Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Anja Hofmann"'
Autor:
Heike Brendel, Jennifer Mittag, Anja Hofmann, Helene Hempel, Sindy Giebe, Patrick Diaba-Nuhoho, Steffen Wolk, Christian Reeps, Henning Morawietz, Coy Brunssen
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1178 (2024)
Aim: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through H2O2 production. Therefore, we aimed to elucidate NOX4′s significance in endothelial fu
Externí odkaz:
https://doaj.org/article/665eb58dafb74c9d82a5012dd29931e5
Autor:
Anna-Leonie Menges, Maja Nackenhorst, Johannes R. Müller, Marie-Luise Engl, Renate Hegenloh, Jaroslav Pelisek, Ellen Geibelt, Anja Hofmann, Christian Reeps, Gabor Biro, Hans-Henning Eckstein, Alexander Zimmermann, Derek Magee, Martin Falk, Nadja Sachs, Albert Busch
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Abdominal aortic aneurysm (AAA) is a pathologic enlargement of the infrarenal aorta with an associated risk of rupture. However, the responsible mechanisms are only partially understood. Based on murine and human samples, a heterogeneous dis
Externí odkaz:
https://doaj.org/article/67455cab17324b0c9f92219a7b03342b
Autor:
Michael Adu-Gyamfi, Claudia Goettsch, Julian Kamhieh-Milz, Lei Chen, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor Müller, Thomas Walther, Muhammad Imtiaz Ashraf, Henning Morawietz, Janusz Witowski, Rusan Catar
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 500 (2024)
Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechani
Externí odkaz:
https://doaj.org/article/93e54855a4cf439a8fdd4396e9578845
Autor:
Anja Hofmann, Yazan Khorzom, Anna Klimova, Steffen Wolk, Albert Busch, Pamela Sabarstinski, Margarete Müglich, Dmitry Egorov, Irakli Kopaliani, David M. Poitz, Marvin Kapalla, Bianca Hamann, Frieda Frank, Christian Jänichen, Coy Brunssen, Henning Morawietz, Christian Reeps
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)
Background Indication for prophylactic surgical abdominal aortic aneurysm (AAA) repair depends on the maximal aortic diameter. The lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) is the major receptor for uptake of oxidized lo
Externí odkaz:
https://doaj.org/article/2964b3e96fb54f1fab2e75398456715b
Autor:
Anna-Leonie Menges, Maja Nackenhorst, Johannes R. Müller, Marie-Luise Engl, Renate Hegenloh, Jaroslav Pelisek, Ellen Geibelt, Anja Hofmann, Christian Reeps, Gabor Biro, Hans-Henning Eckstein, Alexander Zimmermann, Derek Magee, Martin Falk, Nadja Sachs, Albert Busch
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c4688c212c9646ffabab9b39b4dde9a5
Autor:
Roman N. Rodionov, Natalia Jarzebska, Dmitrii Burdin, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Anne Kolouschek, Nada Cordasic, Johannes Jacobi, Elena Rubets, Henning Morawietz, John F. O’Sullivan, Alexander G. Markov, Stefan R. Bornstein, Karl Hilgers, Renke Maas, Christian Pfluecke, YingJie Chen, Stefanie M. Bode-Böger, Christian P. M. Hugo, Bernd Hohenstein, Norbert Weiss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) are associated with an increased risk of mortality and adverse cardiovascular outcomes. ADMA can be metabolized by dimethylarginine dimethylaminohydrolases (DDAHs) and by a
Externí odkaz:
https://doaj.org/article/674f7781bc76496db8e890262bf3eaf5
Autor:
Anja Hofmann, Frieda Frank, Steffen Wolk, Albert Busch, Anna Klimova, Pamela Sabarstinski, Michael Gerlach, Dmitry Egorov, Irakli Kopaliani, Sönke Weinert, Bianca Hamann, David M. Poitz, Coy Brunssen, Henning Morawietz, Katrin Schröder, Christian Reeps
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102473- (2022)
Carotid artery stenosis (CAS) develops from atherosclerotic lesions and plaques. Plaque rupture or stenosis may result in occlusion of the carotid artery. Accordingly, the asymptomatic disease becomes symptomatic, characterized by ischemic stroke or
Externí odkaz:
https://doaj.org/article/84987cca1a354f7a9260c394bd8eca21
Autor:
Bianca Hamann, Anna Klimova, Felicia Klotz, Frieda Frank, Christian Jänichen, Marvin Kapalla, Pamela Sabarstinski, Steffen Wolk, Henning Morawietz, David M. Poitz, Anja Hofmann, Christian Reeps
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 947 (2023)
Red blood cells are found within the abdominal aortic aneurysm (AAA), in the intraluminal thrombus (ILT), and in neovessels. Hemolysis promotes aortic degeneration, e.g., by heme-induced reactive oxygen species formation. To reduce its toxicity, hemo
Externí odkaz:
https://doaj.org/article/316b842c78dc4e18a9a634cc2406bc1f
Autor:
Sindy Giebe, Anja Hofmann, Melanie Brux, Frazer Lowe, Damien Breheny, Henning Morawietz, Coy Brunssen
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102150- (2021)
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used. However, little is known about their potenti
Externí odkaz:
https://doaj.org/article/28eb7f53b2914088807198dc2bea7fac
Autor:
Anja Hofmann, Bianca Hamann, Anna Klimova, Margarete Müglich, Steffen Wolk, Albert Busch, Frieda Frank, Pamela Sabarstinski, Marvin Kapalla, Josef Albin Nees, Coy Brunssen, David M. Poitz, Henning Morawietz, Christian Reeps
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1753 (2022)
Background: Treatment of cardiovascular risk factors slows the progression of small abdominal aortic aneurysms (AAA). Heme oxygenase-1 (HO-1) is a stress- and hemin-induced enzyme providing cytoprotection against oxidative stress when overexpressed.
Externí odkaz:
https://doaj.org/article/0bf1026255a24febb22a758e9ac32bf3