Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Anja Palusczak"'
Autor:
Constanze Paulus, Maksym Myronovskyi, Josef Zapp, Marta Rodríguez Estévez, Maria Lopatniuk, Birgit Rosenkränzer, Anja Palusczak, Andriy Luzhetskyy
Publikováno v:
Microorganisms, Vol 10, Iss 9, p 1752 (2022)
Natural products derived from plants, fungi or bacteria have been used for years in the medicine, agriculture and food industries as they exhibit a variety of beneficial properties, such as antibiotic, antifungal, anticancer, herbicidal and immunosup
Externí odkaz:
https://doaj.org/article/4d0a6ca1a0ef4febae6efeb33e141608
Publikováno v:
Microorganisms, Vol 9, Iss 8, p 1609 (2021)
Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal-p
Externí odkaz:
https://doaj.org/article/ff6e1de6effb4613b8bcff43e274f9be
Publikováno v:
Microorganisms
Volume 9
Issue 8
Microorganisms, Vol 9, Iss 1609, p 1609 (2021)
Volume 9
Issue 8
Microorganisms, Vol 9, Iss 1609, p 1609 (2021)
Targeted genome mining is an efficient method of biosynthetic gene cluster prioritization within constantly growing genome databases. Using two capreomycidine biosynthesis genes, alpha-ketoglutarate-dependent arginine beta-hydroxylase and pyridoxal-p
Autor:
Constanze, Lasch, Nils, Gummerlich, Maksym, Myronovskyi, Anja, Palusczak, Josef, Zapp, Andriy, Luzhetskyy
Publikováno v:
Molecules
Natural products are a valuable source of biologically active compounds with potential applications in medicine and agriculture. Unprecedented scaffold diversity of natural products and biocatalysts from their biosynthetic pathways are of fundamental
Autor:
Rolf W. Hartmann, Guillaume Le Baut, Marie-Pierre Lézé, Anja Palusczak, Muriel Duflos, Marc Le Borgne, Patricia Pinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1134-1137
The synthesis and the aromatase (CYP19) inhibitory activity of 5-[(aryl)(imidazol-1-yl)methyl]-1H-indoles were reported. Among the tested racemate compounds, 5-[(4-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-indole 8b emerged as a potent CYP19 inhibito
Autor:
Volker Huch, Rolf W. Hartmann, Markus Hector, Martina Palzer, Anja Palusczak, Bertil Wachall, Michael Veith
Publikováno v:
Journal of Medicinal Chemistry. 43:4437-4445
In the search for potent inhibitors of P450 17, the key enzyme in androgen biosynthesis, a series of steroidal inhibitors were synthesized and tested toward rat and human P450 17. Small aliphatic heterocycles (aziridine, oxirane, thiirane, diaziridin
Publikováno v:
European Journal of Medicinal Chemistry. 35:931-940
A Negishi-type coupling reaction between 6-bromo-2-methoxyquinoline ( 1a ) and various 4-bromo- N , N -dialkyl-benzamides gave access to 6-substituted 2-methoxy-quinolines 1 - 3 and 1 H -quinolin-2-ones 4 – 12 . Most of these compound proved to be
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4713-4715
Two new series of benzonitrile derivatives on position 6 or 4 of indole ring were successfully synthesized via a Leimgruber–Batcho reaction. All the compounds were evaluated in vitro on the inhibition of aromatase (CYP19) and 17α-hydroxylase-C17,2
Autor:
Thierry Langer, Theodora M. Steindl, Anja Palusczak, Christian Laggner, Daniela Schuster, Rolf W. Hartmann
Publikováno v:
ChemInform. 37
Cytochrome P450 19 (P450 19, aromatase) constitutes a successful target for the treatment of breast cancer. This study analyzes chemical features common to P450 19 inhibitors to develop ligand-based, selective pharmacophore models for this enzyme. Th
Autor:
Marc Le Borgne, Marie-Pierre Lézé, Manuela Kogler, Guillaume Le Baut, Anja Palusczak, Denis Loquet, Rolf W. Hartmann, Pascal Marchand
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2004, 19 (6), pp.549-557. ⟨10.1080/14756360400004631⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2004, 19 (6), pp.549-557. ⟨10.1080/14756360400004631⟩
The present study was designed to follow our pharmacomodulation work in the field of non-steroidal aromatase inhibitors. All target compounds 12a-h and 28a-h were tested in vitro for human placental aromatase inhibition, using testosterone or androst