-4
https://doi.org/10.1038/s41375-018-0102-4
Autor:
Thomas Engleitner, Fengtang Yang, Kristian Unger, Robert Lersch, Gary J. Hoffman, Julia Hess, Mathias J Friedrich, Ruby Banerjee, Lena Rad, Michael Grau, Georg Lenz, Mathias Heikenwalder, Ursula Kohlhofer, Anna Katharina Scherger, Olga Baranov, Manuela Martella, Juan Cadiñanos, Jorge de la Rosa, Tim Ammon, Ulrich Keller, Rupert Öllinger, Leticia Quintanilla-Martinez, Günter Schneider, Carolyn S. Grove, Anja Pfaus, Allan Bradley, Irene Gonzalez Menendez, George S. Vassiliou, Marc Schmidt-Supprian, Alexander Strong, Maria A. Turchaninova, Julia Weber, Johnny Kim, Dmitriy M. Chudakov, Dieter Saur, Laura B. Kuhn, Ursula Zimber-Strobl, Pentao Liu, Roland Rad, Markus Schick, Katja Steiger
Publikováno v:
Nat. Commun. 10:1415 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon tools and mouse models fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d2644306f9283cc916d9683eb98d43
https://mediatum.ub.tum.de/1544144
https://mediatum.ub.tum.de/1544144
Autor:
Thomas Engleitner, Dieter Saur, Lena Rad, Allan Bradley, Wei Wang, Pentao Liu, Alexander Strong, Mathias J Friedrich, Iraad F. Bronner, Hannes Ponstingl, Carolyn Grove, Anja Pfaus, Matthew Mayho, Roland Rad, Michael A. Quail, George S. Vassiliou, Julia Weber, Juan Cadiñanos
Publikováno v:
Nature Protocols
Transposon-mediated forward genetics screening in mice has emerged as a powerful tool for cancer gene discovery. It pinpoints cancer drivers that are difficult to find with other approaches, thus complementing the sequencing-based census of human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b0f7f6cb202283569ef2d089f81477
https://pubmed.ncbi.nlm.nih.gov/28079877
https://pubmed.ncbi.nlm.nih.gov/28079877
Autor:
Jana M. Ellegast, Saskia Rudat, Stefan Gröschel, Claudia Scholl, Lars Bullinger, Michael D. Milsom, Stefan Fröhling, Anja Pfaus, Sophie Rabe, Claudia Bühler, Stephen M. Sykes
Publikováno v:
Blood. 128:2849-2849
Acute myeloid leukemia (AML) is a heterogeneous disease with diverse leukemogenic driver lesions. The genetic understanding of AML has resulted in major improvements in diagnosis, classification, prognostication, and outcome prediction. However, thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1be152d7ce9786cc9fe204f9e3cf6a
https://doi.org/10.1182/blood.v128.22.2849.2849
https://doi.org/10.1182/blood.v128.22.2849.2849