Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anja J. Stauber"'
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:174-184
A humanized monoclonal antibody targeting transforming growth factor β1 (TGF-β1 mab) has been used in development for the treatment of chronic kidney disease. Embryo-fetal development studies were conducted in rats and rabbits using 30 and 25 anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a7a49c12d45c72f2cc250aa9a26585
https://doi.org/10.1002/bdrb.21182
https://doi.org/10.1002/bdrb.21182
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 107(4-5)
A humanized monoclonal antibody targeting transforming growth factor β1 (TGF-β1 mab) has been used in development for the treatment of chronic kidney disease. Embryo-fetal development studies were conducted in rats and rabbits using 30 and 25 anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9370f3faf035aac0f5f014294de2e3a
https://pubmed.ncbi.nlm.nih.gov/27519584
https://pubmed.ncbi.nlm.nih.gov/27519584
Activation of Peroxisome Proliferator–Activated Receptor Alpha Enhances Apoptosis in the Mouse Liver
Autor:
J. Christopher Corton, Shen Xiao, Anja J. Stauber, Kenneth A. Voss, Rainer Bahnemann, Steven P. Anderson, Cynthia Swanson
Publikováno v:
Toxicological Sciences. 92:368-377
Chronic exposure to peroxisome proliferators (PPs) leads to increased incidence of liver tumors in rodents. Liver tumor induction is thought to require increased hepatocyte proliferation and suppression of apoptosis. Transcript profiling showed incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06144dac0b5a35766596a63d7c5128f
https://doi.org/10.1093/toxsci/kfl002
https://doi.org/10.1093/toxsci/kfl002
Autor:
Rebecca A. Staben, Cynthia Swanson, J. Christopher Corton, Michael P. Waalkes, Ashley Laughter, Jie Liu, Anja J. Stauber, Kenneth A. Voss, Jaqueline C. Coley, John J. Kopchick, Holly M. Brown-Borg
Publikováno v:
Molecular Pharmacology. 67:681-694
Defects in growth hormone secretion or signaling in mice are associated with decreased body weights (dwarfism), increased longevity, increased resistance to stress, and decreases in factors that contribute to cardiovascular disease and cancer. Peroxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a775d057390f62b25fda4be68199069e
https://doi.org/10.1124/mol.104.007278
https://doi.org/10.1124/mol.104.007278
Publikováno v:
Journal of Clinical Toxicology.
Objective: The transforming growth factor β (TGF-β) pathway regulates diverse cellular functions and plays a prominent role in diseases such as cancer, autoimmune disorders and cardiovascular disease. LY2157299 monohydrate (LY2157299) is a potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d71f13c8c57564bc54c7d61f2b38462d
https://doi.org/10.4172/2161-0495.196
https://doi.org/10.4172/2161-0495.196
Publikováno v:
Journal of Applied Toxicology. 21:81-89
Haloacetates are produced in the chlorination of drinking water in the range 10--100 microg l(-1). As bromide concentrations increase, brominated haloacetates such as bromodichloroacetate (BDCA), bromochloroacetate (BCA) and dibromoacetate (DBA) appe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbd4822767b5f66976f73c4fc9e0679
https://doi.org/10.1002/jat.717
https://doi.org/10.1002/jat.717
Publikováno v:
Toxicology and Applied Pharmacology. 150:287-294
Dichloroacetate (DCA) and trichloroacetate (TCA) are hepatocarcinogenic by-products of water chlorination and metabolites of several industrial solvents. To determine whether DCA and TCA promote the clonal expansion of anchorage-independent liver cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c11787b17ac05164a90be578f3043b
https://doi.org/10.1006/taap.1998.8417
https://doi.org/10.1006/taap.1998.8417
Autor:
Anja J. Stauber, Rita S. Cheng, Lisa C. Stillwell, Melissa K. Lingohr, Brian D. Thrall, Gayle A. Orner, Richard J. Bull, Lyle B. Sasser
Publikováno v:
Toxicology and applied pharmacology. 182(1)
Determining the key events in the induction of liver cancer in mice by trichloroethylene (TRI) is important in the determination of how risks from this chemical should be treated at low doses. At least two metabolites can contribute to liver cancer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88793ae1005da78feeee6dafa0c23cf4
https://pubmed.ncbi.nlm.nih.gov/12127263
https://pubmed.ncbi.nlm.nih.gov/12127263
Autor:
Anja J. Stauber, J. Christopher Corton
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 58(2)
The article highlighted in this issue is Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells by Michael E. Burczynski, Michael McMillian, Joe Ciervo, Li Li, James B. Parker, Robert Y. Dunn II, Sam Hicken, Spencer Farr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7025bc8b29c8ae2b39e6a34b2bb7c23d
https://pubmed.ncbi.nlm.nih.gov/11099651
https://pubmed.ncbi.nlm.nih.gov/11099651
Publikováno v:
Annual review of pharmacology and toxicology. 40
Peroxisome proliferators (PPs) are a large class of structurally dissimilar chemicals that have diverse effects in rodents and humans. Most, if not all, of the diverse effects of PPs are mediated by three members of the nuclear receptor superfamily c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222a8d14faba5e9b7eeb6d279fac9e68
https://pubmed.ncbi.nlm.nih.gov/10836145
https://pubmed.ncbi.nlm.nih.gov/10836145