Výsledky vyhledávání

Regulation of the Ca2+ Channel TRPV6 by the Kinases SGK1, PKB/Akt, and PIKfyve

Autor: Mentor Sopjani, Florian Lang, Anja Kunert, Michael Föller, Fabian Klaus, Kamil Czarkowski, Jörg Laufer

Publikováno v: Journal of Membrane Biology. 233:35-41

The serum- and glucocorticoid-inducible kinase SGK1 and the protein kinase PKB/Akt presumably phosphorylate and, by this means, activate the mammalian phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3), which has in turn been shown to regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2ac8c01d2be3e5dce54dfe463e26b8
https://doi.org/10.1007/s00232-009-9222-0

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Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans

Autor: Anja Kunert, Peter F. Zipfel, Raimund Eck, Andrea Hartmann, Sophia Poltermann, Monika von der Heide

Publikováno v: Journal of Biological Chemistry. 282:37537-37544

The human pathogenic yeast Candida albicans utilizes host complement regulators for immune evasion. Here we identify the first fungal protein that binds Factor H and FHL-1. By screening a protein array of 4088 proteins of Saccharomyces cerevisiae, ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd18f698644071bdc942207956a2cfe
https://doi.org/10.1074/jbc.m707280200

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Immune Evasion of the Human Pathogen Pseudomonas aeruginosa: Elongation Factor Tuf Is a Factor H and Plasminogen Binding Protein

Autor: Michael Huhn, Ralf Hoffmann, T. Sakari Jokiranta, Christin Gruszin, Jens Hellwage, Peter F. Zipfel, Harald Seeberger, Anja Kunert, Josephine Losse, Stefan Mikkat, Daniela Volke, Ute Moellmann, Kerstin Kaendler

Publikováno v: The Journal of Immunology. 179:2979-2988

Pseudomonas aeruginosa is an opportunistic human pathogen that can cause a wide range of clinical symptoms and infections that are frequent in immunocompromised patients. In this study, we show that P. aeruginosa evades human complement attack by bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a927f5f3612fa3904f248f84762d24b1
https://doi.org/10.4049/jimmunol.179.5.2979

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The Host Immune Regulator Factor H Interacts via Two Contact Sites with the PspC Protein of Streptococcus pneumoniae and Mediates Adhesion to Host Epithelial Cells

Autor: Anja Kunert, Steffi Haelbich, Vaibhav Agarwal, Peter F. Zipfel, Sven Hammerschmidt, Christine Skerka

Publikováno v: The Journal of Immunology. 178:5848-5858

Pneumococcal surface protein C (PspC) of Streptococcus pneumoniae is a key virulence factor that mediates adhesion to host cells and immune evasion of the host complement. PspC binds the host immune and complement regulator factor H, which is compose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76de21931b70613c7da961c0bccd4f01
https://doi.org/10.4049/jimmunol.178.9.5848

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Autor: Albert Härtl, Florian Eberle, Harald Seeberger, Mihály Józsi, T. Sakari Jokiranta, Heiko Richter, Jens Hellwage, Tanja Babuke, Peter F. Zipfel, Anja Kunert

Publikováno v: Immunogenetics. 58:883-893

Complement factor H-related (FHR) proteins display structural and functional similarities to each other and to the complement regulator factor H (FH). FHRs have been identified in various species, including human, rat, and the fish barred sand bass.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd274567a5b2db5aacf517e896c2b6fa
https://doi.org/10.1007/s00251-006-0153-y

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Factor H and Atypical Hemolytic Uremic Syndrome

Autor: Stefan Heinen, Stephen J. Perkins, Christoph Licht, Anja Kunert, Mihály Józsi, Heiko Richter, Clemens W. Ostrowicz, Andrea Hartmann, Christine Skerka, Rebecca E. Saunders, Peter F. Zipfel, Steffi Hälbich

Publikováno v: Journal of the American Society of Nephrology. 17:170-177

Atypical hemolytic uremic syndrome is a disease that is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Mutations in the complement regulator factor H are associated with the inherited form of the diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ec14f076ecf3bc6ee2250ee0f12d42
https://doi.org/10.1681/asn.2005080868

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Repression by Fur is not the main mechanism controlling the iron-inducibleisiABoperon in the cyanobacteriumSynechocystissp. PCC 6803

Autor: Norbert Erdmann, Anja Kunert, Josef Vinnemeier, Martin Hagemann

Publikováno v: FEMS Microbiology Letters. 227:255-262

The iron deficiency-dependent regulation of isiAB transcription in Synechocystis sp. PCC 6803 was analyzed by fusion of modified isiAB promoter fragments to gfp and in vivo quantification of Gfp fluorescence. For the putative Fur box only a slight re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a34de160dc1ccc0c5c1cf3c6b2d20d2
https://doi.org/10.1016/s0378-1097(03)00689-x

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Novel ubiquitin-derived high affinity binding proteins with tumor targeting properties

Autor: Jörg Nerkamp, Christian M. Lange, Arnd Steuernagel, Ilka Hänssgen, Anja Kunert, Maren Meysing, Ulrike Fiedler, Chris Rundfeldt, Markus Fiedler, Eva Bosse-Doenecke, Una Rauchhaus, Thomas Göttler, Susan Lorey, Ulrich Haupts, Erik Fiedler, Manja Gloser

Publikováno v: The Journal of Biological Chemistry

Background: Targeting molecules to tumor cells is a promising mode of action for cancer therapy. Results: Ubiquitin-based high affinity, specific, and stable binding molecules for extradomain B are accumulated in the tumor. Conclusion: Ubiquitin may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee2b3b25ace920cfb063b6ef304588
https://pubmed.ncbi.nlm.nih.gov/24474690

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Detection of the isiA Gene across Cyanobacterial Strains: Potential for Probing Iron Deficiency

Autor: B. Gemmer, Anja Kunert, I. Lindner, Maike Lorenz, Ulrike Geiß, Martin Hagemann, Arne Schoor, Josef Vinnemeier

Publikováno v: Applied and Environmental Microbiology. 67:5247-5253

Iron as an important micronutrient of phytoplankton had been neglected for a long period before Martin and coworkers (28–30) revived its consideration in their approach to defining the basic pattern of plankton productivity in the open oceans. Subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230df9d4b21bd47114f170455fe92f8e
https://doi.org/10.1128/aem.67.11.5247-5253.2001

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Transcriptional analysis of theisiABoperon in salt-stressed cells of the cyanobacteriumSynechocystissp. PCC 6803

Autor: Josef Vinnemeier, Martin Hagemann, Anja Kunert

Publikováno v: FEMS Microbiology Letters. 169:323-330

Expression of the isiA and isiB genes was analysed in the cyanobacterium Synechocystis sp. PCC 6803 grown in high salt or in iron-deficient medium. The detection of a 2.3-knt transcript in Northern blot experiments indicated cotranscription of isiAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72d90194b8884c5a76c3ddd411ceccf
https://doi.org/10.1111/j.1574-6968.1998.tb13336.x

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