Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anja Kathrin, Wege"'
Autor:
Simona Mareike Lüttgenau, Christin Emming, Thomas Wagner, Julia Harms, Justine Guske, Katrin Weber, Ute Neugebauer, Rita Schröter, Olga Panichkina, Zoltán Pethő, Florian Weber, Albrecht Schwab, Anja Kathrin Wege, Pavel Nedvetsky, Michael P. Krahn
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Abstract Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals
Externí odkaz:
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
Autor:
Anja Kathrin Wege, Nicole Kirchhammer, Linda Veronique Kazandjian, Sandra Prassl, Michael Brandt, Gerhard Piendl, Olaf Ortmann, Stephan Fischer, Gero Brockhoff
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Antibody based cancer therapies have achieved convincing success rates combining enhanced tumor specificity and reduced side effects in patients. Trastuzumab that targets the human epidermal growth factor related receptor 2 (HER2)
Externí odkaz:
https://doaj.org/article/cd7cf64a32de421eaa9056447233790c
Autor:
Anja Kathrin Wege, Dominik Chittka, Stefan Buchholz, Monika Klinkhammer-Schalke, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann, Gero Brockhoff
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth factor receptor-related re
Externí odkaz:
https://doaj.org/article/0b0307b1ee124192bee8988bedc1b8d3
Autor:
Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl‐Dimiter Bissig, Brian Soper, Terrence Meeham, Li‐Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb‐Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
Abstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a
Externí odkaz:
https://doaj.org/article/0b7a5df243a34bd59c1903d19ca29593
Autor:
Nicole Zimara, Menberework Chanyalew, Abraham Aseffa, Ger van Zandbergen, Bernd Lepenies, Maximilian Schmid, Richard Weiss, Anne Rascle, Anja Kathrin Wege, Jonathan Jantsch, Valentin Schatz, Gordon D. Brown, Uwe Ritter
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibili
Externí odkaz:
https://doaj.org/article/97056ff6029345348f2eb69f10de9238
Autor:
Anja Kathrin Wege, Eva‐Maria Rom‐Jurek, Paul Jank, Carsten Denkert, Peter Ugocsai, Christine Solbach, Jens‐Uwe Blohmer, Bruno Sinn, Marion Mackelenbergh, Volker Möbus, Andreas Trumpp, Elisabetta Marangoni, Nicole Pfarr, Christoph Irlbeck, Jens Warfsmann, Bernhard Polzer, Florian Weber, Olaf Ortmann, Sibylle Loibl, Valentina Vladimirova, Gero Brockhoff
Publikováno v:
International journal of cancerREFERENCES. 150(8)
Estrogen receptor-positive breast cancer is a highly prevalent but heterogeneous disease among women. Advanced molecular stratification is required to enable individually most efficient treatments based on relevant prognostic and predictive biomarker
Autor:
Anja Kathrin Wege, Valentina Vladimirova, Christine Solbach, Eva-Maria Rom-Jurek, Jens-Uwe Blohmer, Paul Jank, Bruno Sinn, Andreas Trumpp, Elisabetta Marangoni, Knut Engels, Wilko Weichert, Nicole Pfarr, Christoph Irlbeck, Bernhard Polzer, Olaf Ortmann, Marion van Mackelenbergh, Carsten Denkert, Sibylle Loibl, Gero Brockhoff
Publikováno v:
Cancer Research. 82:PD9-07
Background: Luminal, i.e., estrogen receptor (ER)-positive breast cancer (BC) is a heterogeneous disease in terms of tumor progression, therapy response, and relapse. Additional biomarkers with a prognostic and predictive impact would facilitate adva
Autor:
Michael A. Brehm, Carol J. Bult, Johannes Sam, Florian Klein, Silvia Guionaud, Karl-Dimiter Bissig, James P. Di Santo, Anja Kathrin Wege, Terrence Meeham, Dominique Bonnet, Scott G. Kitchen, Livio Trusolino, Kourosh Saeb-Parsy, Christian Münz, Brian Soper, Kristina E. Howard, Amar Deep Sharma, Renata Stripecke, Estefanía Rodríguez, Leonard D. Shultz, Li-Chin Yao, Andreas Trumpp, Jan Jacob Schuringa
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant
Publikováno v:
Frontiers in Microbiology, Vol 3 (2012)
Since the first description of dendritic cells (DCs) by Ralph Marvin Steinman and Zanvil Alexander Cohn in 1973, the myeloid lineage of leukocytes was investigated intensively. Nowadays it is obvious that myeloid cells, especially DCs, are crucial fo
Externí odkaz:
https://doaj.org/article/73a886a7f83b437ea2e08ca4b0afe1ee
Autor:
Anja Kathrin Wege, Christian Florian, Wolfgang Ernst, Nicole Zimara, Ulrike Schleicher, Frank Hanses, Maximilian Schmid, Uwe Ritter
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1741 (2012)
BACKGROUND: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show
Externí odkaz:
https://doaj.org/article/69d6847b385e497a9113653c81b31bac