Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anja Henningsson"'
Autor:
Jeffrey Wald, Anja Henningsson, Eva Hanze, Ethan Hoffmann, Haihong Li, Helen Colquhoun, Kristina M. Deligiannidis
Publikováno v:
Clinical pharmacokinetics. 61(9)
Women with postpartum depression (PPD) may expose their infants to antidepressants via breast milk. Brexanolone is the only FDA-approved antidepressant specifically indicated for the treatment of PPD. This open-label, phase Ib study of healthy lactat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a225503eb750dfcaff724f4c06dad4
https://pubmed.ncbi.nlm.nih.gov/35869362
https://pubmed.ncbi.nlm.nih.gov/35869362
Publikováno v:
British Journal of Clinical Pharmacology. 83:1723-1733
Aims A population pharmacokinetic (PK) model was developed for cediranib to simulate cediranib exposure for different doses, including comedication with strong uridine glucuronosyl transferase/P-glycoprotein inducers such as rifampicin, in cancer pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ad2a111fd774b72a5fcfff9d0965f0
https://doi.org/10.1111/bcp.13266
https://doi.org/10.1111/bcp.13266
Autor:
Steven M. Toler, Hongmei Xu, Nidal Al-Huniti, Jessica S. Beaver, Raj Tummala, Sofie Alverlind, Anja Henningsson
Publikováno v:
The Journal of Clinical Pharmacology. 54:707-718
TC-5214 (dexmecamylamine) is a nicotinic channel modulator that has previously been evaluated for treatment of major depression disorder (MDD) and is currently being evaluated by Targacept as a treatment for overactive bladder. A comprehensive popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b6eac57fe33e1c9bb0feb224f86a3b
https://doi.org/10.1002/jcph.264
https://doi.org/10.1002/jcph.264
Publikováno v:
British journal of clinical pharmacology. 83(8)
A population pharmacokinetic (PK) model was developed for cediranib to simulate cediranib exposure for different doses, including comedication with strong uridine glucuronosyl transferase/P-glycoprotein inducers such as rifampicin, in cancer patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba6b25a9a96dfb7a1c5945f5a68f8e97
https://pubmed.ncbi.nlm.nih.gov/28213941
https://pubmed.ncbi.nlm.nih.gov/28213941
Publikováno v:
Clinical Cancer Research. 12:5481-5490
Purpose: Cancer chemotherapy, although based on body surface area, often causes unpredictable myelosuppression, especially severe neutropenia. The aim of this study was to evaluate qualitatively and quantitatively the influence of patient-specific ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc684e26388f30663f0adde29a8cf8ff
https://doi.org/10.1158/1078-0432.ccr-06-0815
https://doi.org/10.1158/1078-0432.ccr-06-0815
Publikováno v:
Journal of Clinical Oncology. 20:4713-4721
PURPOSE: To develop a semimechanistic pharmacokinetic-pharmacodynamic model describing chemotherapy-induced myelosuppression through drug-specific parameters and system-related parameters, which are common to all drugs. PATIENTS AND METHODS: Patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92c8f0b3cc6a29d0cf54b70af79b2f
https://doi.org/10.1200/jco.2002.02.140
https://doi.org/10.1200/jco.2002.02.140
Autor:
Hongmei, Xu, Anja, Henningsson, Sofie, Alverlind, Raj, Tummala, Steven, Toler, Jessica S, Beaver, Nidal, Al-Huniti
Publikováno v:
Journal of clinical pharmacology. 54(6)
TC-5214 (dexmecamylamine) is a nicotinic channel modulator that has previously been evaluated for treatment of major depression disorder (MDD) and is currently being evaluated by Targacept as a treatment for overactive bladder. A comprehensive popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efd6b09424489977e947937aeae054f1
https://pubmed.ncbi.nlm.nih.gov/24408516
https://pubmed.ncbi.nlm.nih.gov/24408516
Publikováno v:
Clinical pharmacokinetics. 51(2)
Modelling and simulation (M&S) of clinical data, e.g. pharmacokinetic, pharmacodynamic and clinical endpoints, is a useful approach for more efficient interpretation of collected data and for extrapolation of knowledge to the entire target population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f084373991f5e2f8196c155900c19d5
https://pubmed.ncbi.nlm.nih.gov/22257148
https://pubmed.ncbi.nlm.nih.gov/22257148
Publikováno v:
Clinical Trial Simulations ISBN: 9781441974143
Modeling and simulation of pharmacokinetic and pharmacodynamic/response data has been increasingly advocated during drug development, to allow more efficient utilization of collected clinical data and to support informed decision making, e.g., regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a04481c5fa27cb7e9c744c67a7a395
https://doi.org/10.1007/978-1-4419-7415-0_2
https://doi.org/10.1007/978-1-4419-7415-0_2
Autor:
Adam A. Garsa, Mats O. Karlsson, Alberta Locatelli, Lucia Viganò, Walter J. Loos, Alex Sparreboom, Sharon Marsh, Stephan Mielke, Howard L. McLeod, Jaap Verweij, Klaus Mross, Anja Henningsson
Publikováno v:
Clinical Cancer Research, 11(22), 8097-8104. American Association for Cancer Research Inc.
Purpose: To retrospectively evaluate the effects of six known allelic variants in the CYP2C8, CYP3A4, CYP3A5, and ABCB1 genes on the pharmacokinetics of the anticancer agent paclitaxel (Taxol). Experimental Design: A cohort of 97 Caucasian patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910f9f71913b00b65eacc5bfa3c2b2cb
https://pubmed.ncbi.nlm.nih.gov/16299241
https://pubmed.ncbi.nlm.nih.gov/16299241