Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Anja Lührmann"'
Autor:
Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter J. Oefner, Anja Lührmann, Katja Dettmer, Roland Lang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiel
Externí odkaz:
https://doaj.org/article/23f2879e75db4e8f8ffeb227a10843fd
Autor:
Alexander Biedermann, Maria Patra-Kneuer, Dimitrios Mougiakakos, Maike Büttner-Herold, Doris Mangelberger-Eberl, Johannes Berges, Christian Kellner, Sarah Altmeyer, Jörg Thomas Bittenbring, Christian Augsberger, Kristina Ilieva-Babinsky, Stefan Haskamp, Fabian Beier, Christopher Lischer, Julio Vera, Anja Lührmann, Simone Bertz, Simon Völkl, Benedikt Jacobs, Stefan Steidl, Andreas Mackensen, Heiko Bruns
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Macrophages are one of the key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD19 antibody tafasitamab, approved in combination with lenalidomide for the treatment of relapsed or refractory (r/r) diffuse larg
Externí odkaz:
https://doaj.org/article/83e0d53a47ba41ce83058f40a666be1f
Autor:
Benjamin U. Bauer, Michael R. Knittler, Jennifer Andrack, Christian Berens, Amely Campe, Bahne Christiansen, Akinyemi M. Fasemore, Silke F. Fischer, Martin Ganter, Sophia Körner, Gustavo R. Makert, Svea Matthiesen, Katja Mertens-Scholz, Sven Rinkel, Martin Runge, Jan Schulze-Luehrmann, Sebastian Ulbert, Fenja Winter, Dimitrios Frangoulidis, Anja Lührmann
Publikováno v:
International Journal of Medical Microbiology, Vol 313, Iss 6, Pp 151590- (2023)
The Q-GAPS (Q fever GermAn interdisciplinary Program for reSearch) consortium was launched in 2017 as a German consortium of more than 20 scientists with exceptional expertise, competence, and substantial knowledge in the field of the Q fever pathoge
Externí odkaz:
https://doaj.org/article/376d764835fa4a75a0ffa62e9fe08826
Autor:
Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler‐Tenorio, Jan Schulze‐Luehrmann, Michael Mauermeir, Kai‐Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens‐Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product
Externí odkaz:
https://doaj.org/article/1b69987f304e4114b08d5e4633d04bb6
Autor:
Anja Lührmann, Andrea Palmini, Justinus Hellmich, Vitaly Belik, Jürgen Zentek, Wilfried Vahjen
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290554 (2023)
Reducing antibiotic use is one of the biggest challenges in pig farming, as antibiotics have been used for years to control typical problems such as newborn or post-weaning diarrhea. The pressure a one health approach has created on animal production
Externí odkaz:
https://doaj.org/article/a9fd190171224a9a8d383ab3f424db78
Autor:
Michael Mauermeir, Martha Ölke, Inaya Hayek, Jan Schulze-Luehrmann, Katja Dettmer, Peter J. Oefner, Christian Berens, Christian Menge, Anja Lührmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCoxiella burnetii is a zoonotic pathogen, infecting humans, livestock, pets, birds and ticks. Domestic ruminants such as cattle, sheep, and goats are the main reservoir and major cause of human infection. Infected ruminants are usually asym
Externí odkaz:
https://doaj.org/article/2c135c8d26e84245b63690552ad21a9b
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
HIF1α is an important transcription factor regulating not only cellular responses to hypoxia, but also anti-infective defense responses. We recently showed that HIF1α hampers replication of the obligate intracellular pathogen Coxiella burnetii whic
Externí odkaz:
https://doaj.org/article/d6516c91f5d9483097ad2e1de0c5cdac
Autor:
Arne Cordsmeier, Sven Rinkel, Myriam Jeninga, Jan Schulze-Luehrmann, Martha Ölke, Benedikt Schmid, Daniele Hasler, Gunter Meister, Georg Häcker, Michaela Petter, Paul A. Beare, Anja Lührmann
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2 (2022)
Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized secretion systems to inject bacterial effector proteins into
Externí odkaz:
https://doaj.org/article/94ffbda6c9e34508bd66071b94b27c11
Autor:
Anja Lührmann, Ksenia Ovadenko, Justinus Hellmich, Christoph Sudendey, Vitaly Belik, Jürgen Zentek, Wilfried Vahjen
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256112 (2021)
Strategies to combat microbiota-associated health problems are of high interest in pig production. Successful intervention strategies with beneficial long-term effects are still missing. Most studies on pig microbiota have been conducted under standa
Externí odkaz:
https://doaj.org/article/30377313662a41dfa644971c17669ae0
Autor:
Julian Pechstein, Jan Schulze-Luehrmann, Stephanie Bisle, Franck Cantet, Paul A. Beare, Martha Ölke, Matteo Bonazzi, Christian Berens, Anja Lührmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Coxiella burnetii is an obligate intracellular pathogen and the causative agent of the zoonotic disease Q fever. Following uptake by alveolar macrophages, the pathogen replicates in an acidic phagolysosomal vacuole, the C. burnetii-containing vacuole
Externí odkaz:
https://doaj.org/article/4abaf91bfbe14e8f9d5564f29a367a12