Contribution of an aged microenvironment to aging-associated myeloproliferative disease.

Autor: Virag Vas, Corinna Wandhoff, Karin Dörr, Anja Niebel, Hartmut Geiger

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31523 (2012)

The molecular and cellular mechanisms of the age-associated increase in the incidence of acute myeloid leukemia (AML) remain poorly understood. Multiple studies support that the bone marrow (BM) microenvironment has an important influence on leukemia

Externí odkaz: https://doaj.org/article/68fff1e18858473c8d6aae7d06ef387c

Aging of the microenvironment influences clonality in hematopoiesis

Autor: Katharina Senger, Anja Niebel, Karin Dörr, Virág Vas, Hartmut Geiger

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42080 (2012)

The mechanisms of the age-associated exponential increase in the incidence of leukemia are not known in detail. Leukemia as well as aging are initiated and regulated in multi-factorial fashion by cell-intrinsic and extrinsic factors. The role of agin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fa626a0efd0b80184acfaa17780a36
https://pubmed.ncbi.nlm.nih.gov/22879906

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

Autor: Barbara M. Bakker, Jildau Bouwman, Juha-Pekka Pitkänen, Ayca Cankorur, Nicola Zamboni, Lara Bogner, Betul Kirdar, Juan I. Castrillo, Ismo Mattila, Christopher T. Workman, Laura Salusjärvi, Alessandro Fazio, Matthias Reuss, Joseph J. Heijnen, Nicola Harrison, Karen van Eunen, Jens Nielsen, Johannes H. de Winde, Dina Petranovic, Jennifer C. Ewald, Martin Siemann-Herzberg, Jie Zhang, Stephen G. Oliver, Merja Penttilä, Joost van den Brink, Pramote Chumnanpuen, David James Sherman, Duygu Dikicioglu, Uwe Sauer, Hans V. Westerhoff, Femke I. C. Mensonides, Pascale Daran-Lapujade, Jack T. Pronk, Anja Niebel, André B. Canelas

Publikováno v: Nature Communications, 1
Nature Communications, 1:145. Nature Publishing Group
Nature Communications
Nature Communications, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩
Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkänen, J P, Van Den Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, Van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Penttilä, M, Pronk, J T, Reuss, M, Salusjärvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H, De Winde, J, Petranovic, D, Oliver, S G, Workman, C T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, no. 9, 145 . https://doi.org/10.1038/ncomms1150
Nature Communications, Nature Publishing Group, 2010, 1 (9), pp.145. ⟨10.1038/ncomms1150⟩
Nature Communications, 1. Nature Publishing Group
Canelas, A B, Harrison, N, Fazio, A, Zhang, J, Pitkanen, J-P, van der Brink, J, Bakker, B M, Bogner, L, Bouwman, J, Castrillo, J I, Cankorur, A, Chumnanpuen, P, Daran-Lapujade, P, Dikicioglu, D, van Eunen, K, Ewald, J C, Heijnen, J J, Kirdar, B, Mattila, I, Mensonides, F I C, Niebel, A, Pentilla, M, Pronk, J T, Reuss, M, Salusjarvi, L, Sauer, U, Sherman, D, Siemann-Herzberg, M, Westerhoff, H V, de Winde, J H, Petranovi, D, Oliver, S G, Workman, T, Zamboni, N & Nielsen, J 2010, ' Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains ', Nature Communications, vol. 1, 145 . https://doi.org/10.1038/ncomms1150

The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d45218838b5882bcd4b8382d3e90bac
http://resolver.tudelft.nl/uuid:797dd093-c0a9-492c-8967-3ff88657db98

Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

Autor: Klaus Mauch, Klaus Maier, Anja Niebel, Gabriele Vacun, Matthias Reuss, Ute Hofmann

Publikováno v: Biotechnology and bioengineering. 100(2)

An experimental set-up for acquiring metabolite and transient 13C-labeling data in mammalian cells is presented. An efficient sampling procedure was established for hepatic cells cultured in six-well plates as a monolayer attached to collagen, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710289183edd71b2c118c38f3cc73a12
https://pubmed.ncbi.nlm.nih.gov/18095337