Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin

Autor: René Roy, Anja Glinschert, Qingan Wang, Alex Papadopoulos, Gérard Vergoten, Eva-Maria Krammer, Leila Mousavifar, Julie Bouckaert, Emmanuel Maes, Stefan Oscarson, Nao Yamakawa, Mohamed Touaibia, Tze Chieh Shiao, Marc F. Lensink

Publikováno v: Molecules
Molecules, 2017, 22 (7), pp.1101. ⟨10.3390/molecules22071101⟩
Molecules, MDPI, 2017, 22 (7), pp.1101. ⟨10.3390/molecules22071101⟩
Molecules, Vol 22, Iss 7, p 1101 (2017)
Molecules; Volume 22; Issue 7; Pages: 1101
Molecules, 22 (7
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Antagonists of the Escherichia coli type-1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against acute and recurrent bacterial infections. In this study α-d-mannopyranosides O- or C-linked w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af78d9aab2a506ec56fcfc490ca4e24
https://hal.science/hal-02389369

Synthesis of four (4'-, 2'-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-α-D-ManpOMe recognized by Calreticulin/Calnexin

Autor: Anja Glinschert, Stefan Oscarson

Publikováno v: Carbohydrate research. 414

Routes for efficient synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-α-D-ManpOMe have been developed. For the introduction of the 2'- and 2"-deoxy motifs the most efficient way

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21099b4f552e7d6e3c53e791630acb0
https://pubmed.ncbi.nlm.nih.gov/26257376