CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells

Autor: Daniela Wesch, Matthias Peipp, Andreas Humpe, J.G.J. van de Winkel, P. W. Parren, Dieter Kabelitz, Anja Muskulus, Renate Burger, Christian Kellner, Sebastian Lutz, Martin Gramatzki, Hans-Heinrich Oberg

Publikováno v: Peipp, M, Wesch, D, Oberg, H H, Lutz, S, Muskulus, A, van de Winkel, J G J, Parren, P W H I, Burger, R, Humpe, A, Kabelitz, D, Gramatzki, M & Kellner, C 2017, ' CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells ', Scandinavian Journal of Immunology, vol. 86, no. 4, pp. 196-206 . https://doi.org/10.1111/sji.12581

Human γδ T cells are innate-like T cells which are able to kill a broad range of tumor cells and thus may have potential for cancer immunotherapy. The activating receptor natural killer group 2 member D (NKG2D) plays a key role in regulating immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446e5c0ed34b1f93fde1e38c1796209d
https://pubmed.ncbi.nlm.nih.gov/28708284

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC

Autor: Paul W. H. I. Parren, Michael Dechant, Thomas Valerius, Jan G. J. van de Winkel, Matthias Staudinger, Patrick Van Berkel, Dalia Akramiene, Christian Kellner, Anja Muskulus, Martin Gramatzki, Pia Glorius, Georg H. Fey, Matthias Peipp, Sahar Mohseni Nodehi, Roland Repp

Publikováno v: Journal of immunological methods. 373(1-2)

Protein- or glyco-engineering of antibody molecules can be used to enhance Fc-mediated effector functions. ScFv-Fc fusion proteins (scFv-Fc) represent interesting antibody derivatives due to their relatively simple design and increased tissue penetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db8fe91f82e806a6cffd9462c2d5843
https://pubmed.ncbi.nlm.nih.gov/21855548